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Biomedical subjects

J Amouroux

Publications and source records attributed to J Amouroux.

At least 91 records · Page 5Linked to original sources
PubMed1984

Thymus function in patients with resectable lung carcinoma.

A series of 43 patients (median age 57 years, range 39-73) underwent biopsy of the thymic area during resection for primary lung cancer (16 with negative nodes and 27 with positive nodes). In 22 cases in which study of lymphocyte subpopulations was possible T6 precursor thymocytes were found (mean 57%). T4 and T8 cells were present in proportions of 53% and 47%, respectively, equally distributed between T6 and T3 cells. A well-defined lobular structure was found in 11 cases and active thymic tissue with poorly defined lobules in 21 cases. There was no correlation of active thymus tissue either with age or with lymph node status. It is hypothesized that thymic tissue undergoes regeneration in response to tumor development, 50% of thymocytes being of the suppressor type in early tumors. Thymic structure in advanced cancer has not yet been studied.

Adult↗
PubMed1984

The relationship between disease duration and noninvasive pulmonary explorations in sarcoidosis with erythema nodosum.

In order to investigate the initial course of pulmonary sarcoidosis, the following investigations were carried out in 14 nonsmoking patients with Logfren 's syndrome 3 to 12 wk after the onset of erythema nodosum (EN): bronchoalveolar lavage (BAL) (cellular and protein components), serum assays of lgG and of the activity of angiotensin-converting enzyme (SACE), and pulmonary function tests. These results were related to the disease duration, estimated by the time lapse separating the onset of EN from the investigations. All patients but one showed a large increase in the percentage of lymphocytes (%-L) in BAL fluid (more than 30%). Although each patient was evaluated only once, and thus this work was not an actual longitudinal study, a linear relationship between lymphocyte count per milliliter of recovered fluid during BAL (L-count) and disease duration was found during the first 8 wk (r = 0.78, p less than 0.01), suggesting a fast-developing alveolitis. The delayed rise in SACE level may indicate a secondary activation of macrophages; SACE and L-count were well related, either up to 8 wk (SACE versus L-count: r = 0.84, p less than 0.01) or up to 12 wk (SACE versus L-count: r = 0.61, p less than 0.01). Serum lgG levels were found to follow the L-count (serum lgG versus L-count: r = 0.79, p less than 0.01) and appeared to be a reliable index of disease activity. Respiratory function showed a univocal pattern, with a marked decrease in all of the patients in carbon monoxide diffusing capacity (DLCO), contrasting with normal lung volumes.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

[Temporal arteritis with necrotizing angiitis of the muscles].

A 71 year old woman with typical giant-cell arteritis experienced myalgia of the legs immediately at the end of steroid therapy, 3 months after the onset of her illness. Muscle biopsy showed a focal necrotising panarteritis whereas the muscular fibres remained unchanged. The patient is now asymptomatic after 3 years' follow-up on prednisolone therapy (10 mg per day). This case demonstrates that giant cell arteritis can also involve the muscular arteries.

Aged↗
PubMed1984

[Nonspecific chemotactic response of macrophages, lymph node status and prognosis in operable cancers of the lung and breast].

Using a technique developed in our department, we studied the macrophage chemotactic response "in vivo" to a non-specific stimulus in 125 patients with operable lung cancer and 56 patients with operable breast cancer. The response was compared to that of 45 normal controls and 54 patients with metastatic cancer. The results of the preoperative test were correlated with lymph node status determined postoperatively by pathologic examination and also with prognosis. The follow-up on these patients has now reached 60 months. The chemotaxis test has revealed subgroups with different prognoses among both the N+ and N- groups. Patients with N- status (both lung and breast) and a strong preoperative chemotactic response had a very high recurrence rate, above that of N+ patients. Among the N+ patients a subgroup with very limited lymph node involvement and a strong chemotactic response had a significantly better prognosis that the N group as a whole.

Breast Neoplasms↗
PubMed1983

[Multicentric reticulohistiocytosis. A new case].

Multicentric reticulohistiocytosis is a rare disorder of the skin and joints that possesses distinctive histologic findings. A case is reported with typical features, and ulceration, an unusual outcome of "skin" lesions.

Aged↗
PubMed1982

[Local and regional extension of breast carcinoma; report of one hundred and sixty-two cases. (author's transl)].

Following mastectomy for cancer, one hundred and sixty-two biopsy samples were examined to determine the frequency of tumoral lesions other than those of the main tumor. If tumoral remnants close to the excision zone or less than five cm from the main tumor are eliminated, 44.4 per cent of cases had other remote tumors. In the present series, the frequency of other tumoral lesions was far from negligible for small tumors, and increased when the main tumor had intraductal components and when four or more axillary lymph nodes were invaded. These results, which confirm those of other authors, have to be considered for effective treatment of breast cancers, even those of a small size.

Axilla↗
PubMed1982

Pulmonary sarcoidosis with an alveolar radiographic pattern.

Thirty-three cases of sarcoidosis (4.4% of 746 patients) showed an alveolar radiological pattern. A study of pulmonary function was carried out in 25 patients and compared with that of 46 patients with the interstitial radiological type of sarcoidosis. Twenty-two cases have been followed up from one to six years after the initial examination. The radiographic lesions were most often bilateral and included nodules greater than 15 mm with ill-defined margins or diffuse, infiltrative, non-retractile opacities with fluffy margins. Bilateral mediastinal lymph nodes were present in 27 patients. In 20 patients an associated reticulation was found on radiography. In four patients an open lung biopsy was done. The granulomatous nodules were identical to those found in other forms of sarcoidosis, although they were more confluent in the affected areas. Clinical and functional findings did not differ from those in the more common forms of sarcoidosis. Alveolar sarcoidosis has a sudden course. The alveolar radiological patterns always disappeared, with or without steroid treatment, while reticular patterns persisted in four patients. Rapid radiological changes were observed. Some functional abnormalities persisted in cases that were followed. It is concluded that alveolar sarcoidosis is a distinct acute form of sarcoidosis.

Adolescent↗
PubMed1982

In vivo nonspecific macrophage chemotaxis in cancer patients and its correlation with extent of disease, regional lymph node status, and disease-free survival.

We have used a test to evaluate macrophage migration in vivo, derived from the technique of Rebuck. The test is based on counting the absolute number of macrophages that migrate into an inflammatory site determined by a standardized superficial skin abrasion. It was applied to the study of macrophage migration in cancer patients in different clinical situations. Macrophage migration was virtually abolished in patients with metastatic cancer as compared to healthy controls. In patients with resectable breast and lung tumors, the test performed preoperatively correlated closely with lymph node status as determined by pathological examination after operation. Patients without lymph node involvement showed a significantly stronger response than did controls, whereas those with lymph node involvement had a diminished or even an abolished response. Distinctive subgroups were characterized among patients both with and without lymph node involvement on the basis of their macrophage response, and these subgroups proved to have distinctly different prognoses, particularly the patients without lymph node involvement with a poor macrophage response who had an unusually poor prognosis. It is concluded that this test shows potential for predicting the prognosis among categories of patients hitherto considered as homogeneous, although further evaluation in larger numbers of patients is necessary.

Adult↗
PubMed1981

[Sea urchin spines synovitis. A case report with positive pasteurellosis antigen intradermoreaction (author's transl)].

A case is reported of a 53 years old woman who injured proximal interphalangeal joint of the right fourth finger on a sea urchin spine. She developed an extensive arthritis after synovial biopsy with sequellar fourth and fifth paw fashioned fingers and a palmar fibrositis. The originality of this observation with typical clinical symptoms and characteristic synovial histology (giant cells granulomatous synovitis) is the combination of a pasteurellosis infection. The diagnosis of the last one can be based on the inoculation in extra-aquatic condition, the extension of arthritis and particularly the positivity of pasteurellosis antigen intradermoreaction.

Arthritis, Infectious↗
PubMed1981

[Pathologic anatomy of infectious osteoarthritis].

Infection of the joint with pyogenic organisms usually causes purulent arthritis the prognosis of which is linked to the severity of the bone, cartilage and ligamentous destruction. The tissue response to infection is moreover influenced by a certain number of factors such as the nature of the bacteria and, above all, the circumstances of onset of the infections. Considering the difficulties in diagnosis, special mention should be made of bone and joint infections with a torpid course.

Arthritis, Infectious↗