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Biomedical subjects

I Sarova-Pinhas

Publications and source records attributed to I Sarova-Pinhas.

At least 55 records · Page 3Linked to original sources
PubMed1981

Glutathione peroxidase activity in various types of blood cells in multiple sclerosis.

Previous studies demonstrated a significantly lower mean activity of glutathione peroxidase (GSH-Px) in erythrocytes of patients with multiple sclerosis than in control groups of normal subjects or patients with various neurological disorders. The present investigation has demonstrated that, in contradistinction to erythrocytes, a normal activity of GSH-Px is found in lymphocytes, granulocytes and platelets of multiple sclerosis patients. These results were obtained both with hydrogen peroxide, which serves as a specific substrate for selenium dependent GSH-Px, and t-butyl hydroperoxide which reacts both with selenium dependent and independent GSH-Px.

Blood Cells↗
PubMed1981

Premenstrual periodic paralysis.

A 17-year-old girl suffered from episodes of flaccid paralysis during each menstrual cycle. No relevant changes were found in potassium concentrations in serum or erythrocytes, nor in the values of pituitary, ovarian, adrenal or thyroid hormones. Acetazolamide administration prevented the attacks.

Acetazolamide↗
PubMed1980

[Myokymia].

Explore the source record for details and available documents.

Adult↗
PubMed1980

Hypokalemic periodic paralysis associated with multiple sclerosis.

A case is reported of a 46-year old male who has been suffering from recurrent episodes of quadriplegia, characteristic of hypokalemic periodic paralysis, for 28 years. During this period he has developed typical signs and symptoms of multiple sclerosis. The association of hypokalemic periodic paralysis and multiple sclerosis is extremely unusual.

Humans↗
PubMed1979

Decreased erythrocyte glutathione peroxidase activity in multiple sclerosis.

The mean activity of glutathione peroxidase (GSH-PX) in erythrocytes of 22 Israel-Jewish patients with multiple sclerosis (19.3 +/- 4.5 U/gHb) was significantly lower than in a control group of 30 Jewish patients with various neurological disorders (24.3 +/- 5.1 U/gHb). This observation confirms a similar finding of a decreased activity of GSH-Px in erythrocytes of multiple sclerosis patients in Denmark (Shukla et al. 1977). These results are discussed in relation to the possibility of selenium deficiency and to the recently described genetic polymorphism and ethnic variation of GSH-Px activity in human red cells. It is concluded that additional investigations are required in order to elucidate the cause of the decreased activity of this enzyme in red cells of patients with multiple sclerosis.

Erythrocytes↗
PubMed1977

Methotrexate treatment in dermatomyositis.

Two patients with dermatomyositis were treated with methotrexate, given intravenously. They were unresponsive to corticosteroids. The patients were bedridden and paralysed and one seemed to be in the terminal phase of the disease. The response to courses of methotrexate treatment was satisfactory and sustained over a 2-year follow-up period; muscle enzyme studies indicate that the muscle disease is no longer active. Although steroid therapy alone may be effective, its usefulness is unpredictable and may lead to dependence and undesirable side effects. Our experience with these two patients suggests that a combination of the two drugs may be justified as initial treatment in severe cases.

Aspartate Aminotransferases↗
PubMed1972

Subacute spongiform encephalopathy and its relation to Jakob-Creutzfeldt disease: report on six cases.

An account is given of six cases of Jakob-Creutzfeldt disease confirmed at necropsy. The rapid fatal outcome within three months was typical of the variety designated subacute spongiform encephalopathy (Nevin-Jones). The characteristic EEG changes were found to be of great value in making an early diagnosis and, together with akinetic mutism and myoclonus, constituted an easily recognizable picture. Treatment with idoxyuridine was ineffective in one case in which electronmicroscopy of brain biopsy material supported the diagnosis.

Adult↗