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Biomedical subjects

I Tomov

Publications and source records attributed to I Tomov.

At least 19 recordsLinked to original sources
PubMed1979

[Echocardiographic changes in tricuspid insufficiency].

The following echocardiographic changes were found in 42 patients with catheterization data for tricuspid insufficiency: all echocardiographic dimensions of the right ventricle and right auricle are considerably increased; the interventricular septum reveals paradoxical movements in 38 per cent of the cases; the tricuspid echogram shows unspecific changes in the speed and amplitude parameters of the anterior tricuspid cusp--increased speed (D--E) and amplitude (C--E) of opening, increased speed of backward movement in an early diastole (E-F), increased speed of closing (A--C),increased duration of the final diastolic intervals A--C and Q--C, the difference between the Q--C interval duration of the tricuspidal valve and Q--C interval of the mitral echogram is pathologically increased, the ratio between the speed of E--F segment of the tricuspid valve and E--F segment of the mitral valve is also increased. The diagnostic sensitivity of those changes of the tricuspid echogram is about 75 per cent. EchoC-diagnosis of the tricuspid insufficiency is based on the combination of considerably increased EchoC-dimensions of the right ventricle and the right auricle, paradoxical movements of the interventricular septum and the changes of the speed and amplitude parameters of the tricuspid echogram.

Adolescent↗
PubMed1979

[Echocardiographic indices of the pumping and contractile functions of the left ventricle and left ventricular cardiac insufficiency].

EchoC-indices for the left ventricle function and the degree of left ventricular insufficiency are confronted in 148 patients with various degree of left ventricular insufficiency determined by clinical and instrumental non-invasive examination, right and/or left heart catheterization and the method of dye dilution. It was established that in the differentiation of the initial left ventricular insufficiency, EchoC-indices of the pump and contractility function of the left ventricle have a diagnostic sensitivity of 94 per cent and give a relatively low false positive (12%) and false negative results (6%). EchoC-indices, which are with the highest diagnostic sensitivity in the determination of the initial left-ventricular insufficiency, are the telediastolic size and left ventricular volume; the fraction of shortening, average rate of contraction of the circumferential fibrils and the fraction of forcing out.

Adult↗
PubMed1979

[Echocardiographic indices of the pumping and contractile functions of the left ventricle and the hemodynamic data obtained from left and/or right cardiac catheterization].

A juxtaposition of the EchoC-indices for the pump and contraction function of left ventricle and the hemodynamic data obtained with right and left cardiac catheterization was carried out in 95 patients with different myocardial and valvular heart diseases. The following EchoC-indices were determined for the assessment of the left-ventricle function -- telediastolic dimension and volume of left ventricle, stroke and minute heart volume, fraction of shortening (FS), average contraction speed of circumferential fibres (CCF), fraction of expulsion (FE), left auricle dimension. A considerable correlation was found among the EchoC-indices for pump and contraction function of left ventricle and the final diastolic left ventricle pressure and the average left auricle pressure. In heart patients with a normal final diastolic pressure in left ventricle and average left auricle pressure, pulmonary capillaries (PC) resp., the average values of all functional EchoC-indices are normal. With an elevated final diastolic pressure in left ventricle, diminished values of dP/dt max and elevated mean pressure in left auricle, the pulmonary capillaries resp., the values of all EchoC-indices for the pump and contraction left ventricle function are pathological -- enlarged telediastolic dimension and left ventricle volume, enlarged dimension of left ventricle, reduced values of FS, CCF, FE, SV and MV. EchoC-functional indices properly differentiate the pathological from the normal hemodynamics of left ventricle. determined by catheterization in 86 per cent of the cases. The false positive and false negative results are obtained in 14 per cent of the cases.

Cardiac Catheterization↗
PubMed1979

[Echocardiographic evaluation of left ventricular function in mitral valve prolapse].

Echocardiographic assessment of left ventricle functions was performed in 52 cases with idiopathic prolapse of mitral valve, confirmed on the base of the simultaneous presence of the well known auscultatory, phonocardiographic and echocardiographic criteria. Mitral prolapse was established not to be a homogenous group as regards left ventricle function. The majority of the cases (80.7%) had normal EchoC-indices for the pump and total and local contraction function of left ventricle. The cases without (25%) or with light stage (55.7%) mitral regurgitation are included here. In the presence of hemodynamic significant mitral insufficiency -- 13.5% of the cases. EchoC-manifestations for volume left-ventricle loading were found -- enlarged telediastolic dimension and volume of the left ventricle cavity, light hypertrophy and hypercontractility of the interventricular septum and/or the unattached posterior wall of left ventricle, enlarged left ventricle, increased velocity of EF-segment of the anterior mitral cusp. As a rule, a moderate mitral regurgitation is concerned in those cases. In a small number of cases with mitral prolapse (5.8%) EchoC-manifestations for a light to moderate pump and general and/or local contraction function of left ventricle was established without clinical data for a stasis in left ventricle cardiac insufficiency. Grounds exist to admit that in the last cases, a rather not severe local or more diffuse lesion of the left ventricle myocardium is concerned, its relationship with the mitral valve prolapse remaining obscure.

Adult↗
PubMed1979

[Echocardiographic evaluation of left ventricular function in ischemic heart disease (IHD)].

A comparison was performed between the echocardiographic (EchoC) indices for the pump and contraction function of left ventricle and the stage of left-ventricle insufficiency, determined according to clinical criteria of 82 patients with ischemic heart disease (IHD)--old myocardial infarction and (or stable angina pectoris without left-ventricle infarction and for stable angina pectoris without left-ventricle aneurysm. With IHD, regardless of the considerable asynergy of left ventricle, some of the functional EchoC-indices were established to preserve their diagnostic values and definitely to differentiate the majority of the cases with, from those without, cardiac insufficiency, objectivizing the determination of initial left-ventricle insufficiency. The most significant diagnostic value of EchoC-assessment of left-ventricle function in IHD has the following complex of EchoC-indices: diastolic extent, left ventricle index resp, expulsion fraction (EF), shortening fraction (FS), average velocity of circumferential fibres (VCF), distance between point E of mitral echogram and interventricular septum (S-E distance), telediastolic interval A-C of mitral echogram and extent, index of left auricle, resp.

Adult↗
PubMed1978

[Echocardiographic changes in a defect of the interatrial septum].

The echocardiographic changes in 43 patients with defects of the interrauricular septum, confirmed by catherization were studied. In 42 out of 43 (98%) cases considerably enlarged dimensions of the right ventricle and right auricle were found. Paradoxical movement of the interventricular septum was found in 39 out of 43 (91%) cases. The paradoxical movement of the interventricular septum is characterized by a considerable amplitude towards the right venticle. The tricupid valve shows an increased amplitude of opening (CE), enlarged A wave, accelerated speed of opening (OE segment), accelerated speed of backward movement in early diastole (EG segment) and decelerated closing (AC segment). The enlarged dimensions of the right ventricle, the paradoxical movements of interventricular septum and the changes of the tricupid valve are a characteristic EchoC-triad, never absent in the hemodynamically significant volume loading of right ventricle, originating from the left-right shunt at an auricle level.

Adult↗
PubMed1978

[Clinical trial of the preparation clofazolin used intravenously].

The authors studied the hypotensive effect of the Bulgarian preparation Chlophazolin in ampoules of 0,15 mg, administered i. v. The study covered 50 patients, 44 of them with hypertonic disease II and III stage and the rest (6)--with renal and renovasal hypertension. The i. v. administration of chlophazolin was established to have a marked hypotensive effect and be expedient for the treatment of hypertonic crises and hypertension with high values. In a dose of 0,15 mg i. v. the preparation leads to a sharp decrease in the first 20 min, whereas during the following hours it is kept to lower values: systolic pressure-an average decrease of 30-40 mm Hb in a lying position, to 45-50 mm Hg in an erect position; the diastolic pressure-an average decrease of 10-15 mm Hg in a lying position to 20-25 mm Hg in an erect position. The hypotensive effect is better manifested in higher initial values of the pressure. It lasts approximately more than 13 hours but in 1/5 of the patients, with higher values of blood pressure, its effect is exhausted within 6-8 hours. Side effects of the preparation were registered in 26 per cent of the cases; orthostatic disturbances, sleepiness, dryness of the mouth, nausea. I. v. administration of chlopazolin does not change the excretion of urea and creatinine, diuresis and serum levels of sodium, potassium and chlorine.

Adolescent↗
PubMed1978

[Echocardiographic (EchoC) dimensions of the right cavities of the heart in right ventricular insufficiency].

Seven dimensions of the right ventricle at different levels and one dimension of the right auricle at the tricuspidal valve level were determined in 414 patients with cardiac ailments without volume loading. The data obtained are confronted with the hemodynamics of the right ventricle determined via clinical investigations, right cardiac catheterization and the method of dye dilution. A considerable correlation exists between the size of the EchoC-dimensions of the right ventricle and right auricle and the values of the final diastolic pressure in the right ventricle and the mean pressure in the right auricle, being a precondition for the determination of the right ventricle function via echocardiography. Enlargement of all EchoC-dimensions of the right ventricle and right auricle is present in right ventricle insufficiency. The echocardiography dimensions of the right ventricle and right auricle show a high sensitivity (91%) in the determination of initial right-ventricle insufficiency, presenting a relatively low false positive results (13%).

Adolescent↗
PubMed1978

[Echocardiographic dimensions of the right cavities of the heart in systolic overload of the right ventricle].

The echocardiographic dimensions of the right ventricle and right auricle and the systolic pressure in the right ventricle were compared in 102 patients with different heart diseases. The data obtained are compared with the same echocardiographic parameters in 79 healthy subjects and 43 patients with volume loading of the right ventricle, a result of intraauricular defect, confirmed by cahteterization. The dchocardiographic dimensions of both right ventricle and auricle were proved not to be enlarged with the systolic loading of the right ventricle, when the right-ventricle function is compensated. Echocardiographic dimensions of the right heart cavities are enlarged with systolic loading of the right ventricle when the continuous diastolic pressure in the right ventricle raises and with the presence of clinical data for a right-ventricular cardiac insufficiency. The echocardiographic dimensions of the right ventricle and right auricle are considerably enlarged with the volume loading of the right ventricle, regardless the absence of right-ventricular cardiac insufficiency. The echocardiography provides a possibility of determining the type of right-ventricle loading by a non-invasive method and of determining the presence of right-ventricular insufficuency.

Adult↗