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Biomedical subjects

I Sando

Publications and source records attributed to I Sando.

At least 109 records · Page 6Linked to original sources

Renal disease. Its pathology, treatment, and effects on the ear.

Twenty-six hemodialysis and renal transplant patients were studied for the effects of age, duration of kidney failure, amounts and types of treatment, disturbed calcium metabolism, and vascular disease on clinical and pathologic inner ear manifestations. Three subgroups of patients were compared with each other: (1) those having hearing loss of unknown etiology, (2) those having strial deposits, and (3) those having neither. Severity of treatment was not necessarily predictive for severity of inner ear disease. Within each subgroup there was wide variability and almost complete overlap for the factors studied when the three groups were compared. Cochlear strial deposits seem to bear little relationship to disturbed calcium meatbolism or to vascular disease, but their size may be related to the presence of hearing loss.

Adolescent↗

Anatomy of the para-vestibular canaliculus.

A histologic study of the para-vestibular canaliculus (PVC), its contents, and its relationship to the vestibular aqueduct (VA), is presented. 20 normal human temporal bones were fixed in 10% formalin solution, embedded in celloidin, and sectioned horizontally at intervals of 20 micrometers. Every tenth section was stained with hematoxylin and eosin (HE) and studied under a light microscope. Three significant observations were made. First, in 80% of the specimens, two rather than one PVC were found in the area of the vestibular orifice of the VA. Second, in 70% of the specimens, the PVC was found to merge with the VA rather than to enter the posterior cranial fossa (PCF) separately. Third, in all the specimens examined, a vein was seen to traverse the entire length of the PVC. However, in 17 specimens, no artery could be identified within the PVC. In the 13 (65%) specimens in which arteries could be identified in the PVC, the arteries extended only half the length of the PVC, from the PCF to the VA. In no specimen examined could arteries be seen extending the full length of the PVC from the PCF to the vestibule.

Arteries↗

Idiopathic pleomorphic midfacial granuloma (Stewart's type).

Idiopathic mid-facial granuloma is an unusual highly destructive disease which was virtually unknown prior to 1955. Great confusion exists, due in large part to the terminology applied to this entity as well as the clinical similarity of the process to other destructive mid-facial lesions. A classical case of idiopathic mid-facial granuloma of Stewart's type is presented, with characteristic lesions limited to the mid-face. Definitive histopathological features consist of pleomorphic inflammatory granulation tissue with patchy necrosis and no system lesions or neoplasia in the autopsy tissues.

Face↗

Sudden deafness and facial palsy from metastatic bronchogenic carcinoma.

A 52-year-old man developed sudden total bilateral deafness, and unilateral facial palsy, without other symptoms and findings. He died two months later of of bronchogenic carcinoma metastatic to dura, brainstem, pons, carebellopontine angle, cerebellum and cranial nerves III, VI, VII and VIII. There was bilateral internal auditory canal erosion. Tumour replaced right facial, acoustic and vestibular nerves. Tumour infiltrated spiral ganglion, cochlear nerve, cochlear aqueduct, and destroyed nearly all facial nerve fibres to the level of the stapedius muscle. No tumour cells were found on the left, but few fibres of facial, acoustic and vestibular nerves survived. Both ears showed some cochlear outer hair cell destruction. Metastatic tumour to temporal bone or dura should be considered when loss of peripheral VIIth or VIIIth nerve function occurs.

Brain Neoplasms↗