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Biomedical subjects

J A Andersen

Publications and source records attributed to J A Andersen.

At least 73 records · Page 4Linked to original sources
PubMed1988

Quality control of patho-anatomical diagnosis of carcinoma of the breast.

Three pathologists, especially interested in breast cancer, reexamined 379 random specimens of invasive breast cancer initially diagnosed at 27 pathological institutes; these were obtained from the computer register of the Danish Breast Cancer Cooperative Group (DBCG). The degree of variation between a) the primary diagnosis (the country as a whole) and each of the 3 pathologists and b) between the 3 pathologists mutually, has been studied with regard to the 2 main groups of carcinoma--infiltrating duct carcinoma (IDC) and infiltrating lobular carcinoma (ILC). The degree of variation was found to be similar between each of the 3 pathologists and the country as a whole, with a kappa value of approx. 0.3 for both types of carcinoma, and a considerably better interobserver variation between the 3 pathologists with a kappa value of approx. 0.7. The most important reason was that the 3 pathologists agreed on the occurrence of more than twice as many cases primarily diagnosed as ILC. A partial explanation is in fact that since the start of DBCG, reports have appeared of variants of ILC not previously known. The diagnosis of malignancy (carcinoma) was almost completely unambiguous.

Breast Neoplasms↗
PubMed1988

Breast cancer: risk of axillary recurrence in node-negative patients following partial dissection of the axilla.

The estimated probability of false negative nodal staging was analysed in breast cancer patients who had lower axillary dissection in conjunction with mastectomy and who were initially characterized as node negative. The series comprised 3128 consecutive female patients with invasive mammary carcinoma treated by surgery alone according to a nationwide DBCG protocol, 77-1a (Danish Breast Cancer Co-operative Group). The median number of removed lymph nodes was four, range 0-30. Median followup period was 6.5 years, quartiles 5.5 and 8.0 years. Ipsilateral axillary recurrences appeared in 178 patients (5.7%) during the followup period. The estimated 5-year probability for developing axillary relapse, calculated on the basis of lifetable analyses, was 19% in patients with no lymph nodes removed, 10% with 1-2 removed and negative nodes, 5% with 3-4, 3% with 5-10, and 3% with more than 10 removed and negative lymph nodes. No detectable increase in estimated probability could be traced in patients with five or more nodes removed during followup beyond 5 years, while in patients with less than five nodes removed the probability of axillary recurrence ascended continuously. The study also revealed a significantly decreased survival in groups of patients with less than five nodes removed and negative compared with groups of patients with five or more nodes removed. It is concluded that lower axillary dissection is associated with a certain risk of overlooking lymph nodes metastases, whereby the patients may be deprived of optimal adjuvant therapy. Misjudgment of the qualitative axillary nodal staging is modest, provided that at least five lower lymph nodes are removed.

Actuarial Analysis↗
PubMed1987

Complex dislocation of the metacarpophalangeal joint of the little finger.

Complex dislocation of the little finger metacarpophalangeal joint is very rare. In the English literature, we have found only ten published cases. The condition usually requires open reduction, and most authors advocate a dorsal incision. We report two additional cases, treated by the volar approach, which makes a direct access to the incarcerated structures possible.

Adult↗
PubMed1987

Breast cancer and atypia among young and middle-aged women: a study of 110 medicolegal autopsies.

In 110 consecutive, medicolegal autopsies of young and middle-aged women (range 20-54 years) the breasts were examined by an extensive histopathologic method and by correlative specimen radiography. Malignancy was found in 22 women (20%) of which only one was known to have had clinical invasive breast cancer (IBC). At autopsy 2 women had IBC (2%), the remaining in situ carcinoma (in situ BC) of microfocal type (18%), i.e. 15 (14%) intraductal carcinomas (DCIS), 4 (3%) lobular carcinoma in situ (LCIS) and one (1%) both DCIS and LCIS. Forty-five per cent of the women with malignancy had multicentric and 41% had bilateral lesions. Forty-five per cent of all histologically confirmed malignant lesions were identified by specimen radiography. Adenosis, benign epithelial hyperplasia, papilloma and duct ectasia were positively associated with malignancy. In addition malignancy was significantly more frequent among women aged more than 40 years, with late age at first full-term pregnancy, with alcohol abuse and with steatosis or cirrhosis of the liver. The results suggest that clinically occult in situ BC are frequent in young and middle-aged women.

Adult↗
PubMed1987

Gynecomastia. Immunohistochemical demonstration of estrogen receptors.

Immunohistochemical estrogen receptor (ER) analysis using a monoclonal ER antibody was performed on a total of 30 specimens from 26 patients with gynecomastia. Twenty-six specimens were ER-positive, 3 were ER-negative, and the analysis failed in one case. Immunohistochemical analysis proved more sensitive than biochemical ER analysis in a group of 20 patients, and in a group of 6 patients, the immunohistochemical analysis correlated well with in vitro hormonal sensitivity of the gynecomastic tissue. Semi-quantified ER content was inversely correlated with patient age. There was no relationship between ER content and either histopathologic features or hormonal status. In conclusion, this study demonstrates that the intracellular ER responsible for estrogenic stimulation is present in most gynecomastic tissue specimens, supporting the general assumption that estrogen can be one of the hormones responsible for the development of gynecomastia.

Adult↗
PubMed1987

Forefoot amputation in rheumatoid arthritis.

Five patients with long-standing rheumatoid arthritis underwent transmetatarsal amputation. Operative indications were severe pain on walking, marked deformity of the forefoot, and no effect of conservative treatment. After a median follow-up time of 7 (1-12) years, 4 patients had no pain, all patients could wear normal shoes, and the gait was significantly improved without imbalance.

Amputation, Surgical↗
PubMed1987

Chromosome changes of in situ carcinomas in the female breast.

Eight lesions of ductal carcinoma in situ (DCIS) and one case of benign radial scar were investigated cytogenetically and compared with invasive ductal carcinomas. DCIS was shown to be associated with chromosome changes different from those of invasive carcinomas as concern ploidy levels. All cases exclusively contained abnormal metaphases, also the specimen that was classified as a benign radial scar. No consistent chromosome changes were found. Chromosome no. 1 was most frequently involved in marker chromosome formation.

Breast Neoplasms↗
PubMed1985

Probability of false negative nodal staging in conjunction with partial axillary dissection in breast cancer.

There is a risk of overlooking lymph node metastases and thereby contributing to inaccurate nodal staging when performing partial axillary dissection in conjunction with total mastectomy in female breast cancer. The Danish Breast Cancer Cooperative Group (DBCG) analysed this risk in a prospective nation-wide adjuvant trial dealing with primary operable breast carcinoma. The series comprised 3114 patients, initially found to have lymph node negative axillae, followed for a median of 24 months (quartiles 12-40). It was found that the probability of early ipsilateral axillary relapse of cancer, estimated by means of the life table method, decreased with the number of nodes removed. After 2 years the recurrence rate was 12 per cent for patients with no lymph nodes removed, 7 per cent with one or two nodes removed and 2 per cent with three or more nodes removed. It is concluded that the risk of false negative nodal staging in conjunction with partial axillary dissection is modest, provided at least three lymph nodes are removed and found to be negative on histological examination.

Adult↗
PubMed1985

An autopsy study of radial scar in the female breast.

In a study of breasts from 83 consecutive, unselected female autopsies, 23 women (28%) were found to have radial scars. The lesion was multicentric in 67% and bilateral in 43%. The frequency of radial scar was significantly increased among women with fibrocystic disease (43%) compared to women without this lesion (17%). No difference in the frequency of radial scar was registered between women with primary breast malignancy and women with either normal breasts or benign breast abnormalities. No radial scar demonstrated transition to invasive or in situ carcinoma. No evidence was found of any association between radial scar and breast carcinoma.

Adult↗
PubMed1985

Gynecomasty: estrogen and androgen receptors. A clinical-pathological investigation.

The histology, estrogen (ER)- and androgen (AR)- receptor content, s-FSH, s-LH, s-17-beta-estradiol, U-17-ketosteroid and U-17-ketogenic steroid patterns were measured in a consecutive series of 20 patients operated on for gynecomasty. Two out of 22 specimens were ER-positive, and 4 out of 22 were AR-positive. No relationship was demonstrated between the histopathologic features, ie. active-intermediate-inactive gynecomasty, and the steroid receptor content in the present limited number of cases. In addition, there was no marked relationship between the histopathologic features and the hormone values.

17-Hydroxycorticosteroids↗
PubMed1984

Radial scar in the female breast. A long-term follow-up study of 32 cases.

In a retrospective histologic study of 1862 benign breast tissue specimens, 32 cases were found to have radial scar. The radial scar was multicentric in 44%, and found in breasts with fibrocystic disease and/or duct ectasia. During a follow-up period of 19.5 years (range, 15-24 years), one patient developed breast cancer compared with an expected rate of 0.94. Therefore, local excision of radial scar without further follow-up is sufficient.

Adenofibroma↗