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J Alwasiak

Publications and source records attributed to J Alwasiak.

72 records · Page 4Linked to original sources
PubMedDate not supplied

Neuroblastic differentiation of metastases of medulloblastoma to extracranial lymph node: an ultrastructural study.

Extracranial metastases of a poorly differentiated medulloblastoma in a 12-year-old girl were studied by thin section transmission electron microscopy and immunohistochemistry. The primary tumor did not show any differentiation as revealed by immunohistochemistry. On the contrary, the metastatic tumor cells and their processes disclosed features of neuroblastic differentiation when examined ultrastructurally: microtubules, dense core vesicles, and abortive synaptic ribbons. Several dystrophic neurites containing altered subcellular organelles were also found. Furthermore, few processes contained concentric arrays of paired membranes. This report is the first to clearly show the neuronal differentiation of extracranial metastases of poorly differentiated medulloblastoma. We speculate that metastases of medulloblastomas outside the neuraxis behave analogously to medulloblastoma explants cultured in vivo.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Primitive neuroectodermal tumors: ultrastructural and immunohistochemical studies.

We report here ultrastructural and immunohistochemical studies of neuroblastic differentiation in the retrospective (n = 17) and prospective (n = 26) series of primitive neuroectodermal tumors (PNETs). By electron microscopy, neuritelike structures containing parallel-oriented microtubules, adhesive plaque junctions, and pleomorphic dense-core vesicles were found in the majority of tumor specimens while synaptic specializations were very rare. By immunohistochemistry, synaptophysin appeared to be the most reliable marker for neuroblastic differentiation present in the most reliable marker for neuroblastic differentiation present in the majority of tumors, while 200 kDa neurofilament protein was immunovisualized in a lower proportion of tumors. Glial fibrillary acidic protein (GFAP) was expressed in both reactive astrocytes and in a small proportion of otherwise typical neoplastic cells. We conclude that the majority of PNETs revealed diverse differentiation and that electron microscopy is still the most reliable tool for its detection followed by immunohistochemistry for synaptophysin.

Adolescent↗
PubMedDate not supplied

[Thymoma and thymoma-like tumors of the anterior mediastinum--therapeutic problems in observed patients].

In the last years, 11 patients with tumors of anterior mediastinum were treated at the Oncologic Centre in Lódź. Lymphocytic-epithelial thymoma was diagnosed in 6 patients whereas thymoma was suspected in 5 patients. Therapy was a problem mainly in these 5 patients, especially if lymphoma was considered in the differential diagnosis. The authors suggest that therapy should start with cytostatic agents in all patients with mediastinal tumors and morphology which not justifies thymoma diagnosis. Radiotherapy may follow in these cases in which 1-2 chemotherapy cycles failed.

Adult↗
PubMedDate not supplied

[Favorable outcome using indomethacin in a case of temporal arteritis].

The authors described a case of temporal arteritis in which only biopsy of the artery made the correct diagnosis possible. The patient had contraindications to steroid treatment and thus a trial of Metindol therapy was undertaken. After the treatment a rapid regression of symptoms occurred.

Aged↗
PubMedDate not supplied

[Primary malignant lymphoma of the central and peripheral nervous systems].

The authors present a case of malignant lymphoma in a man aged 64 years. Neoplastic infiltrations mainly in the form of perivascular accumulations were limited to the central nervous system (both central and peripheral). In the histological examinations of internal organs including lymph nodes and spleen no neoplastic tissue was found.

Brain↗