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Biomedical subjects

I Weiner

Publications and source records attributed to I Weiner.

83 records · Page 5Linked to original sources
PubMed1980

Retroperitoneal fibrosis.

Retroperitoneal fibrosis may be classified as either primary or idiopathic, probably of autoimmune origin or secondary to a malignant process. Both classes are usually presented identically, and it is the responsibility of the physician to exclude a malignant process. The disease should be especially suspected in patients with signs and symptoms of irritation of the retroperitoneal space, such as pain in the lower part of the back or in the flank, a distribution of pain down the legs and, at times, a positive Patrick's sign. Gray scale ultrasonography and computerized axial tomography may now be used to help in the diagnosis of this entity and also in the follow-up management. Operation is recommended for diagnosis and correction of any ureteral impairment. Steroids may be an invaluable aid for the treatment of this disease.

Adult↗
PubMed1969

Albumin synthesis in cirrhotic subjects with ascites studied with carbonate-14C.

The synthesis of serum albumin was measured in 19 patients with cirrhosis of the liver and ascites. Carbonate-(14)C was used to label the guanido carbon of arginine in albumin.18 of the patients had the diagnosis of cirrhosis confirmed by biopsy and/or by the presence of esophageal varices. Seven patients with albumin synthesis rates of 42-105 mg/kg per day demonstrated the lowest serum cholesterol esters and highest serum glutamic oxalacetic transaminase (SGOT) levels, while the seven patients whose albumin synthesis rates ranged from 203-378 mg/kg per day, had significantly higher cholesterol ester levels and significantly lower values for SGOT. The serum albumin levels were equally depressed in all patients. In patients with cirrhosis and ascites albumin production was found to be normal or elevated in seven of the 19 subjects, and only markedly depressed in seven patients, in spite of the fact that the serum albumin level was depressed in all patients.

Adult↗
PubMedDate not supplied

Gender- and age-dependent differences in latent inhibition following pre-weaning non-handling: implications for a neurodevelopmental animal model of schizophrenia.

Latent inhibition (LI) refers to retarded conditioning to a stimulus as a consequence of its prior nonreinforced pre-exposure, and is considered to index the capacity of an organism to ignore irrelevant stimuli. LI disruption has received increasing attention as an animal model of the widely described attentional deficit of schizophrenia, consisting of an inability to ignore irrelevant stimuli. The present experiments investigated the effects of infantile manipulations on the development of LI. Male and female rats handled or nonhandled in infancy (days 1-22), were tested at 3 and 16 months. Young handled animals had lower emotional reactivity than nonhandled, and this difference persisted in females at 16 months. At 3 months. LI, poorer conditioning of stimulus pre-exposed as compared to nonpre-exposed rats, was obtained in handled and nonhandled females, as well as in handled males, but was absent in nonhandled males. This pattern changed at 16 months: both nonhandled males and females failed to show LI. These gender- and age-dependent effects of pre-weaning manipulations on LI loss may provide an animal parallel to the susceptibility of young adult males to schizophrenia and the attenuation of gender differences in long-term outcome schizophrenia.

Aging↗