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Biomedical subjects

J Amouroux

Publications and source records attributed to J Amouroux.

At least 109 records · Page 6Linked to original sources
PubMed1981

[Thyroid disorders during sarcoidosis (author's transl)].

A clinical, scintigraphic and hormonal study of the thyroid was performed in 50 patients with intrathoracic sarcoidosis. The patients were divided into two groups: T - : n = 32, no thyroid abnormality; T +, 18 cases, with thyroid disorders (9 moderate diffuse goitres, 2 thyroid nodules, 7 nodular goitres). All had normal T4, T3 and TSH levels, except one patient with Graves's disease. Scarce sarcoid granulomas were found in 3 out of 4 patients who underwent thyroidectomy. Dissemination, activity, type of sarcoid thoracic involvement were not different in the two groups. In contrast, T + group had higher seric IgG levels than T - group (p less than 0,05). The association of sarcoidosis and goitre is not fortuitous but thyroid enlargement and sarcoid diffusion do not seem interrelated. Auto-immune thyroiditis seems unlikely in our cases, according to the low frequency of thyroid auto-antibodies. We discuss the possible role of seric immunoglobulins in the constitution of thyroid hypertrophy with or without hyperthyroidism in sarcoidosis.

Adult↗
PubMed1980

[Diffuse interstitial pneumopathy associated with limited Sjögren's syndrome (author's transl)].

Diffuse interstitial pneumopathy was found to be associated with limited Sjögren's syndrome (i.e. without connective tissue involvement) in 5 women aged from 48 to 83 years. The respiratory symptoms (dyspnoea, unproductive cough and crepitations) appeared before the dry-eye-and-mouth syndrome was diagnosed in two patients and several years afterwards in three. Respiratory function studies showed a mixed restrictive and obstructive syndrome, perturbed Co transfer and increased total expiratory airways resistance. These changes reflected the underlying pathology, as revealed by bronchial and lung biopsies, which consisted of lymphocyte and plasmocyte infiltration and fibrosis of the interalveolar septa, peribronchial spaces and bronchial glands. Abnormal respiratory function tests in 5 other patients without any respiratory symptom suggest that subclinical and subradiological lesions of the lungs and bronchi are not uncommon in Sjögren's syndrome.

Aged↗
PubMed1980

[Chronic atrophic polychondritis. Report of three cases, with ultrastructural study by electron microscopy].

The authors report 3 cases of chronic atrophic polychondritis with clinical signs characteristic of the disease. The 3 patients had deafness of perceptive type, very severe in one case. In one case, the relationship between inflammatory rheumatism and rheumatoid arthritis is discussed. The 3 cases include a pathological study under the electron microscope of the cartilage of the ear. Certain ultrastructural peculiarities observed (dense perichondrocyte granules) are compared with the data in the literature.

Adult↗
PubMed1979

Comparative distribution of two antidepressant drugs (imipramine and indalpine) in the rat as determined by analog computer simulation.

A ten-compartment analog computer model is presented to determine the precise distribution and excretion of two antidepressant drugs, LM 5008 AND Imipramine. Eight patterns were simulated using experimental data and drug distribution in the two undetermined compartments were obtained by the analog model. Close agreement with existing experimental data lends confidence in the model as a valuable tool for predictions in a variety of therapeutic situations.

Animals↗
PubMed1979

[Data on the etiology of the liquid of broncho-alveolar lavage in mediastino-pulmonary sarcoidosis (author's transl)].

The cell population of the liquid of broncho-alveolar lavage of 44 cases of mediastino-pulmonary sarcoidosis was compared to that of 12 normal controls, of 14 controls with a localized pulmonary affection, who underwent lavage in healthy contro-lateral segment, and of 33 patients with various diffuse interstitial pneumopathies, except hypersensitivity ones. In sarcoidosis, the total number of cells is significantly higher than in controls; such is the case for neutrophils. It is also higher for lymphocytes in sarcoidosis: 21.8, than in controls: 7.8, or in patients with other diffuse interstitial pneumopathies: 10.3. It is independent of the disease radiological stage, but closely related to its degree of activity; it showed important variations, going from 3 to 50%. The observation of a normal level of lymphocytes is not enough to exclude the diagnosis of sarcoidosis.

Adult↗