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Biomedical subjects

I Werner

Publications and source records attributed to I Werner.

At least 73 records · Page 4Linked to original sources

Stroke before fifty. Experiences from a five-year study.

Thirty-seven patients below the age of 50, with an acute first-time cerebrovascular lesion have been studied. Some form of predisposing factor was present in nearly all cases. There was a remarkably high incidence of cardiovascular and cerebrovascular disease among the parents of the stroke victims. Only 50% of the patients with hypertension known prior to the stroke had received adequate treatment. There were six females on oral contraceptives. The immediate mortality, i.e. within one month, was 35% essentially caused by a very high initial mortality among patients with cerebral haemorrhage. The patients were checked after 30 months. At this time, 16 patients were still alive and 11 able to perform some sort of work. Among the survivors there was a high incidence of diabetes and impaired glucose metabolism, to judge from intravenous glucose tolerance tests. The chances of survival and vocational rehabilitation seem to be fairly good, compared with higher age groups, thus urgently calling upon the resources of the community for active therapeutic measures and training. Individuals with hypertension and impaired glucose tolerance, with heredity for vascular disease and diabetes seem to be especially at risk for early stroke. Health surveys should be directed to tracing these subjects early.

Age Factors↗

Normocalcemic hyperparathyroidism, kidney stones, and idiopathic hypercalciuria.

Eighty-four patients with recurrent kidney stones, serum calcium levels in the upper normal quartile, and most of whom with hypercalciuria had their parathyroids surgically explored. Parathyroid adenomata were found in 19 patients, hyperplasia in 39, and normal parathyroids in 26. Postoperatively there was a significant fall in serum calcium and urinary calcium excretion in all three groups. At clinical follow-up 2 to 5 years postoperatively there was no case of kidney stone recurrence among the adenoma patients. In the hyerplasia group there were recurrences tn 25 percent. The corresponding figure for the patients with normal parathyroids was 48 percent. The concept of normocalcemic primary hyperparathyroidism and the relationship between this syndrome and idiopathic hypercalciuria are discussed. Some prinicpal therapeutic measures are recommended.

Adult↗