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Biomedical subjects

I Sarkany

Publications and source records attributed to I Sarkany.

At least 91 records · Page 5Linked to original sources
PubMed1976

Adverse skin reaction from vitamin K1.

Two patients with erythematous, tender, indurated plaques at the site of intramuscular injections of vitamin K1 are described. In one of these, condition was reproduced by the injection of a test dose. In both cases, there was associated liver disease. The red, indurated plaques cleared in 4-14 days. There have been two previous reports in the literature of similar lesions. Altough some of the patients showed sclerodermatous changes at the same site within 2 years of the injections. These unusual reactions have only been seen in patients with liver disease and when a variety of drugs have been administered. It may be that these factors are important in the initiation of the cutaneous response.

Adult↗
PubMed1976

Effect of bases and accelerants on the anti-inflammatory activity of topical corticosteroids.

The use of measurement of skin thickness in guinea pigs has been compared with other techniques for assessment of topical applications. This method has provided us with an accurate evaluation of the corticosteroid dose-response curve and the effect of bases. The method has shown that non-steroid prostaglandin synthesis inhibitors can also be demonstrated to possess topical anti-inflammatory activity. As expected, indomethacin acts synergistically when formulated with hydrocortisone. Contrary to our expectation, both salicylic acid and acetylsalicylic acid show antagonism with hydrocortisone. This finding may be of clinical significance. We have also found that a combination of salicylic acid and indomethacin produces striking inflammatory changes in guinea pig skin which points to interaction of these two drugs in the guinea pig. The relevance of this phenomenon to both the mode of action of the two drugs and their use in clinical practice remains to be elucidated, but preliminary tests suggest that similar changes take place in human skin.

Administration, Topical↗
PubMed1976

Piperazine hepatitis.

The first reported case of piperazine toxicity resembling viral hepatitis is described in a 25-year-old woman. The illness, which was severe, occurred after administration of the drug on two separate occasions. The evidence favors a hypersensitivity mechanism rather than a direct toxic effect of piperazine or its metabolites on the liver. The humoral or cellular immune basis for such hypersensitivity has not been elucidated.

Acute Disease↗
PubMed1975

Cell migration and DNA synthesis in organ culture of human skin.

Cell migration and DNA synthesis in organ cultured skin were studied. Cell migration leads to the formation of a new epithelial layer around the free edges of the dermis. No significant DNA synthesis occurs in this newly formed epithelium. In contrast, DNA synthesis in the original epidermis is maintained throughout the period of culture as shown by the uptake of radioactive thymidine. Addition of hydrocortisone to the culture medium increases cell migration, and phytohaemagglutinin, while dramatically stimulating mitotic activity, suppresses cell migration. These results show that an increase in epithelial cell division is accompanied by diminished cell migration whereas an increase in cell migration occurs in the presence of a decrease in epithelial cell division. The behavaiour of skin in organ culture during the first 48-72 h can be compared with that seen in wound healing.

Cell Division↗
PubMed1975

An improved method of assessing topical corticosteroid activity.

Topical application of ointment bases causes varying degrees of epidermal thickening in guinea-pigs. This is reproducible and can be accurately measured. Suppression of these changes was produced by addition of beta-methasone 17-valerate, fluocinolone acetonide, fluocinonide and hydrocortisone acetate. The inhibitory effect of these steroids was related to the type of corticosteriod, its concentration and the ointment base. The effect was still evident at extremely high dilutions of the steroids and could be measured at concentrations as low as 5 X 10(-5) % of fluocinonide in FAPG. This technique has the merits of being reproducible, sensitive and accurate. It should find a place among existing methods in assaying the efficacy of topical corticosteroids and in aiding in the selection of bases most suitable for formulation of these preparations.

Administration, Topical↗