Biomedical subjects
Publications and source records attributed to J A Jordan.
The technique for and results of 100 laparoscopic ventrosuspensions are described; patients were followed for an average of 40 months and in all but 11 the uterus was anteverted at the end of the follow-up period. The presenting symptoms of dyspareunia, dysmenorrhoea or sacral backache were almost always improved as a result of the operation.
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The replication of type 2 herpes simplex virus in human endocervical tissue in organ culture was investigated. The temporal profile of virus replication was related to the initial virus inoculum; high input inocula induced a rapid increase in virus titre while lower multiplicities induced a more slow-rising increase in virus titre. Our evidence suggested that explants were capable of initiating and supporting virus replication for at least 2 weeks following establishment of the culture. Virus yields were optimal when explants were cultured at 37 degrees and in serum-supplemented medium. Explants also supported the replication of type 1 herpes simplex virus and a "non-human" herpes simplex virus (pseudo-rabies virus). The optimal conditions for replication of type 2 herpes simplex virus in human endocervical explants have been established and will provide a model permitting precise investigation of lytic or other virus-cervical cell interactions and their possible relationship to herpes virus-induced pre-invasive carcinoma of this organ.
The surface ultrastructure of normal, malignant and dyskaryotic exfoliated cervical squamous cells was examined with the Scanning Electron Microscope (SEM). Normal and malignant cells were found to have very similar surfaces to those seen on similar cells in a biopsy specimen. Dyskaryotic cells, however, showed a large range of surface features and dyskaryotic cells that looked identical at light microscopy could be subdivided into three groups by examining their ultrastructural features.
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Follow-up of 151 women who had been sterilized for social or gynaecological reasons one to three years earlier showed that 146 were completely satisfied with the results of the operation on their health and on their sexual relationships with their husbands. The five who were dissatisfied either wished they could still conceive or found the operation had not produced the effect hoped for. On the basis of this study we believe that adverse psychiatric sequelae of sterilization can be kept to a minimum with careful selection of patients. Women should be over 30 or if younger should have had two or more children, and the operation should not be performed at childbirth, in the neonatal period, or during a postabortive depression.