[Free and bound 8-methoxypsoralen levels in 24-hour urine of psoriasis patients].
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Biomedical subjects
Publications and source records attributed to I Steiner.
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A group of 52 patients was studied with a view to defining the characteristic features of aortic valve stenosis with calcification. There is no uniform aetiopathogenesis to explain the condition. 3 basic types could be distinguished--post-rheumatic, senile, and due to congenital malformation of the valve; all were represented about equally.
Serum levels of 8-methoxypsoralen (8-MOP) were determined 2 hours after oral administration and found to vary considerably among psoriatic patients. There was no definite correlation between the 8-MOP serum level, the dose of 8-MOP/kg body weight ingested, and the minimal phototoxic UVA dose.
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Cardiomyopathies have been characterized as diseases of the heart muscle of unknown cause. The dilated type [idiopathic cardiomegaly] cannot be regarded as a separate entity, but a uniform final result of myocardial damage due to various factors. Hypertrophic cardiomyopathy [asymmetrical hypertrophy of septum] probably represents a genetically conditioned disease with characteristic clinical and pathological features.
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A series of 8 patients serve to demonstrate an ill-recognized entity, viz. the aneurysm of the oval fossa. The factors primarily responsible for the development of the aneurysm include a connective-tissue disturbance in the interatrial septum and an alteration of the pressure ratio between the atria. The possible clinical significance has been stressed.
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The hearts of 14 patients dying early after replacement of a calcified aortic or mitral valve were examined for the presence of calcific coronary emboli. The incidence of embolization as shown by x-ray film was 92-9 per cent. The number of emboli in individual cases ranged from 4 to 119. Replacement of an aortic valve was associated with a more severe embolization than replacement of a mitral valve. Th mechanisms of calcific embolization are discussed and preventive surgical measures suggested.
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