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Biomedical subjects

J B Murray

Publications and source records attributed to J B Murray.

At least 55 records · Page 3Linked to original sources

Difficulty as a determinant of cardiovascular response: moderating effect of instrumentality in an alleviation paradigm.

Female subjects performed 40 trials of an easy or difficult digit-recognition task while being exposed to intermittent presentations of a noxious noise. Half (high instrumentality) were told that, if they performed well, there was a high chance that they would work without noise in a subsequent trial period. The rest (low instrumentality) were told that, if they performed well, there was a low chance that they would work without noise in the subsequent trial period. Thus, a good performance insured either a high or low probability of alleviating the aversive stimulus. Results indicated that systolic responsiveness was proportional to task demand when the instrumentality of alleviative behavior was high, but low under both task conditions when the instrumentality of alleviative behavior was low. Reaction time and performance data were generally consistent with the view that these effects were due to group differences in task engagement, or 'active coping'. The main findings conceptually replicate and extend results from two previous studies that crossed difficulty and instrumentality manipulations. They also call further into question familiar theoretical conceptions that intimate direct effects of incentive value and perceived control on cardiovascular reactivity.

Adaptation, Psychological↗

Review of research on pathological gambling.

The literature including a number of review articles was examined for answers to the questions, have distinctive personality test profiles of pathological gamblers been identified, do pathological gamblers have control over their behavior, have studies of alcoholism and addiction increased understanding of compulsive gambling, and has psychotherapy or Gamblers Anonymous been successful for them? Much more information is needed to build on what research on these questions has yielded.

Gambling↗

Recombinant interleukin-2 treatment in patients with metastatic colorectal cancer: effect on natural cytotoxicity.

Natural cytotoxicity (natural killer, NK, and lymphokine-activated killer, LAK, activity) was documented in 12 patients with metastatic colorectal cancer, both before and after a 5-day course of continuous therapy with intravenous recombinant interleukin-2 (rIL-2). Treatment induced a substantial increase in circulating CD56+ lymphocytes (pretreatment: 12.1 +/- 6.9%, mean +/- SD; posttreatment: 39.2 +/- 6.9%. Maximal NK cell activity was induced by treatment with rIL-2 but only suboptimal augmentation of LAK cell cytotoxicity was obtained. This study indicates that although continuous infusion of rIL-2 does have a significant effect on natural cytotoxicity, this is suboptimal and further studies are necessary to define the most efficacious immunity-enhancing regimens of therapy, thereby hopefully improving clinical outcome of rIL-2 treatment.

Antineoplastic Combined Chemotherapy Protocols↗

Hyperdense renal cyst due to prolonged retention of iodinated contrast material: case report.

A case of a hyperdense renal cortical cyst resulting from cyst puncture and opacification 28 months previously is reported. Prolonged retention of water-soluble iodinated contrast material is an unusual cause of a hyperdense renal cyst, which has not previously been described. The findings on serial computed tomography (CT) and chemical analysis are presented and discussed.

Adult↗

Kleptomania: a review of the research.

Research on kleptomania is limited. Earlier views and recent reports of treatment are reviewed in this article. More study is needed to delineate this impulse-control disorder.

Child of Impaired Parents↗

Posttraumatic stress disorder: a review.

In this article, I have reviewed posttraumatic stress disorder with Vietnam veterans, soldiers in other wars, and in victims of natural and civilian disasters. A discussion of measurement and therapy approaches is included.

Combat Disorders↗

Psychophysiological aspects of nightmares, night terrors, and sleepwalking.

Monitoring sleep through electroencephalography and electroculography has identified the different sleep stages in which nightmares, night terrors, and sleepwalking occur. Questionnaire surveys have supplemented the findings of case studies of these sleep disorders. Neurotransmitters operative during these sleep disorders have enlarged the knowledge of the psychophysiological dimensions especially of nightmares.

Arousal↗

Psychoendocrinological aspects of affective disorders.

Psychoendocrinological studies have opened a new approach to understanding affective disorders. In this study, the links of affective illnesses to changes in endocrine secretions--particularly adrenal, gonadal, growth, pineal, thyroidal, and prolactin--were reviewed with the object of adding to the number of depressed whose symptoms can be relieved.

Depressive Disorder↗

Nicotine as a psychoactive drug.

Nicotine is a paradoxical drug in that it both stimulates and depresses functions. It affects the central nervous system, the peripheral nervous system, the cardiovascular, the skeletal, and the gastrointestinal systems. Its psychoactive effects and drug dependency potential as well as some therapeutic approaches to smoking cessation have been reviewed here. More research information is needed for professionals working with those who want to quit smoking.

Animals↗

New applications of lithium therapy.

Several placebo-controlled double-blind studies have indicated that lithium sometimes augments antidepressants, converting nonresponding patients to responders. Lithium therapy has also benefitted some schizoaffective patients and some alcoholics. Side effects are minimal. Mechanisms involved in lithium's effectiveness have not yet been discovered.

Alcoholism↗

Diazepam (Valium): its dependency liability.

Reports of the withdrawal syndrome following discontinuation of diazepam and drug dependence fears have contributed to diazepam's displacement as the most popular anxiolytic agent. Reports of the withdrawal syndrome, the factors involved in withdrawal, and the remedies proposed for diazepam withdrawal symptoms are reviewed.

Arousal↗

Grouping students for instruction: effects of learning style on achievement and attitudes.

The present study examined the effects of matching and mismatching American middle-school students with a preference for learning alone or learning with peers with selected instructional treatments in order to determine the impact upon their attitudes and achievement in social studies. Analysis revealed that the learning-alone preference performed significantly better in the learning-alone condition and that the learning-with-peers preference performed significantly better in the learning-with-peers condition. However, no-preference students also performed significantly better in the learning-alone condition than with peers. In addition, data revealed that the learning-alone and the learning-with-peers students had significantly more positive attitudes when matched with their preferred learning style; the nopreference students had more positive attitudes in the learning-alone condition.

Achievement↗

Neuroleptic-resistant schizophrenics.

According to Crow's postulated positive-negative distinction, negative symptoms of schizophrenia are less responsive to neuroleptic drugs. Not all research evidence supports that expectation, however, so that neuroleptics need not be withheld from any schizophrenic patients. Other aspects of Crow's hypothesized distinction have indicated possible promising results, but more research is required.

Antipsychotic Agents↗