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Biomedical subjects

J Abulafia

Publications and source records attributed to J Abulafia.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Cutaneous mastocytosis in twins].

The case of a pair of fraternal twins of seven months of age with cutaneous Mastocyte disease is presented. A brief historical survey of this condition is made. The histological picture is described with special emphasis on the mastocyte and its physiopathology. A description of the clinical aspect of the Pigmentous Urticaria in children and a brief reference to the other clinical forms of Mastocyte disease in its localized and systemic manifestations are presented. The different etio-pathogenic genetic theories related to this disease are considered, on account of the occurrence of this condition in members of a same family and in identical and fraternal twins. A revision of cases available up to date is made. The conclusion is that the etio-pathogenic problem is not solved yet, although the Mastocyte disease is considered as depending on a hereditary factor, not clearly defined yet, predisposing to this condition.

Diseases in Twins↗
PubMed1980

[Melanoma (Hutchinson's lentigo maligna) having spontaneous regression. A case of immunologic importance].

I. A brief description is given of the general aspects of skin melanomas, including some personal observations. II. Immunologic facts are mentioned demonstrating: A) The existence of specific circulating antibodies demonstrated by immunofluorescence techniques, by the useful action of blood from patients with duly controlled melanoma injected into other melanoma patients, and by the verification that blood serum from a melanoma patient inhibits cultures thereof. B) As regards cell-mediated immunity, this is normal when a melanoma cure is obtained, and abnormal when no cure takes place. C) There exist melanoma remissions in patients treated with specific or non-specific (BCG) antigens. Spontaneous regression has also been observed in some melanomas. III. A case is presented: a) with spontaneous regression of facial malignant lentigo; b) manifestation of a cervical lymph node metastasis after the primitive tumor had subsided; c) low-degree cell-mediated immunity recuperated spontaneously in an exaggerated manner after radical neck dissection in which none of the lymph nodes proved metastatic; d) manifestation of herpes zoster while the patient presented her best immunologic index; and 2) 11 years' survival since the melanoma made its appearance, and more than 2 years (up to March 1979) since the manifestation of the lymph node metastases.

Aged↗
PubMed1979

Oral florid papillomatosis (verrucous carcinoma).

1. Florid Papillomatosis (FP) seems to be another form of verrucous carcinoma. 2. Besides the mouth, FP can be found in the larynx, nose, genitalia, skin, etc. 3. FP would appear to be a carcinoma with a low degree of malignancy, and is locally aggressive. They do not cause generalized metastases and rarely metastasize locally. 4. In the mouth, the lesions, either single or multiple, usually occur in adult men. The most frequent sites are the buccal mucosa and the alveolar-gingival area. They develop on a healthy mucosa, or on preexisting lesions, namely, leukoplakia, atypical lichen, abrasive cheilitis and traumatic ulcers. FP may cause fistulas and jaw destruction. 5. Histologically, three stages can be recognized: type I, with acanthosis and papillomatosis, etc., type II, with the aspect of an in situ carcinoma, and type III, carcinoma-like in aspect but with some characteristics of FP. 6. Ten percent of the cases may develop an anaplastic carcinoma or may become associated with other types of carcinomas in other organs and near the area where the FP appeared. 7. Predisposing factors are the same as those for classical carcinomas (especially smoking and chewing tobacco or betel). FP may develop on preexisting lesions similar to those described for regular carcinomas. No virus has been isolated. Some authors believe FP is a precancerous condition; we think it is a cancer with a low degree of malignancy. 8. Treatment should be initiated with cytostatic drugs, especially methotrexate, followed by electrocoagulation, radium implantation and surgery. If the lesions are small in size, methotrexate is not required. If the lesions are large or there is bone destruction, surgery is the treatment of choice after methotrexate and sometimes high-voltage therapy with 60Co. 9. A cure rate of 75% can be obtained in properly treated cases.

Adolescent↗
PubMed1978

Squamous cell carcinoma of the nail bed.

A case is presented of squamous cell carcinoma developed from carcinoma in situ of the nail bed of the first finger in a 79-year-old patient. Stress is laid upon the importance of the differential diagnosis. Surgery is considered the treatment of choice for this uncommon condition.

Aged↗
PubMed1978

[Scleroatrophying and degenerative keratodermic genodermatosis of the extremities].

A case of a picture described by Huriez et al. under the title of scleatrophying and keratodermic genodermatosis of the limbs usually degenerative is presented. In the genealogic study it was observed that seven out of the sixteen members that belonged to this primary family group were affected or probably affected and it is stressed that one of them died from metastasis of spinocellular epithelioma.

Basal Cell Carcinoma↗
PubMed1978

[Keratodermic genodermatosis with hydrocystomas, miliary cysts, xanthelasmas, nail and dental dystrophies, and basal cell epitheliomas].

Two cases of a condition including palms and soles keratoderma, ectodermal dysplasias and basal cell epitheliomas are reported by the authors, with clinical, genetical and pathological data. The condition is called Keratodermal Genodermatose with hydrocystomas, milium cysts, xanthelasma, dental and nail dysplasias and basal cell epitheliomata (Borda's syndrome).

Abnormalities, Multiple↗
PubMed1978

[Erythema elevatum diutinum].

Three cases of Erythema Elevatum Diutinum are reported and a revision of the literature about this subject is made. The authors described extensively the general and cutaneous clinical picture. They precise the histological characteristics and mention other dermatological proceses from which this entity must be differentiated. Finally the ethiology and treatment of this clinical picture are discussed.

Adult↗
PubMed1977

[Benign circinated pityriasic erythema in children].

The case is report of a boy aged 6 months whose dermatosis had set in suddenly 15 days before in the form of large round circinate patches on the face, thorax, abdomen, dorsum and extremities. These patches were limited by a slightly elevated erythematous border, the inside of which was constituted by collarette-like epidermal desquamations with central parakerotosis. The patches impairment was observed in the child's general condition. A histopathological study was carried out.

Diagnosis, Differential↗
PubMed1977

[Epidermotropic reticulosis (Woringer-Kolopp disease)].

The Woringer-Kolopp's disease must be considered a clinical-pathologic variant of mycosis fungoides. It is characterized by heterogenous clinical features and a peculiar histological aspect given by the cellular infiltration of the epidermis. The orgin of the reticular elements is discussed. Though some investigators think they originate in the dermis, others consider their origin to be "in situ". The evolution and prognosis are not well defined, as is the case with the hyperplastic, heteromorphic and polymorphic reticuloses. The case presented has had Hodgkin's disease and then developed a picture of pagetoid reticulosis.

Diagnosis, Differential↗
PubMed1976

[Nonvenereal lymphangitis of the penis].

Two personal cases of Non venereal Lymphangitis of the Penis are presented in 23 and 28 men, and 38 cases from the literature are reviewed. This benign self-limiting condition is not too well known among dermatologists and urologists. The clinical changes, in particular noted by palpation are characteristic: painless firm cartilaginous cord freely movable behind the corona of glans penis in the coronary sulcus. The inguinal lymph nodes are not involved. The microscopic features in one of our patients demonstrated that the lesion results from cystic dilatation of secondary organization of the thrombus. The etiology is unknown. We favour the mecanical trauma as an important factor based on excessive sexual activity of the patients.

Adult↗
PubMed1976

[Inflammatory verrucous epidermal nevus (IVEN)].

From the original description of Altman and Mehregan (1971) a new clinical type of linear nevus is known as inflammatory linear verrucous epidermal nevus (ILVEN). Two girls of 5 and 4 years of age are reported. One of them had good therapeutical results with the use of trichloroacetic acid. The clinical and histopathological aspects of this nevus are reviewed and the differential diagnosis should be done with: lichen planus, lichen striatus, linear psoriasis, zoniform dermatitis, naevus unius lateris.

Child, Preschool↗