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Biomedical subjects

J Arlet

Publications and source records attributed to J Arlet.

At least 109 records · Page 6Linked to original sources
PubMed1978

[Marrow scintigraphy in Paget's disease of bone (author's transl)].

Marrow scintigraphy using 99mTc colloids was performed in 20 patients with Paget's disease of bone and compared with skeletal scanning in each of them. As long as the regions explored were haematopoietically active, despite the advanced age of the patients, there was decreased marrow uptake in regions of increased uptake on the skeletal scan. Whilst increased uptake of pyrophosphate reflects bone hyperosteogenesis, decreased uptake of colloids reflects marrow fibrosis, and early histological sign of the disease. This scanning technique could be a new criterion in the surveillance of the therapeutic effectiveness of calcitonins or of diphosphonates.

Aged↗
PubMed1978

[Paget's disease, ankylosing vertebral hyperostosis and hyperostosis frontalis interna].

Ankylosing vertebral hyperostosis and internal frontal hyperostosis have a frequency of 5% and 8% respectively. In Paget's disease, these two disorders are found with a frequency of 40% and 19.1% respectively. This frequency is not due to chance. There exists a link between the 3 diseases. Ankylosing vertebral hyperostosis is thusa new pathological association in Paget's disease. It is even the most frequent of these associations. It seems Paget's disease induces hyperostosis and not the contrary. The authors suggest the theory that cortical and periostal hypervascularisation in pagetoid bone favour the development of these hyperostoses.

Aged↗
PubMed1978

[The hip in vertebral hyperostosis].

The study of two series of cases affected by vertebral hyperostosis allows the authors to underline the frequency with which the hip joint is affected and to describe the destructive forms seen in hyperostosis of the hip. In a first series of 101 cases the authors picked up 145 pathological hips which were probably or surely associated with hyperostosis. These hip disorders presented in three types: Type I (already described by J. Forestier et al.) with peri-articular proliferation and radiological integrity of the joint space; Type II with hyperostotic proliferation and narrowing of the joint space; Type III with epiphysial destruction. The study of a second series "of the development of 58 cases of hyperostotic hip disease" followed for 2-16 years raises the consideration that these three types are in fact three stages in the evolution of the condition.

Hip↗
PubMed1978

[Dorsal medullary compression in vertebral hyperostosis].

The authors present two observations of dorsal medullary compression by intraspinal benign osseous proliferations developing in subjects who present with anterior vertebral hyperostosis. In the second observation operative intervention confirmed the site and nature of the lesion. The authors have researched the same radiological findings in other cases of vertebral hyperostosis. They describe the lesions which are of considerable practical importance as they are able to injure the spinal cord and the nerve roots, resulting in a hyperostotic dorsal myelopathy. All unexplained paraplegias should be investigated for such lesions by meticulous tomographic studies.

Adult↗
PubMed1978

[Bone scintigraphy in Paget's disease].

Sixty patients with Paget's disease underwent bone scintigraphy and a radiological and biological exam. The use of scintigraphy in this disease is of double importance: it allows the spread of the disease to be diagnosed without doing X-rays of the entire skeleton. In twenty per cent of cases this disease cannot be located using X-rays and is detected by scintigraphy. It also supplies an additional objective criteria for judging the development of this disease, especially under treatment. The authors study the different hypotheses concerning the fixation to the bone of the isotope tracer in the Paget zone.

Aged↗
PubMed1978

[Coxarthroses due to ischemia. Ischemic coxarthropathy].

In the first part of their work, the authors present radiological, histopathological and experimental results showing that cartilage of the joint can be originally damaged by articular ischemia. In the second part, they analyze the clinical and radiological features of 40 cases of ischemic coxarthrosis, substantiated by histological examination: these are chronic coxarthropathies with changes in the cartilage without rupture of the femoral head but with medullary necrosis and often trabecular necrosis involving the head and the neck of the femur. These ischemic coxarthroses are most often well centered with a superior or supero-internal pinching and show few osteophytes. They constitute a group of coxarthrosis called "primitive", involving the structure because of a previous weakening of the cartilage.

Adult↗
PubMed1978

[Histopathology of bone lesions in 9 cases of algodystrophy of the hip].

The authors present the results of histo-pathological observations made in 9 cases of sympatic algodystrophy reflex of the hip, subjected to a punch biopsy of the head and neck of the femur. The punch biopsy was decided upon, either because of difficult diagnosis, or because of the abnormally long duration of the pain syndrome. In all cases, there were bone lesions. The most common were in the marrow tissue, with stasis (9 cases), fibrosis (7 cases) and necrosis at small, isolated points (5 cases). There was osteoclastic resorption in the bones in 3 cases, and rapid osteogenesis in 6 cases. The latter anomaly revealed the rapid reconstruction characterizing the syndrome. Finally, the authors comment on the relationship between algodystrophy and necrosis of the hip, and the advantages of punch biopsy.

Adult↗
PubMed1977

A study of the oxygenation of trochanteric bone blood and its correlation with the maximum intra-medullary pressure value in 85 cases of chronic coxopathy.

The authors carried out measurements of the gases (pH, PCO2, PO2, SaO2) on blood from the trochanter of 85 chronic hip diseases in 73 patients. Simultaneous measurements were made on the arterial blood and on the blood of the femoral vein of the same side. A statistically significant difference in blood PO2 and oxygen saturation between the group of necrosis of the femoral head and the group of osteoarthritic hips was found. There is a paradoxical oxygen hypersaturation in case of necrosis. This hypersaturation is observed to parallel the increase of the intramedullary pressure in the same bone area.

Carbon Dioxide↗
PubMed1977

[Etiopathogenesis of arthrosis; nosological consequences].

A nosological classification of arthrosis is proposed, consisting of two groups depending on whether the cartilage is intact (mechanical chondrosis) or altered (structural chondrosis). For both categories the principal aetiologies are mentioned. This aetiological differentiation has the aim of counteracting the facile diagnosis of primary arthrosis and is based on more elaborate diagnostic methods concerning the condition of the bone and cartilage.

Cartilage Diseases↗
PubMed1977

[Cytogenetics of Paget's disease of bone].

The authors studied the karyotype in blood and marrow of 34 patients with Paget's disease and compared the results with those of a control group of the same age. Structural abnormalities are more frequent in the blood than in the marrow, but there is no significant difference in comparison with the abnormalities in the control group. Ionizing radiations and drugs do not seem to be responsible for the abnormalities encountered. The numerical abnormalities are characterized by an increase in the number of hypodiploidies, particularly involving the chromosome groups A, B and D, whereas chromosomal damage affecting the C and G groups is less than normal. These abnormalities were encountered in a limited number of patients. The authors discuss the significance of these chromosomal abnormalities in the more general context of the genetics of Paget's disease.

Aged↗
PubMed1976

[Role of vertebral hyperostosis in cervical myelopathies].

The authors analysed the case histories of 40 patients with cervical myelopathy and were struck by the frequency of associated vertebral hyperostosis (Forestier and Rotès-Quérol disease). They found 17 cases in which dorsal vertebral hyperostosis was indiscutable and in which there was acquired stenosis of the cervical canal related to the bony proliferations that had developed on the anterior face of the cervical canal and to the type of cells described by Forestier and Rotes-Querol on the anterior and lateral faces of the vertebral column. According to the present authors these posterior growths occurred in a site that has not previously been described for hyperostosis. These growths are likened to those observed by Japanese neurosurgeons since 1960. Their particular interest concerns their role in pathology.

Adult↗
PubMed1976

[Chromatographic analysis of urinary amino acids in Paget's disease. II : clinical study].

The authors demonstrated in the urine of certain patients a peptide form of hydroxyproline and of glutamic acid. This peptide was found in patients with Paget's disease who presented clinical and laboratory signs of an evolutive episode and in other patients who presented restructuration of bone of a radiologicaly type. This peptide was one of the factors determining the increase in the total hydroxyprolinuria. The demonstration of the peptide provokes discussion as to its origin, and also of the possibility of using it as a biochemical parameter.

Adolescent↗
PubMed1975

[Osteochondritis dissecans and osteonecrosis of the lower end of the femur. Value of bone marrow functional exploration].

The authors report the results of 19 functional investigations carried out for osteochondritis in 11 cases, and osteonecrosis of the knee in 8 cases. The 8 cases of osteonecrosis all had hemodynamic disorders with increased pressure in the bone marrow and stasis due to circulatory obstruction. On the other hand, 5 cases of osteochondritis out of the 11 explored had no disturbance of marrow blood supply. However, of the 6 cases of osteochondritis with vascular disorders, there were 5 who had some other reason which might explain the disorder blood supply within the bone. It thus seems that one may contrast two types of disease: -One, characterized by an intra-osseous circulatory disorder for which one might reserve the terms osteonecrosis, which occurs in patients aged over 60 years, but which may be observed in juvenile forms. - The other, characterised by the absence of any hemodynamic disturbance and in which the foreign body seems to result from a very localised disorder which does not affect the bone marrow blood supply. One may use here the term, osteochondritis. We propose to substitute this physiopathological classification for the classical division based on age and on X-rays. Investigation of the blood supply of the bone, permits, as with strontium, early diagnosis at a pre-radiological stage.

Adolescent↗