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Biomedical subjects

J A Andersen

Publications and source records attributed to J A Andersen.

At least 91 records · Page 5Linked to original sources
PubMed1984

Prognostic significance of residual cancer tissue after diagnostic biopsy in breast carcinoma. Three-year short-term results.

Among 3264 cases of breast carcinoma undergoing diagnostic biopsy and frozen section followed by one-stage mastectomy, the occurrence of residual cancer tissue (RCT) was evaluated as part of a prospective, nationwide trial in Denmark. RCT was defined by the presence of cancer left in relation to the biopsy cavity in the mastectomy specimen. A significantly higher cumulative recurrence rate within 3 yr was found in cases with residual cancer compared to cases without this finding. The difference was most pronounced in the premenopausal high-risk group. Therefore, RCT in the wall of the biopsy cavity is considered a prognostic hazard by itself.

Biopsy↗
PubMed1983

Antiestrogen treatment of postmenopausal women with primary high risk breast cancer.

The role of antiestrogen treatment in high risk postmenopausal patients with primary breast cancer is currently evaluated in a nationwide, prospective randomized trial conducted by the Danish Breast Cancer Cooperative Group. The primary treatment is total mastectomy and radiotherapy. As of February 1, 1982, 720 women were randomized to treatment with tamoxifen (30 mg daily for 1 year) and 691 women were randomized to no further therapy. Life-table analysis after 36 months shows a difference in recurrence rates of 9% (p = 0.19) in favor of the tamoxifen-treated patients. The material has been analyzed with respect to established prognostic factors such as age, degree of anaplasia, tumor size, and number of positive nodes. The rates of recurrent disease are lower in all subsets of patients treated with tamoxifen, but are only statistically significant in patients 50-59 years of age or with 4 or more positive lymph nodes. Regardless of treatment, ER negative patients have a 23% higher recurrence rate than ER positive patients after 18 months of analysis (p = 0.0033); this represents an approximate doubling of risk, and is independent of age, degree of anaplasia, tumor size, or lymph node status. With regard to PgR status, there is 11% higher recurrence rate in the PgR negative than in the PgR positive patients (p = 0.097).

Actuarial Analysis↗
PubMed1983

Giant basal cell carcinoma with metastasis and secondary amyloidosis: report of case.

Basal cell carcinoma of the skin is a slow growing relatively benign tumor usually located on the head and neck. Although rare, metastasis to lymph nodes or parenchymatous organs has been reported previously (1-9). We wish to add another case of metastasizing basal cell carcinoma of the skin, which presented certain unique features only rarely reported (1), namely complicating amyloidosis in the kidneys, the lymph nodes, the spleen and probably in the intestinal canal.

Amyloidosis↗
PubMed1982

Male breast at autopsy.

In a consecutive and unselected series of 100 male autopsies, the breasts were totally extirpated and histologically investigated. Gynecomasty was found in 55 cases, of which 48 were in healed and seven in still active, intermediate phase. All but two cases were bilateral. No clinical evidence of gynecomasty was established in any case. Thus, gynecomasty seems to be very common in men. In seven cases, severe intraductal epithelial hyperplasia was found, three of pagetoid and four of cribriform type. They belonged to the atypical hyperplastic--early intraductal carcinoma type. All cases were incidentally found and without known clinical relevance.

Adult↗
PubMed1982

Gynecomasty: histological aspects in a surgical material.

In a consecutive and unselected series of 83 patients operated upon for gynecomasty, the histological and related clinical aspects were studied. It was convincingly demonstrated that gynecomasty begins in an active proliferating phase and ends in a fibrous inactive phase. Contrary to previous authors we found it justified that the formation of lobules, indistinguishable from what is seen in the reproduceable age in the female breast, is not necessarily related to the administration of exogenic hormones. In five (6.5%) cases, typical multicentric foci of intraductal epithelial hyperplasia were demonstrated--of the atypical hyperplastic or early intraductal carcinoma type. It was concluded that the clinical significance of such morphological changes must not be overestimated.

Adolescent↗
PubMed1981

Cytoplasmic mucous globules in lobular carcinoma in situ. Diagnosis and prognosis.

In 87 cases of lobular carcinoma in situ, 64 contained mucous globules in more than 25% of the cells. Eighteen, however, had no or only a few mucous globules. In cancerization of lobules by duct carcinoma and in benign hyperplastic lesions, only a few cells contained mucous globules. The presence of many of these globules may be helpful in the diagnosis of lobular carcinoma in situ. On the other hand, the quantitation of mucous globules in lobular carcinoma in situ is not of prognostic significance.

Breast Neoplasms↗
PubMed1981

Selection of high risk groups among prognostically favorable patients with breast cancer.

In a prospective, nationwide, decentralized breast cancer project conducted by The Danish Breast Cancer Cooperative Group (DBCG) the recurrence rate within the first year after surgery was analysed in relation to tumor anaplasia. One thousand forty-eight patients met the requirements of eligibility, i.e. tumor size less than or equal to 5 cm with negative axillary nodes, and no skin or deep invasion. The recurrence rates in tumors with anaplasia Grades I, II, and III were 4, 9, and 14%, respectively (p = 0.001). Therefore, it seems possible, prospectively, among otherwise prognostically favorable patients, to select a group with high risk of recurrence which might benefit from adjuvant systemic therapy.

Anaplasia↗
PubMed1981

Metastases to the breast from extramammary carcinomas.

Metastases to the breast from extramammary carcinomas are rare. Only about 200 cases are reported in the literature. Fifteen additional cases are presented here and the literature is reviewed. Two of the patients has primary thyroid carcinoma, two adenocarcinoma of the colon, three bronchogenic carcinoma, four malignant melanoma, one a squamous cell carcinoma of the oesophagus, one an adenocarcinoma of the stomach, one a renal cell carcinoma and one a carcinoid of the terminal ileum. In three cases the breast lesion was the first manifestation of an extramammary cancer. Six of the patients died of disseminated cancer shortly after the breast metastasis was diagnosed. Although breast metastasis may be suspected clinically, exact histological diagnosis is important in order to avoid unnecessary surgical treatment and to guide further therapy.

Adult↗
PubMed1981

Involvement of the nipple and areola in breast cancer. Value of clinical findings.

In a series of 80 consecutive mastectomies it was investigated histologically, by a horizontal sectioning technique, how often the nipple and/or areola were involved in breast cancer. Such involvement was found in 35 cases (43.8%). In the same series the value of the clinical findings as to involvement of the nipple and/or areola was assessed. Only 6 of the 35 cases had shown clinical changes that could give rise to a suspicion of spread to the nipple and/or areola.

Breast↗
PubMed1979

Spread to the nipple and areola in carcinoma of the breast.

In 40 breasts with primary carcinoma, the nipple and areola were cut horizontally in order to investigate the frequency of intraductal and invasive cancer. In 20 of these breasts the nipple and/or areola were found to be involved at a depth of 1 cm (50%; 95% confidence limits: 33.8-66.2%). Eleven neoplasms were purely intraductal, eight intraductal as well as stromal, and only one purely stromal. By means of clinical or physical findings, it was not possible to select the breasts in which the nipple and/or areola were not involved. It is concluded that the general use of surgical methods preserving the nipple and areola in treating breast cancer leaves a focus of invasive or intraductal carcinoma in about half the patients. The implications of this are not known.

Breast↗
PubMed1979

TA and the dentist.

Explore the source record for details and available documents.

Dentist-Patient Relations↗