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Biomedical subjects

I Sauer

Publications and source records attributed to I Sauer.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Human biological age].

By biological age is understood that state of the organism, with the inclusion of both physical and psychic parameters, which has been reached at a certain point of the chronological age. Experiments are reported which have been conducted in an attempt to measure the biological age of human beings by the aid of batteries of tests. So far, more than 1000 subjects have been examined, and they include both "normal subjects" and groups of patients showing such risk factors as overweight, hypertension, and diabetes mellitus. The motivation for such studies is the desire to satisfy practical needs. To tackle this problem it is necessary that investigators representing the various disciplines of gerontology should work closely together.

Aged↗
PubMed1981

[Electrocardiographic studies and cardiovascular radiographic findings in the aged].

Humans far advanced in years represent, in many respects, a positive selection of people showing particularly favorable adaptation to life circumstances. Correlated with the behavior of blood pressure were not only electrocardiographic results but cardiovascular x-ray results as well. Pathological ECG changes which are not affected by a specific therapy are entirely consistent with old age, with pronounced ECG changes accompanied by a marked variation in hemodynamics having not been observed in the aged in the sense of a positive selection. The aged, despite a large number of subjects showing development of particular conditions, did not generally include R1 patients with strain on both the left and right heart. On an average, the width of the aorta was not seen to increase further in the aged. Also, hypertension had no effect upon the width of the aorta in humans of advanced age. There was no evidence for an increase in the incidence of aortic sclerosis in the aged.

Adult↗
PubMed1980

[Longitudinal study of uric acid changes in a constant group from 1968-78].

From 1968 to 1978 in 195 test persons (53 males, 142 females) the longitudinal behaviour of the serum uric acid was examined by regular estimation. Independent on age, sex and body weight the concentration of uric acid significantly increased in the course of 10 years. As causes are discussed influences of nutrition, problems of physical and mental activity, therapeutic measures and medicaments as well as hormonal change. Change of the relative weight and level of uric acid did not correlate together. Developmental tendency of serum cholesterol and uric acid showed a negative correlation in younger men and a positive one in older men.

Adult↗
PubMed1980

[Cardiac x-ray findings and vascular calcification in arterial obstructive disease in the pelvic and leg region. II].

In 117 patients with arterial obstructive disease in the region of pelvis and leg compared with test persons with healthy vessels the percentage of the deformation of the heart according to the classification after Richter was significantly higher for the left-side prevailing bilaterally loaded heart as well as for the left-ventricularly loaded heart. No differences could be ascertained between hypertonic and normotonic patients with ill vessels. In the patients compared with the clinically healthy test persons we registered surface-kymographically and electrokymographically more frequently a pathological marginal movement of the heart as a reference to a myocardial dysfunction. The distinct pathological surface-kymographical and electrokymographical findings on the heart correlated with the electrocardiographical findings. The data got on the heart confirmed the indication of a cardial basal therapy existing in most cases in older patients with vascular diseases. The slight diameter of the thoracic aorta as well as the restriction of the surface-kymographically provable amplitude of the movement in the region of the arc may, compared with the test persons with healthy vessels, refer to a disturbed wind kessel function of the aorta, they let us think of a primary rigidity of the wall. On the basis of the present results of examinations the sum of simply to be established X-ray findings--form of the heart, measure of the aorta, state of sclerosis, surface-kymographical findings at the heart and the aorta--may characterize an advanced vascular disease.

Angiography↗
PubMed1980

[Cardiac findings and vascular calcification in arteriosclerotic obstructive disease in the pelvis and leg region. I].

In 117 patients with angiographically ascertained arteriosclerotic obstructive disease in the region of pelvis and leg the smoking of cigarettes in a high degree confirmed itself as atherogenic factor of risk. The rate of hypertension of patients with vascular disease was increased in comparison with the average population. In contrast to a control group of test persons who after clinical angiological examination did not give a clue to a vascular disease the patients with vascular diseases shows a significantly higher percentage of radiologically visible calcifications in the region of the abdominal aorta, the iliacal and the peripheral arteries of the legs. The calcification of the vessels were generalized in 85%. Apart from the calcification of the abdominal aorta the sclerosis was visible above all in the vascular are switched after the obstruction. There were no differences between normotonic and hypertonic patients with vascular diseases concerning the state of sclerosis. Clear correlations between the proof of sclerosations of the vessels and the apparative angiologically measurable narrowing of the vascular system are not known. Nevertheless in our opinion the calcification of the arteries of the legs in younger patients may be regarded as a reference to a disturbance of the arterial blood supply which must be clarified. The densitometrically established content of calcium salt in the calcaneus showed a dependance on the formation of collaterals and the state of sclerosis in the corresponding type of obstruction and may give a quantitative measure for the degree of severity of an ischaemic osteoporosis.

Age Factors↗
PubMed1980

[10 years - investigations of lipid-metabolism-parameters in the longitudinal study of Leipzig (author's transl)].

As part of the longitudinal gerontological study conducted in Leipzig, cholesterol and the fatty acid spectrum in the serum were determined (by gas chromatography) in 158 cases (46 men, 112 women) at intervals between 2 and 4 years over the period from 1968 to 1978. During the 10-year period the statistical values showed a definite increase in the percentage of cholesterol and linoleic acid. As a result of the significant decrease in the palmitic acid values, the saturated fatty acid percentages as a whole dropped despite an increase in stearic acid. The general trend was toward the elimination of differences between men and women and overweight persons and those with normal weights. There were definite correlations between a reduction in relative weight and a drop or reduced increase of cholesterol on the one hand an increase in linoleic acid on the other. This is most probably due to the fat-reduced and -modified diet to which especially the older test persons changes over during the 10-year period. This diet contained many polyene fatty acids. The changeover can therefore be suspected to lead to antiatherogenic fatty acid constellations in the serum.

Adult↗
PubMed1980

[Serum uric acid - the longitudinal behavior and age (author's transl)].

The longitudinal behavior of serum uric acid was studied by regular determinations made on a total of 195 subjects (of whom 53 were males and 142, females) between 1968 and 1978. The concentration of uric acid showed a significant increase within ten years irrespective of age, sex, and body weight. Nutritional influences, problems of physical and mental activity, therapeutical measures and agents, as well as hormonal alteration are discussed as possible cause thereof. There were no correlation between change in relative weight and uric acid level. Serum cholesterol and uric acid trends showed negative correlations in young men and positive correlations in older men.

Adult↗
PubMed1978

[Cardiovascular radiography, changes in the thoracic aorta, ECG and clinical parameters in hypertension. 2. Changes in the thoracic aorta in hypertension].

In 142 hypertensives and a control group of 230 normotensives the measure of the aorta after Kreuzfuchs was estimated. In the two groups a significant increase of the width of the aorta was found with growing age. Whilst the width of the aorta concerning the degree of severity I of hypertension on an average were slightly below those of normotensives, they were increased in the degrees of severity II and III, but a further increase could not be ascertained at the transition from degree of severity II to III. On the other hand, the duration of hypertension is of particular importance when a dilation of the aorta is present. Also between deformation of the heart and measure of the aorta close relations which may conclude to a homogenous development are to be seen particularly in the younger patients. The influence of the sclerosis of the aorta in the sense of an additional dilation of the aorta could not be clearly confirmed on the basis of our material. On the other hand, the frequency of calcium depositions significantly increased with growing age in the region of the aortic arce and in the group of younger patients with the duration of hypertension, whereas the different degrees of severity II and III had a smaller influence. It is interesting that several patients showed normal widths of the aorta despite a duration of the hypertension of more than 5 years and a degree of severity III.

Aorta, Thoracic↗
PubMed1978

[Cardiovascular x-ray findings, changes of the thoracic aorta, electrocardiographic and clinical parameters in hypertension. 1. Cardiovascular x-ray findings in hypertension].

We examined 142 hypertensive patients of special consulting hours for hypertension. In a subdivision into 3 degrees of severity of hypertension and into the age groups less than or equal to 50 years and greater than 50 years X-ray findings on the heart and on the large vessels near the heart were made. Patients with blood pressure values RRs greater than or equal to 160 Torr and RRd greater than or equal to 95 Torr had these findings in 78%. 56% of the test persons with a heart affected in the left ventricle (R1) were found and 23% of the test persons with left-prevailing heart affected on the two sides (R3). The positive correlation between age of the patients with hypertension, duration of hypertension and frequency of the heart deformation in the sense of the left-ventricularly affected heart and the left-prevailing heart affected on the two sides could statistically be ascertained. 62% of the patients less than or equal to 50 years and 89% of the patients greater than 50 years had these findings. In a duration of hypertension less than or equal to 5 years 64% had these findings, in a duration of hypertension greater than 5 years 64%. The total number of findings increases with the degree of severity of hypertension. In test persons with degree II of severity of hypertension (RRs 160-200 Torr, RRd greater than or equal to 95 Torr) 73% had these findings, in test persons with degree III (RRs greater than Torr, RRd greater than or equal to Torr) 86%. The relation of the heart deformation in the sense of the left-prevailing heart affected on the two sides between degree II and III of the severity of hypertension was contradictory. In hypertension II and duration of hypertension greater than 5 years the percentage of the test persons with left-prevailing heart affected on the two sides was 42%, in hypertension III and duration of hypertension greater than 5 years 19%.

Adult↗
PubMed1978

[Behavior of hypertension and cardiovascular findings in hypertension within an observation period of 10 years (the Wurzen study 1961-1971)].

In concert with literary data during a mass X-ray examination in 1961 we established in 5,517 men of the district Wurzen a frequency of hypertension of 13.6% and in 1971 in the same group of test persons a frequency of hypertension of 19.4%. The percentage of the pathological cardiovascular X-ray findings was in normotonus 10.4% in 1961 and 11.2% in 1971, in hypertension 22.3% in 1961 and 27.5% in 1971. The dependence on the age of the test persons, on the degree of severity of hypertension, and particularly on the duration of the hypertension is clear. For prevention of a hypertensive heart disease the early recognition of a hypertension and an early therapy are necessary. On the basis of our studies the making of cardiovascular X-ray findings from photofluorograms is not suitable as screening test for the hypertension. The value of blood pressure controls in mass X-ray examinations must be emphasized. Important is the collection of cardiovascular X-ray findings from photofluorograms of the thorax for the establishment of a hypertensive heart disease, of not recognized vitia and age-conditioned cardiac and vascular changes. It implies an optimum use of the material collected in the mass X-ray examination.

Adult↗
PubMed1976

[Methodological problems in the determination of biological age].

It is reported on a new method of the establishment of the biological age. The test battery designed comprises 12 parameters, from which a so-called biological index can be calculated which on its part serves as basis for the establishment of biological age. The realisability of the methods is demonstrated by examinations carried out on 340 healthy persons. The method developed for the geriatric practice is regarded as supplementation of the general medical examination and for the clarification of certain, above all gerontologically orientated questions.

Aging↗
PubMed1976

[Problems of food absorption with reference to age and obesity].

In 1,000 obese persons and 250 persons with normal weight detailed nutrition anamneses concerning the average daily intake of calories, carbohydrates, protein, fats, cholesterol, saturated and repeatedly unsaturated fatty acids were made. Obese persons took less food than persons with normal weight--findings which are to be explained by the different habits of eating in the dynamic (the hyperalimentation takes place above all here) and in the static phase of obesity. There were no age tendencies in women, whereas in men, beginning with the 4th decade of life, all the nutrients were taken in a smaller quantity than in adolescence.

Adolescent↗
PubMed1976

[Age dependent frequency of cytoplasmic antibodies].

In a random sample of so-called healthy blood donors under and over 60 years of age (n=196 of 10,593 donations by about 4254 donors) the frequency of antibodies (antibodies against smooth muscles, mitochondria, microsomes, brush border of proximal rat renal tubuli, connective tissue, and parietal cells) detectable by immuno-fluorescence was determined and compared with the incidence thereof in various groups of diseases. In general, two frequency peaks (up to 30 and over 50 years of age) were observed; however, statistical evidence was obtained for the second peak only (with p less than 0.001). In "healthy" blood donors past 60 there was observed a significantly higher frequency of occurrence of antibodies against parietal cells (p less than 0.001) and against connective tissue (p less than 0.01). An attempt has been made to classify antibodies into four groups depending upon age disease, with due consideration being given to the different clinical valency of antibodies. Different frequencies of occurrence of numerous antibodies are believed to be due not only to immune system aging, but especially to the not-yet elucidated disturbance of regulation of autotolerance by alteration of immune cells, which is subject to endogenous (e.g., genetic) and exogenous (e.g. viral) factors that are dependent on age rather than aging.

Adult↗
PubMed1975

[Influence of overweight on the load-capacity of the supporting and locomotion system in women].

119 50-year-old women were examined with regard to connections between apparatus of locomotion and overweight. Middle-aged women with overweight compared with women with normal weight more frequently complain of podalgias and of by Schober's signs objectifyable sacrodynias. Compared with women with normal weight in them a more frequent hyperlordosis can be established. The percentage of the degenerative spondylopathies of 61% and of the densitometrically established osteoporosis of 25.4% in the total material corresponds with literary data. There are no differences between women with normal weight and overweight. In contrast to persons with normal weight persons with overweight have only somewhat more frequently the combination of hyperlordosis with degenerative processes of the lumbar vertebral column. The biconcavity index established at the lumbar vertebral bodies is in the lower region in persons with overweight as well as in persons with normal weight. Osteoporotic lumbar vertebral bodies show a decreased frequently of spondylosis. There is no correlation between the radiological parameters established at the lumbar vertebral column and the objectified by Schober's signs decrease of the function of the lumbar vertebral column. A decreased height of the plantar arch and a correlating with this bredth of the step plane of the foot in adipose persons compared with normal persons we regarded as an expression of the increased load of the foot, also in such cases where a connection with the more frequent foot-complaints could not be ascertained. Perhaps it corresponds with that fact that only the developing flat-foot causes complaints. In general a positive correlation is to be found between the frequency of sacrodynias and podalgias.

Age Factors↗