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Biomedical subjects

I W Scopp

Publications and source records attributed to I W Scopp.

At least 19 recordsLinked to original sources
PubMed1982

Periodontal healing following open debridement flap procedures. I. Clinical assessment of soft tissue and osseous repair.

The healing response of the periodontium was evaluated after periodontal flap and debridement procedures in patients with different levels of postsurgical plaque control. Thirty-one sites in 19 patients were included. Measurements were performed from a fixed reference point presurgically and before reentry surgery. All reentries were performed 24 to 28 weeks after surgery. Surgery consisted of elevating an inverse bevel mucoperiosteal flap, debriding root accretions and osseous defects, penetrating into the marrow, and suturing with interrupted sutures at or near the presurgical level. All patients were recalled at least once every 4 weeks after surgery fof professional maintenance. The number of postsurgical maintenance visits and plaque scores (NPI) before reentry were recorded for each surgical site. Average pocket depth at the 31 sites was 7.4 mm initially and 4.1 mm at the time of reentry. This reduction in pocket depth consisted of gingival recession, which averaged 2.0 mm, and a gain in attachment level, which averaged 1.4 mm. At no site was there a loss in attachment level. Average osseous depth of the 31 defects was 3.7 mm presurgically and 1.7 mm at reentry. In addition, there was an average crestal resorption of 0.8 mm and an average osseous fill of 1.2 mm. A significant positive correlation (P less than 0.001) was found between gain in attachment, osseous fill and number of postsurgical maintenance visits. A significant negative correlation was found between the amount of plaque (NPI) at the study site and both gain in soft tissue attachment and osseous fill. Multiple measurements at various points within several osseous defects revealed that osseous remodeling and fill varied significantly at different locations within the same defect.

Adult↗
PubMed1982

Human clinical and histologic responses to Durapatite implants in intraosseous lesions. Case reports.

The healing response following implantation of a nonresorbable ceramic (durapatite) into human periodontal osseous defects was evaluated clinically and histologically. Four tooth-containing blocks were obtained from four patients who had received durapatite implants in osseous defects, each exceeding 4 mm in depth. Each patient was seen for 5 to 13 postsurgical maintenance visits. Teeth in block section were removed between 8 weeks and 8 months postgraft surgery. Clinical evaluation of the repair process demonstrated that pocket depth decreased in all four cases. Histological evaluation of the repair process showed no indication of new periodontal attachment, osteogenesis or cementogenesis, in the host tissues adjacent to the graft particles. Pocket closure appeared to occur by means of a long junctional epithelium and connective tissue adhesions. There was minimal or no evidence of inflammation in all sections associated with the implant. The graft material therefore acted as a biocompatible foreign body within the gingival tissue.

Adult↗
PubMed1980

Tetracycline: a clinical study to determine its effectiveness as long-term adjuvant.

A random double blind crossover study of patients on the effects of tetracycline therapy over a 3-month period revealed that there were no significant differences between the placebo group and tetracycline-treated groups in relation to (1) Gingival Index, (2) Debris Index and (3) Papillary Bleeding. A marked improvement in the Gingival Index occurred after 3 months of treatment in each group resulting from curettage and home care. Papillary bleeding was significantly reduced after 3 months of treatment in the tetracycline group and similar trends were observed in the placebo group. The Debris Index in both experimental and placebo groups showed no significant change after treatment for 3 months. The data suggest that tetracycline therapy does not appreciably after either the Gingival Index, Debris Index, or the Papillary Bleeding Index over a 3-month period.

Clinical Trials as Topic↗
PubMed1980

Salivary composition and calculus formation in patients undergoing hemodialysis.

The purpose of this report is to provide further information regarding oral changes in patients with chronic renal disease who are undergoing hemodialysis. Quantitative changes in salivary flow rate and alterations in the composition of stimulated and unstimulated sliva were studied along with the rate of formation of supragingival calculus. Results revealed a lower salivary flow rate and increased salivary urea concentration in the dialysis group. Dialysis patients also formed more heavy calculus.

Adult↗
PubMed1979

Combined orthodontic-periodontal treatment of an infrabony defect. A case report.

A case presentation involving the combined orthodontic-periodontic treatment of a distally inclined mandibular left central incisor with a mesial infrabony defect is reported. Treatment was performed in three phases: (a) the tooth was moved upright (b) periodontal surgery with osseous grafting of the infrabony defect was then performed; and (c) the operative site was reentered 5 months later. The patient was followed and soft and hard tissue changes were documented for 12 months from time of initiation of treatment.

Alveolar Process↗
PubMed1978

Oxidative phosphorylation in rat oral mucosal mitochondria.

Oral mucosal mitochondria were isolated and characterized morphologically by electron microscopy. Polarographic measurements were made of respiration and oxidative phosphorylation in the mitochondrial preparations. ADP:O ratios approaching or slightly exceeding the theoretical maxima and stabilized respiratory control ratios were achieved with malate + glutamate, succinate and ascorbate-N,N,N1N1 tetramethyl-p-phenylenediamine (TMPD) as substrates. Inhibition by rotenone, antimycin A, azide, and cyanide established the classical electron transport chain as the major pathway of mitochondrial respiration. Respiration of the oral mucosal mitochondria was stimulated by DNP in the presence of succinate. DNP-stimulated respiration exceeded that observed in the presence of ADP plus Pi and increasing the concentration of DNP progressively inhibited respiration.

Acid Phosphatase↗
PubMed1977

Oral manifestations of secondary hyperparathyroidism related to long-term hemodialysis therapy.

Patients on long-term hemodialysis therapy may develop secondary hyperparathyroidism with oral symptoms. As the life expectancy of the dialysis patient increases, the dentist is seeing these manifestations with increasing frequency. A review of the subject is presented along with a case illustrating dramatic roentgenographic changes in a patient who was placed on hemodialysis when the technique was in its infancy.

Adult↗