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Biomedical subjects

J A Jordan

Publications and source records attributed to J A Jordan.

At least 91 records · Page 5Linked to original sources
PubMed1985

Complications of cone biopsy related to the dimensions of the cone and the influence of prior colposcopic assessment.

A retrospective study of the complications of cone biopsy showed that among 915 women examined between the years 1976 and 1982, 121 (13%) had primary or secondary haemorrhage, 153 (17%) cervical stenosis and 39 (4%) subsequent infertility or an abnormal pregnancy. Cervical stenosis was commonest among women who had had long cones removed. Stenosis occurred more often in the group of women who had been assessed by colposcopy before operation but this was due to the fact that prior colposcopy selected a favourable group of patients with lesions of limited extent that were susceptible to treatment by local destructive therapy, so that prior colposcopic assessment resulted in the removal of longer cones.

Adult↗
PubMed1985

The treatment of cervical intraepithelial neoplasia by laser vaporization.

Of 711 women with cervical intraepithelial neoplasia (CIN) treated by laser vaporization 675 (95%) remain colposcopically and cytologically free from disease after a median follow-up of 20 months. Thirty-six patients needed other forms of treatment to eradicate suspected residual disease. One patient presented with invasive carcinoma of the cervix 34 months after treatment with the carbon dioxide laser. It is concluded that in selected cases laser vaporization is an effective method of treating pre-invasive disease of the cervix.

Adolescent↗
PubMed1985

The management of cervical intraepithelial neoplasia by coagulation electrodiathermy.

Of 140 women with cervical intraepithelial neoplasia treated with a single application of coagulation electrodiathermy, 123 (88%) remain cytologically free of disease after a median follow-up of 3 years. The new squamocolumnar junction was colposcopically visible in 70% of the 130 patients assessed after treatment. In 15 of 17 women requiring further treatment, residual disease was suspected at the time of the first postoperative assessment. The incidence of significant morbidity following this procedure was 4%. In selected patients coagulation electrodiathermy is an effective method of treating pre-invasive disease of the cervix.

Adult↗
PubMed1984

The congenital cervicovaginal transformation zone in young women exposed to diethylstilboestrol in utero.

Twenty-seven young women exposed in utero to diethylstilboestrol have been studied for greater than 24 months. Serial study of the cervi-covaginal transformation zone has been by the non-invasive techniques of cytology, colposcopy and scanning electron microscopy. Minimal change has been noted in aceto-white areas within the transformation zone and, although some progressive glycogenation has been observed, this has never been to the stage of fully glycogenated epithelium. Scanning electron microscopy has shown maturation of the epithelium although there has been some slowing or arrest of the process at the stage of immature squamous epithelium. The neoplastic potential of this epithelium is discussed.

Abnormalities, Drug-Induced↗
PubMed1984

The congenital cervicovaginal transformation zone in sexually active young women.

A total of 110 sexually active teenage girls was screened cytologically and colposcopically; 71 of them had areas of aceto-white epithelium within the cervicovaginal transformation zone. Of these 54 had long-term follow-up and over a mean period of 36 months the aceto-white epithelium was observed to disappear in 26. In the remaining 28 girls aceto-white areas persisted largely unchanged over the period of follow-up. The characteristics of these persistent aceto-white areas are documented and suggestions with regard to their origins and significance are made.

Adolescent↗
PubMed1984

Benign cervicovaginal deformities in young women not exposed to diethylstilboestrol.

During a 2-year period six women have been identified with benign cervicovaginal deformities of the type normally associated with diethylstilboestrol (DES) exposure in utero. In none of them could such a hormonal history be identified. It is suggested, in view of these findings, that benign cervicovaginal deformities are not unique to women exposed to DES in utero and some possible reasons why they have never previously been reported are presented.

Adolescent↗
PubMed1984

The management of vaginal intraepithelial neoplasia after hysterectomy.

Twenty-three patients with vaginal intraepithelial neoplasia (VaIN) presented between 6 months and 13 years after hysterectomy for cervical intraepithelial neoplasia. All were discovered by cytological follow-up, were colposcopically assessed and diagnosis confirmed by histological examination before treatment. The CO2 laser was used as the initial treatment in 14, but only six remain free of disease after mean follow-up of 30 months. The reasons for the disappointing results with this form of therapy are discussed and it is suggested that its use may be inappropriate in the management of VaIN following hysterectomy as atypical epithelium may frequently be inaccessible as a result of being sequestered above the vault suture line or hidden in the recesses of the angles of the vaginal vault.

Adult↗
PubMed1982

Effects of the climacteric and sequential mestranol and norethisterone on the cervix and genital tract.

The effects of the climacteric and sequential mestranol and norethisterone on the epithelium of the cervix and genital tract were determined in 12 postmenopausal women. Before treatment the squamocolumnar junction was visible in only six of the 12 women, but after treatment with sequential mestranol and norethisterone the squamocolumnar junction became visible due to a minor degree of eversion. Mucus, which was always absent before therapy, was always seen afterwards and any atrophic effects were reversed by therapy within 3 months. The effects of oestrogen and progestogen deficiency were more easily seen by scanning electron microscopy (SEM) than with conventional histology. Before treatment six of the nine women studied by SEM had a cervix covered by mature squamous epithelium, but after therapy all the women had mature squamous epithelium. The pretreatment lateral vaginal wall and urinary sediment smears showed mainly immature squamous cells; this correlated poorly with the histology and SEM of the cervix. There was a good correlation between urinary sediment and lateral vaginal wall smears both before and after treatment.

Cervix Uteri↗
PubMed1981

Colposcopy in pregnancy. A twelve year review.

In a 12-year period, 195 patients with abnormal cervical cytology in pregnancy had colposcopy, of whom 73 had Grade IV cytology. Colposcopic findings in pregnancy correlated closely with the postpartum colposcopic assessment and this in turn predicted the ultimate histological diagnosis. Wedge biopsies were taken in two women in whom invasive disease could not be excluded colposcopically. Cone biopsy was avoided in all patients. No frank or occult invasive disease was missed but one patient was ultimately found to have a small focus of microinvasive disease six months post partum. Postpartum cytology gave a reasonable guide to the ultimate histology, although postpartum colposcopy was found to be of value even where cytology had by then reverted to normal.

Biopsy↗
PubMed1981

Treatment of preinvasive disease of the cervix by cone biopsy.

During the years 1952--1977, 646 patients with abnormal cervical cytology underwent one biopsy (595) or ring biopsy of the cervix. The histological diagnoses were invasive carcinoma 20 (3%) microinvasive carcinoma 16 (2%), carcinoma in situ and severe dysplasia 418 (65%), other dysplasias 149 (23%). The remainder, 43 (7%) had no demonstrable abnormality. Following biopsy 41 (7%) patients with non-invasive disease had abnormal cytology within a year of biopsy. A further 12 (2%) developed abnormal cytology after one year. These recurrences occurred up to 12 years after the initial treatment, and in one patient invasive squamous carcinoma has developed.

Biopsy↗