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Biomedical subjects

I V Vasilenko

Publications and source records attributed to I V Vasilenko.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[Modifications of gastric mucosa in diffuse and intestinal cancer].

The study was made of 29 intestinal type gastric carcinomas, 37 diffuse type gastric carcinomas and stomach mucosa (SM). Both carcinomas slightly differed by frequency of the fundal glands atrophy. Intestinal type was characterized by a higher frequency of antral glands atrophy, intestinal metaplasia, particularly of colon type. Intestinal cell differentiation was about the same in both types. Hyperplasia of lining and endocrine cells in the fundal part of the mucosa was more frequent and neuroendocrine differentiation was more pronounced in diffuse stomach carcinoma. It is suggested that environmental impacts including helicobacter pylori result in proliferation of the epithelium, intestinal metaplasia, dysplasia and carcinoma of the intestinal type. Diffuse carcinoma is associated with proliferation of glandular epithelium (parietal, endocrine, cervical) due to genetic factors, hypergastrinemia caused by fundal gland atrophy, alkalization of the mucosa due to Helicobacter pylori infection.

Adenocarcinoma↗
PubMedDate not supplied

[Pathogenetic mechanisms of optic nerve lesions in acute vascular optic neuropathies].

The authors analyze the findings of histomorphologic and immunomorphologic studies of 20 cadaver optic nerves from subjects with a history of acute vascular optic neuropathies due to atherosclerosis, eventuating in optic nerve atrophy: 13 atrophic optic nerves and 7 pair nerves from clinically normal eyes of the same patients were examined. The blood sera of 30 patients suffering from acute vascular optic neuropathies were tested. Noteworthy that vascular optic neuropathy associated with atherosclerosis is a bilateral process. Vascular insufficiency due to sclerotic changes in vessels of various diameters undoubtedly contributes to the pathogenesis of the optic nerve impairments in the involved and clinically healthy eyes. The developing immune status disorders and autoimmune processes also contribute to the genesis of sclerotic shifts in the vessels and optic nerve atrophy in both eyes.

Acute Disease↗
PubMedDate not supplied

[A comparison of the differentiation of tumor cells and of the epithelium of the gastric mucosa in cancer].

The correlation between differentiation of tumor cells in different directions (toward the foveolate epithelium or glandular epithelium in stomach, or small and large intestine epithelium, or endocrine cells) and the state of gastric mucosa (differentiation of its cells in direction of foveolate epithelium or glandular epithelium (hypoplasia of corresponding epithelium), or appearance of focals of metaplasia in small or large intestines, or pronounced hyperplasia of endocrine cells) was revealed in most cases of gastric cancer. The other of the disease did not reveal such correlation.

Adenocarcinoma↗
PubMedDate not supplied

[Argyrophilic proteins in the nucleolar organizer in the differential diagnosis of cervical dysplasias and cancer].

Prospects of using the nucleolar organizer region (NOR) identification by silver nitrate for the diagnosis of dysplasias and cervical cancer were studied. Four groups of patients (22 cases) have been examined: group 1 (7 cases)--unchanged endocervical epithelium, group 2 (6 cases)--dysplasia of cervical epithelium of degree II-III, group 3 (3 cases)--carcinoma in situ, group 4 (6 cases)--invasive squamous cell nonkeratinizing carcinoma. The investigation showed that there are reliable differences in the quantity of silver granules per nucleus and also of NOR index between normal ectocervical epithelium and dysplasia, normal ectocervical epithelium and cancer, dysplasia and cervical cancer. The data obtained suggest that NOR argyrophilia may be a diagnostic marker of the tumor malignancy degree.

Carcinoma in Situ↗
PubMedDate not supplied

[The clinico-morphological characteristics of glomerulonephritis in infectious endocarditis].

Clinicomorphological characteristics of glomerulonephritis in infectious endocarditis (IEGN) were studied in 62 patients (with samples of autopsy material being used in 52 instances). IEGN presents with dissaminated and focal proliferative alterations involving extracapillary and/or tubulointerstitial components, and is characterized by a broad variability of indices for proteinuria, hematuria and cylindruria. In diffuse prolipherative glomerulonephritis the degree of proteinuria and cylindruria appear to be significantly higher than in focal segmental proliferative glomerulonephritis, as is the incidence rate of development of renal insufficiency and its gravity.

Adolescent↗
PubMedDate not supplied

[The clinico-morphological characteristics and treatment of minimal-change glomerulonephritis and focal-segmental glomerulosclerosis-hyalinosis].

Clinical and morphological features were analysed of the morbid condition in 46 patients with glomerulonephritis presenting with minimal alterations (GNMA) and 12 those with focal-and-segmental glomerulosclerosis-hyalinosis (FSGH), of whom there were twenty nine males and twenty nine females ranging between 15 to 54 years. In all cases morphologic diagnosis was established on the basis of vital histologic investigation of renal tissue. Immediate results were assessed of glucocorticoid and cytostatic therapy instituted at different stages of the condition. High effectiveness was documented of glucocorticosteroids in GNMA patients along with the ability of cyclophosphamide to significantly decrease the frequency of exacerbations and make such patients free from steroid dependency. GSGH patients derived no benefit from glucocorticoids while cyclophosphamide was associated with complete GH patients azathioprine therapy had no positive effect on the course of the illness.

Adolescent↗