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Biomedical subjects

J Ameille

Publications and source records attributed to J Ameille.

At least 55 records · Page 3Linked to original sources
PubMed1985

Pulmonary polymorphic centroblastic type malignant lymphoma in a patient with lymphomatoid granulomatosis, Sjögren syndrome and other manifestations of a dysimmune state.

A case of lymphomatoid granulomatosis arising in a patient with a long history of dysimmunity is reported. The autopsy reviewed the final evolution into a high grade malignant lymphoma with IgM K immunoglobulin production and discovered in deep lymph nodes modifications similar to angio-immunoblastic lymphadenopathy.

Adult↗
PubMed1985

[Chemotherapy of bronchopulmonary and pleural adenocarcinoma. Apropos of 31 cases].

Between January 1978 and June 1983, 31 patients aged between 35 and 73 years, with an adenocarcinoma of the respiratory system (25 lung cancers and 6 pleural cancers) were treated by chemotherapy, either exclusively or following failure of surgery. In 21 patients, the treatment consisted of a combination of cyclo-phosphamide (600 mg/m2), adriamycin (40 mg/m2) and 5-fluoro-uracil (600 mg/m2) by intravenous injection, every four weeks. The other 10 patients received different treatments, but platinum salts were administered in only 2 cases. The treatment was fairly well tolerated (only 1 death due to toxicity), but the effectiveness remained disappointing: only 1 complete response (alive after 48 months), 2 partial responses and 4 stabilisations. The overall median survival was 9 months, with a mean survival of 11.6 months. The mean survival of the responder and stabilised patients was more than 21 months. These results lead us to recommend that, apart from randomised trials, chemotherapy should be stopped after the second course in the absence of at least a stabilisation of the disease, in which prolonged survivals are sometimes observed when treatment is limited to purely symptomatic measures.

Adenocarcinoma↗
PubMed1985

[Respiratory pathology induced by inhalation of hair lacquer].

On the basis of a critical analysis of the literature, the authors review the various respiratory lesions imputed to the inhalation of hair lacquers. Pulmonary thesaurismosis is alleged to result from accumulation in the pulmonary parenchyma of non-biodegradable macro-molecules, such as PVP. Only isolated cases have been published and the true existence of this disease remains to be confirmed, in the absence of convincing epidemiological data as well as the lack of experimental reproducibility. Chronic inhalation of hair lacquers may, however, be responsible for bronchial irritative manifestations and obstruction of the small airways, in particular in hairdressers. Increase in the relative risk of bronchopulmonary carcinoma has not been proven.

Acute Disease↗
PubMed1984

[Diffuse interstitial pneumopathy during treatment with gold salts].

A case of severe diffuse interstitial pneumonia is reported in a 69 year old after 5 weeks treatment with gold salts. Regression of symptoms on withdrawal of gold salts and under steroid therapy, the similarity with previously published cases, the absence of another cause lead us to incriminate the gold salts. The case is documented with optical and electronic microscopic studies of transbronchial biopsy and repeated examination of bronchoalveolar lavage fluid. A general review of the literature is included with a critical discussion of the physiopathogenic mechanisms. The results of the examination of the bronchoalveolar lavage fluid are further evidence in favour of cell-mediated hypersensitivity reaction.

Acute Disease↗
PubMed1983

[Small-cell anaplastic bronchopulmonary cancers. Prognostic and therapeutic review apropos 49 cases].

This retrospective study of 49 patients with small-cell broncho-pulmonary carcinoma showed the principal prognostic factor to be the response to chemotherapy: an initial treatment association of cyclophosphamide (800 mg/m2), adriamycin (60 mg/m2), methotrexate (40 mg/m2) and CCNU (60 mg/m2) every four weeks was used in 40 patients, out of 46 patients who underwent chemotherapy. All cases were followed up for a minimum of 6 months except 2 who were lost to follow-up; there are 9 survivors, all of whom initially had an apparent complete remission: the extension of the disease seemed to be of less prognostic significance than the response to treatment. The response rate to this protocol was 84 p. cent with 52 p. cent apparent complete remissions. The mean global survival rate was 9 months (mean survival rate of treated patients: 11.46 months). Some patients with disseminated carcinoma initially had very prolonged survival. The association of a final session of thoracic radiotherapy seemed to be useful (the 4 patients who underwent radiotherapy after 8 to 12 sessions of chemotherapy are still alive after an average of 18 months follow-up with no signs of recurrence).

Adult↗
PubMed1983

[Erasmus syndrome in a dental technician. Importance of the prevention of occupational hazards].

A case of generalised scleroderma is reported in a dental technician exposed to the risk of silicosis. A study of the occupational toxic risks in this patient showed pulmonary overload with silica and metallic particles composed of chromium, cobalt and tungsten. The job also involved the handling of vinyl chloride and its stable polymer. This chemical is known to give rise to scleroderma-type skin disease. The relationship between these occupational factors leads to a difficult physio-pathological problem and justifies preventative measures, even though they may be costly and demanding.

Dental Technicians↗
PubMed1982

[Is annual X-ray examination of the chest still justified in industrial medicine?].

Between 1975 and 1979, 137.526 annual X-ray examinations of the chest were performed among the employees of a large Paris administration. Fifty-four cases of tuberculosis, 28 cases of sarcoidosis, 10 cases of bronchial carcinoma and 26 miscellaneous chest diseases were detected. This study confirms the inadequacy of radiological examination for detecting chronic obstructive bronchopulmonary conditions. The small proportion of tuberculosis (0.39 p.1000) and bronchial carcinoma (0.07 p.1000) revealed by this method suggests that it should be reserved to high risk patients.

Carcinoma, Bronchogenic↗
PubMed1982

[Serum angiotensin converting enzyme activity in sarcoidosis. A review of seventy cases].

The serum angiotensin converting enzyme (ACE) activity was assayed in seventy untreated patients with sarcoïdosis. Results were considered abnormal if they exceeded 34,5 U/ml. (SEM + 250). Increased ACE activity was found in 55,7% of the patients. Most of these patients had either Stage II or disseminated disease. Significant decreases in ACE activity always occurred during remission, whether spontaneous or induced by corticosteroids. In most patients with persistant roentgenologic features ACE activity was still high six months after onset. No correlations were found between serum ACE activities and lymphocytosis in bronchial washing samples. We conclude that, while serum ACE activity assays are not of significant diagnostic utility in patients with sarcoidosis, they are helpful for monitoring the course of the disease.

Adult↗