Biomedical subjects
Publications and source records attributed to J Abulafia.
The case of a patient with thoracic abdominal and left arm, migratory erythema-edematous plates over a space of three years is described. The histopathologic features reveal a eosinophilic panniculitis due to probable larva migrans (gnathostomiasis). This appears to be the first report on the subject because we have not found any reference to the subject in Argentina bibliographic search.
Male patient, aged twenty-six years. Having an eight-and-a-half-year- old dermatosis of localized evolution on scalp, under arms, thighs, pubis and legs, characterized by inflammatory papules and follicular and extra-adnexial pustules, tiny scars and lack of hair in the affected areas. The authors present a representative case of "depilating folliculitis" of (Arnozán and Dubreuilh) stressing the following: Uncommon frequency in our country but frequent in warmer climates where it is observed mainly among peasants and sugar-cane workers. Wide-depilated areas principally in folds. Seasonal outbreak. Good response to treatment. A revision of the theme is made emphasizing the histopathologic pathogenesis.
In a previous work, Segers and adl., the histological and histochemical study of the features of cellulitis is performed, expliciting the importance in this lipodystrophy of microangiopathy PAS positive. As a complement of that work, we study a group of 254 patients, all females, which came to us to be treated for their cellulitis, general clinical and local laser therapy. All of these patients presenting microangiopathy of their dermohipodermic capillary vessel confirmed by biopsy. These cases were divided in four groups according to the existence or not family antecedents of diabetes mellitus, and positivity or negativity to the test of glucose overcharge, sensibilized with corticoid (Fajans-Conn). The results are extensively described and discussed, and considerations are made referring to the aetiopathogenesis of both entities, diabetes and micro-pathological angiopathy, that could be generically and/or immunologically related.
In a group of 130 patients carriers of cellulite, that were subjected to a general clinic treatment and local treatment of laser-therapy, the authors, previous to the therapeutics, made an anatomopathologic study of the skin and the adipose tissue. The biopsies were done on patients of the feminine sex, confirming that all these cases presented the histopathologic and histochemical features of cellulite in their dermo-hypodermic tissue. A full study of intolerance to carbohydrates; lipidic, proteic and hormonal metabolism was also performed in all patients. Comparing the different parameters, the authors emphasize the multiple pathogenic varieties of the illness, and the possibility of future risk of macroangiopathy and coronariopathy.
1. Florid Papillomatosis (FP) seems to be another form of verrucous carcinoma. 2. Besides the mouth, FP can be found in the larynx, nose, genitalia, skin, etc. 3. FP would appear to be a carcinoma with a low degree of malignancy, and is locally aggressive. They do not cause generalized metastases and rarely metastasize locally. 4. In the mouth, the lesions, either single or multiple, usually occur in adult men. The most frequent sites are the buccal mucosa and the alveolar-gingival area. They develop on a healthy mucosa, or on preexisting lesions, namely, leukoplakia, atypical lichen, abrasive cheilitis and traumatic ulcers. FP may cause fistulas and jaw destruction. 5. Histologically, three stages can be recognized: type I, with acanthosis and papillomatosis, etc., type II, with the aspect of an in situ carcinoma, and type III, carcinoma-like in aspect but with some characteristics of FP. 6. Ten percent of the cases may develop an anaplastic carcinoma or may become associated with other types of carcinomas in other organs and near the area where the FP appeared. 7. Predisposing factors are the same as those for classical carcinomas (especially smoking and chewing tobacco or betel). FP may develop on preexisting lesions similar to those described for regular carcinomas. No virus has been isolated. Some authors believe FP is a precancerous condition; we think it is a cancer with a low degree of malignancy. 8. Treatment should be initiated with cytostatic drugs, especially methotrexate, followed by electrocoagulation, radium implantation and surgery. If the lesions are small in size, methotrexate is not required. If the lesions are large or there is bone destruction, surgery is the treatment of choice after methotrexate and sometimes high-voltage therapy with 60Co. 9. A cure rate of 75% can be obtained in properly treated cases.
A case is presented of squamous cell carcinoma developed from carcinoma in situ of the nail bed of the first finger in a 79-year-old patient. Stress is laid upon the importance of the differential diagnosis. Surgery is considered the treatment of choice for this uncommon condition.
A case of a picture described by Huriez et al. under the title of scleatrophying and keratodermic genodermatosis of the limbs usually degenerative is presented. In the genealogic study it was observed that seven out of the sixteen members that belonged to this primary family group were affected or probably affected and it is stressed that one of them died from metastasis of spinocellular epithelioma.
Two cases of a condition including palms and soles keratoderma, ectodermal dysplasias and basal cell epitheliomas are reported by the authors, with clinical, genetical and pathological data. The condition is called Keratodermal Genodermatose with hydrocystomas, milium cysts, xanthelasma, dental and nail dysplasias and basal cell epitheliomata (Borda's syndrome).
Three cases of Erythema Elevatum Diutinum are reported and a revision of the literature about this subject is made. The authors described extensively the general and cutaneous clinical picture. They precise the histological characteristics and mention other dermatological proceses from which this entity must be differentiated. Finally the ethiology and treatment of this clinical picture are discussed.
The case is report of a boy aged 6 months whose dermatosis had set in suddenly 15 days before in the form of large round circinate patches on the face, thorax, abdomen, dorsum and extremities. These patches were limited by a slightly elevated erythematous border, the inside of which was constituted by collarette-like epidermal desquamations with central parakerotosis. The patches impairment was observed in the child's general condition. A histopathological study was carried out.
The Woringer-Kolopp's disease must be considered a clinical-pathologic variant of mycosis fungoides. It is characterized by heterogenous clinical features and a peculiar histological aspect given by the cellular infiltration of the epidermis. The orgin of the reticular elements is discussed. Though some investigators think they originate in the dermis, others consider their origin to be "in situ". The evolution and prognosis are not well defined, as is the case with the hyperplastic, heteromorphic and polymorphic reticuloses. The case presented has had Hodgkin's disease and then developed a picture of pagetoid reticulosis.
Two personal cases of Non venereal Lymphangitis of the Penis are presented in 23 and 28 men, and 38 cases from the literature are reviewed. This benign self-limiting condition is not too well known among dermatologists and urologists. The clinical changes, in particular noted by palpation are characteristic: painless firm cartilaginous cord freely movable behind the corona of glans penis in the coronary sulcus. The inguinal lymph nodes are not involved. The microscopic features in one of our patients demonstrated that the lesion results from cystic dilatation of secondary organization of the thrombus. The etiology is unknown. We favour the mecanical trauma as an important factor based on excessive sexual activity of the patients.
From the original description of Altman and Mehregan (1971) a new clinical type of linear nevus is known as inflammatory linear verrucous epidermal nevus (ILVEN). Two girls of 5 and 4 years of age are reported. One of them had good therapeutical results with the use of trichloroacetic acid. The clinical and histopathological aspects of this nevus are reviewed and the differential diagnosis should be done with: lichen planus, lichen striatus, linear psoriasis, zoniform dermatitis, naevus unius lateris.
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