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Biomedical subjects

I Strempel

Publications and source records attributed to I Strempel.

44 records · Page 3Linked to original sources
PubMed1977

[Isolated orbitobulbar sarcoidosis].

Communication about a rare form of Boeck's disease. A primary orbital sarcoidosis is described with probable optic nerve involvement and later intraocular invasion in the form of a single candle spot-shaped chorioretinitis. No other clinically noticeable extensions of this disease could be noticed. Clinical and histological findings were described and discussed, in view to the existing literature on that subject.

Chorioretinitis↗
PubMedDate not supplied

Topical allopurinol or corticosteroids and acetylcysteine in the early treatment of experimental corneal alkali burns: a pilot study.

PURPOSE: To investigate the effect of topical allopurinol on experimental corneal burns and to compare this to established treatment modalities such as topical prednisolone and acetylcysteine. METHODS: Twenty Wistar rats were randomly assigned to four groups (n=5 each). The groups were controls (normal saline), allopurinol 0.4% eye drops, prednisolone acetate 1% eye drops and acetylcysteine 8% eyedrops. Corneal burn was induced using a 3 mm paper disc soaked in 1N NaOH for 60 seconds. Drops were instilled 6 times per day. In addition, one drop/day ofloxacine was given to prevent secondary infections. Eyes were enucleated 50 hours later and fixed in 4.5% formaldehyde. Three histological levels of each globe were stained with hematoxylin-eosin and examined by two independent masked investigators using a 0 to 4+ inflammatory score. All pair-wise multiple comparison procedures (Student-Newman-Keuls method) were applied for statistical work-up. RESULTS: All three substances significantly reduced the number of histologically visible inflammatory cells compared to the control group (p<0.05). CONCLUSIONS: In the present study, topical allopurinol was as effective as established drugs, namely steroids and acetylcysteine, in the early treatment of experimental alkali corneal burns.

Acetylcysteine↗
PubMedDate not supplied

[Retinal detachment and sarcoidosis].

A 27 year old patient with histologically proven conjunctival sarcoidosis developed a posterior uveitis with retinal giant tear and inversion of retina. The patient was treated systemically with steroids and the retinal detachment healed by usual operation, visual acuity 6/10.

Adult↗