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Biomedical subjects

I Sauer

Publications and source records attributed to I Sauer.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Clinical, biochemical and anthropometric studies and determination of biological age in relation to body mass in a longitudinal study].

On 46 adipose persons (25 males and 21 females) and 53 test persons with normal weight (35 males and 18 females) at the age of 25-40 years since 1976 clinical, biochemical and anthropometric investigations as well as the determination of the biological age have annually been performed. Several of the parameters established (e.g. cholesterol, triglycerides, fasting blood sugar, blood pressure among others) in the course of 9 years within the well-known normal regions draw towards the adequate valid limit value to the pathological entity. The results of the study distinctly show the central role of obesity for the development of risk factors. Despite the partly only with a certain tendency recognizable behaviour of single parameters after 9 years from our point of view the longitudinal method represents itself as a very well suitable method for establishing dynamic processes and risk factors of age.

Adult↗
PubMed1986

[Development of body weight in males of the Wurzen district 1961-1983].

In 1961, 1971 and 1983 additional medical parameters, among them body length and body weight, were established during the mass radiographies in the district of Wurzen. From the data of 7,670 males from the year 1983 for two 10-year age groups regression equations between body weight and body length were determined. The calculation of relative weights was performed on the basis of the optimum weights after Ott. The longitudinal comparison from 1961 to 1971 resulted in an increase of the number of persons with overweight by 17.7% during 10 years. The results of the examinations of the year 1983 showed that the trend to the increase of body weight continues in the male inhabitants of the district of Wurzen.

Adult↗
PubMed1986

[Relation between obesity and atherogenic risk factors in a longitudinal study].

Since 1980 clinical, biochemical and anthropometric examinations have been performed annually on 46 adipose patients (25 males, 18 females) and 53 test persons (35 males, 18 females) at the age of 25 to 40 years. Several of the established parameters (e. g. cholesterol, triglycerides, uric acid, blood pressure among others) in the course of the 5 years within the known normal regions drew towards the adequate limiting value to the pathological. The results of the study clearly show the central role of the overweight for the formation of risk factors. Despite the partly only in a certain tendency recognizable behaviour of individual signs after 5 years from our point of view the longitudinal technique represents itself as a very well suitable method to realize dynamic processes and risk factors of ageing.

Adult↗
PubMed1986

[Treatment of disorders of lipid metabolism with the new lipid regulator X50].

With the newly developed lipid regulant X 50 = 1-benzyl-3-(1-carboxyl-methylethoxy)-4-methylpyrazol 15 patient with primary hypercholesterolaemia and hypertriglyceridaemia were treated for 3 months. A significant decrease of the serum triglycerides by 47% in all patients and of the total cholesterol by 32% in half the patients (LDL cholesterol decrease 25%) was the result. Altogether an increase of the linoleic acid of 14% and a decrease of the uric acid of 16% were furthermore the result. There were practically no side effects.

Apolipoproteins↗
PubMed1986

[Noninvasive roentgen diagnosis of right heart function in patients with recirculation disorders and chronic nonspecific lung changes].

The non-invasive x-ray functional diagnostic electroradiographic method at the large vessels near the heart may enrich the radiological preliminary diagnostics of recirculation abnormalities. In chronic unspecific pulmonary diseases it can characterize the load of the right heart. Our studies should serve as a pilot study for the in future possible, simply to be handled non-invasive video-densitometry of the vessels near the heart in the preliminary diagnostics of cardiovascular diseases.

Cardiac Output↗
PubMed1985

[Changes in noninvasive cardiovascular parameters by inpatient weight reduction].

36 normotensive obese and 23 hypertensive obese were treated with an isokaloric reduction diet of 800 kcal/a day under clinical conditions over a 4-week span. Blood pressure and cardiac performance were investigated by means of non-invasive techniques such as systolic time intervals (STI) and calculated indices. A significant decrease was established in systolic time intervals such as left ventricular ejection time and total electromechanical systole, systolic and diastolic blood pressure, myocardial oxygen consumption and cardiac output. Heart rate, preejection index and stroke volume were not diminished under dietary treatment. No decrease of all parameters was found in obese normotensives with a weight reduction greater than 5% after dietary treatment.

Adult↗
PubMed1984

[Long-term behavior of serum fatty acids--results of a Leipzig gerontologic longitudinal study].

In the Leipzig longitudinal study performed from 1968 to 1980 in 383 test persons with healthy metabolism in 2-3--year time intervals gas-chromatographic analyses of the serum fatty acid pattern were carried out. The dependence upon age, sex, and body-weight the vasoprotective linoleic, linolenic and arachidonic acid increased and the vasoaggressive palmitinic and eicosatrienic acid decreased. Influences of age as well as the change of the feeding habits are causally discussed for this purpose.

Age Factors↗
PubMed1983

[Methods for the determination of psycho-social performance within the scope of a model for objectivizing biological age].

With the help of experimental findings of a randomized study concerning the dynamics of ageing of a reference population (365 persons of either sex between 18 and 73 years) the authors adopt a principal attitude to methodical questions in objectifying the biological ageing. It is above all demonstrated, if and in how far the psycho-sociometric methods used in a gerontological complex method developed for this purpose meet certain methodical requirements (objectifity, reliability, validity) and are effective from the practical and clinical point of view. On principle it is referred to the necessity of a sex-different interpretation of findings concerning the dynamics of ageing and to the possibilities and borderlines, to attract them for a total assessment of the performance. The clinical model demonstrated for objectifying the biological ageing of man opens a wide field of theoretical and practical possibilities to gain recognitions on dynamics and influencibility of human ageing.

Adolescent↗
PubMed1983

[Effect of obesity on cardiovascular performance].

On 55 healthy test persons with normal weight and 76 healthy middle-aged obese test persons the measurement of systolic time intervals was performed standing and lying. In 39 obese patients and 55 test persons with normal weight a load ergometry was carried out. No significant difference between persons with normal weight and extreme overweight was recognized with regard to the index of tension. However, there were clear differences between persons with normal and overweight as to the time of tension and left-ventricular ejection time lying and standing, independent of the behaviour of blood pressure. In persons with overweight a significantly lower cardiac output was found. The index of tension of obese persons with a degree of efficacy below 75 Watt was on an average 1.04. Only half of the persons with overweight reached a degree of efficacy of 100 Watt. In 32 obese persons with a degree of efficacy of more than 75 Watt the regulation of frequency and blood pressure did not differ from that of persons with normal weight.

Adult↗
PubMed1983

[Early rehabilitation and psychosocial problems of burns in childhood].

In the management of burns in childhood teamwork is even more important than in the treatment of other traumatic injuries. The authors describe their experience with more than 600 children referred to the center for burns of the University Children's Hospital, Zurich, between 1 November 1977 and 31 December 1982. The psychological state of the child during hospitalisation and the question of somatic and psychic reintegration into the community are very closely connected. 1. Early rehabilitation: The authors describe technical possibilities in the treatment of scars in children and stress the risks involved and possible mistakes. 2. Psychological problems: Recovery depends to a large extent on the reactions by the medical and nursing personnel. The difficulties which will be encountered if children are treated in a hospital not specialized in the treatment of burned children, are described and the indications for transfers of those children to specialized children's units are enumerated.

Age Factors↗
PubMed1982

[Serum immunoglobulins and third complement component in and after acute non-A/non-B hepatitis (author's transl)].

The serum levels of IgG, IgA, IgM, IgD and IgE and of the third complement component (C 3) were determined by the single radial immunodiffusion method in 69 serum samples of 34 female patients during (2nd and 4th week) acute non-A/non-B hepatitis and 2 years after infection. The levels were compared with those of circulating immune complexes measured by polyethylene glycol precipitation method. The levels of immunoglobulins and C 3 were similar to those of healthy persons. During the course of disease there were no significant relations with exception of an increase of IgD levels in patients with chronic course. The positive correlation of the levels of IgM and immune complexes at the first and second serum sample (r = 0,5914, r = 0,6366 respectively, p less than 0,001) could not be verified in patients with noncomplicated course (r = 0,203 8, n. s.) but it was highly significant in patients with chronic course (r = 0,9429, p less than 0,001). Determinations of immunoglobulins and immune complexes may therefore be prognostically helpful in patients with non-A/non-B hepatitis.

Adult↗
PubMed1981

[Behavior of serum lipid parameters--results of a longitudinal gerontologic study].

Within the Leipzig longitudinal study from 1968 to 1978 in 158 test persons (46 males, 112 females) cholesterol and the total fatty acid spectre were gas-chromatographically determined in regular intervals. Serum cholesterol as well as proportions of linoleic acid increased significantly. By the significant decrease of the palmitic acid the percentages of the saturated fatty acids altogether decreased despite increase of stearic acid. In these cases the differences between males and females as well as between persons with normal weight and overweight more and more evened up. Ascertained correlations existed between reduction of the relative weight and decrease or more insignificant increase of cholesterol on the one hand and increase of linoleic acid on the other. The latter phenomenon is above all to be traced back to the fat-reduced diet and to the diet rich in polyene fatty acids which was more and more applied mainly by older test persons in the course of the longitudinal study, which thus may lead to antiatherogenic constellations of serum fatty acids.

Aged↗
PubMed1981

[Metabolic risk factors in the very old].

55 patients well advanced in years of the vitality group I after Franke were examined according to clinical and laboratory-chemical criteria as well as by means of ECG in rest. The particular relations between metabolic risk factors and the occurrence of diseases of heart and circulation in persons well advanced in years were explained. Here could be established that persons who advanced in years, on the one hand, from the epidemiologic point of view show favourable laboratory parameters for the metabolic risk factors, on the other hand, however, slightly increased serum values of the risk factors may also be connected with old age. In a similar way the finding from the ECG in rest could be interpreted.

Aged↗
PubMed1981

[Determination of the systolic time interval in normal subjects from electrokymographic studies of vessels near the heart].

By means of electrokymography curves of the motion of the vascular margin of the large vessels near the heart, aorta and pulmonary artery, may be recorded noninvasively. Since these curves of motion widely correspond to the central curves of the arterial pulse it is possible to state systolic time intervals separately for the right and left heart. Analogically to the presphygmic index after Rentsch with global evidence on the left-ventricular function of the heart these are possible for the outflow way of the right ventricle, also by formation of the quotient of the electrokymographically established STI. Comparisons between right-ventricular and left-ventricular STI and relations to the at the same time electrokymographically stated dynamic parameters of the heart wall are the result. In the present paper on the basis of electrokymographical investigations on 24 test persons with healthy heart the concerning the contents reasonable STI with relatively slight statistical distribution and their quotient are determined as starting-point to further investigations.

Aorta↗
PubMed1981

[Preconditions for attaining advanced old age (author's transl)].

Generally speaking, we can say that the incidence of certain diseases in the various blood groups of the ABO system do not demonstrate a direct connection which might be used for the assessment of life expectancy, but that exogenic and genetic factors form a genetically determined functional unity in the development of certain characteristic features and of diseases. Innumerable influences of various types can cause diseases, primarily the high incidence of certain tumours in old age, climatic influences, overeating and malnutrition, furthermore abuse of coffee, tea, tobacco and alcohol, medicines and insufficient movement. It can be assumed that wherever blood group A is prevailing the genes of blood group A constitute a factor in the respective polygenic system. The impact of the blood group genes varies as a function of the underlying disease, the effectiveness of the exogenic factors and the general constitution of the individual patient.

ABO Blood-Group System↗