Search PubMed⌕ Search

Biomedical subjects

I Ono

Publications and source records attributed to I Ono.

At least 163 records · Page 9Linked to original sources
PubMed1984

Anticoagulation therapy for renal insufficiency after burns.

The changes in blood coagulation, fibrinolysis and kidney function and the effect of anticoagulation therapy using herapin were investigated in rabbits with full thickness skin loss burns covering 35 per cent of the total body surface area. Determinations of various kidney function tests, blood coagulation and fibrinolysis tests, blood viscosity and haematocrit values were made before burning and after 8 and 24h. Thirty rabbits were divided into a non-therapy group, an intravenous infusion group, a heparin group, an antithrombin III group and an antithrombin III plus heparin group and the results were compared. Oliguria and a disturbance of kidney function were noted 8 h after the burn in the non-therapy group. In the intravenous infusion group urine volume was well maintained although the early stage of non-oliguric renal insufficiency was noted. The changes noted in the intravenous infusion group were prevented almost completely in the heparin group but FENa and CH2O were elevated at 24h probably because antithrombin III activity was markedly depressed. In the antithrombin III group and the antithrombin III plus heparin group, however, creatinine clearance (Clcr) was moderately elevated while FENa and CH2O remained unchanged as compared with the values before the burn. The antithrombin III plus heparin group showed slightly better results than the antithrombin III group in Ucr/Pcr ratio, Clcr and CH2O. The results of the present study indicate that it is extremely effective to initiate appropriate fluid therapy immediately after a burn and to administer antithrombin III concentrate in combination with or without heparin for the prevention of acute renal insufficiency in patients with a severe burn.

Acute Kidney Injury↗
PubMed1984

Establishment and characterization of two human mixed mesodermal tumor cell lines from the same patient.

A cell line designated HIRS -BM was established from fluid aspirated from the sternal bone marrow of a 16-year-old female. Another cell line ( HIRS -PB) was derived from the peripheral blood of the same patient. Both lines grew well, multilayering rapidly without contact inhibition, and 62 serial passages were successively done within 28 months. Both cultures contained spindle- or fibrous-shaped cells that revealed neoplastic and pleomorphic features, and these cells were characterized as possessing cross-striations in the cytoplasm. The cross-striations were detected by phosphotungstic acid hematoxylin stain. Some elongated cells were stained positively with anti-myoglobin by use of periodic acid-Schiff methods. The primary tumor in the uterus was diagnosed as a mixed mesodermal tumor composed of adenocarcinoma and rhabdomyosarcoma cells. The karyotype exhibited hyperploidy and large submetacentric marker chromosomes, and the modal chromosome number was 84. No difference was found between the 2 cell lines except for growth behavior and heterotransplantability . HIRS -BM cells grew more rapidly and were highly transplantable. The HIRS -BM cells were transplanted into the subcutis of BALB/c nude mice and produced mixed mesodermal tumors resembling the uterine tumor, while the HIRS -PB cells could not be transplanted. Due to the histogenesis of the mixed mesodermal tumor being's obscure with histologic observations only, this study was performed to obtain data by tissue culture of the tumor and resulted in support of the combination theory reported in the literature in regard to tumor.

Adolescent↗
PubMed1984

Reconstruction of the esophagus by microvascular surgery.

After esophagectomy, free jejunal autografts were used for reconstruction in 11 patients and pedunculated colons in two patients. A microvascular technique was applied immediately after the resection. A vascular anastomosis gave a new blood supply for the free jejunal graft, and in the case of the pedunculated colon gave support to improve circulation. During the grafting procedure, neither cooling nor heparinization was needed. No graft failures have occurred. The main complication of free jejunal grafts was leakage of the proximal anastomosis of the bowel, but all three leakages healed spontaneously. Two supportive vascular anastomoses for the pedunculated colons were effective and caused no complication. All 13 patients could eat regularly at the time of their discharge.

Aged↗
PubMed1984

[Primary malignant tumors in the lung and larynx --a report of 37 cases].

For the past 20 years (from May 1962 to December 1982) the cases of lung cancer and laryngeal cancer treated in National Cancer Center Hospital are 2423 and 603 respectively. We have studied multiple cases of the lung and laryngeal cancers. The cigarette smoking is one of the most important environmental factors concerning the multiple cases of laryngeal and lung cancer would not be so significant in the future, if the cigarette smoking factor should be excluded.

Adult↗
PubMed1983

A comparison of AJC and JJC proposals on TNM classification of maxillary sinus carcinoma.

The proposal of the JJC, established in 1977 in an effort to establish a TNM classification of maxillary sinus carcinoma, proved superior to the American Joint Committee for Cancer Staging and End Results Recording (AJC) proposal in terms of reproducibility, well-balanced distribution of cases of T, and prognostication using TNM as the indices, after a nationwide analysis of 474 N0M0 Patients who were among the 541 patients first treated between 1970 and 1973 in 11 leading Japanese medical institutions. The number of patients, with their 5-year cumulative survival rates in parentheses, classified by T1, T2, T3, and T4 were as follows: AJC proposal - 0 (-), 21 (68%), 283 (44%), and 170 (31%); JJC proposal - 6 (83%), 148 (51%), 237 (40%), and 83 (22%). The 283 cases for T3 under the AJC classification are to be redistributed over three JJC T units of T2, T3, and T4, with the respective numbers of cases and 5-year cumulative survival rates of 133 (50%), 128 (41%), and 22 (26%). In a similar manner, the 170 T4 cases under the AJC classification are reclassified into 109 (37%) for T3 and 61 (20%) for T4 under the JJC proposal. The JJC proposal enables closer prognostication than the AJC.

Humans↗
PubMed1983

[Head and neck cancers--significance of salvage operation].

The crude and determinate 5 year survivals out of 264 cases were 28.4% and 34.6% respectively. There were 136 cases in which the recurrence located at the primary site only. Whereas surgery performed on 81 cases resulted in the determinal survival rate of 58.0%, radiation therapy for 42 cases could attained only 19.5% survival. Cryotherapy were performed on 4 localized recurrent lesions and all but one which died of other cause are living well for more than 5 years. In 58 cases, the recurrence appeared only in neck nodes. Determinate 5 year survival rate of 64.7% could be obtained out of 40 cases treated by radical neck dissection. Only 7.1% of cases treated otherwise survived more than 5 years. Results of treatment were poor in the 39 cases in which both the primary and neck nodes were involved by recurrences. Only one case survived more than 5 years which had undergone composite operation. Introduction of composite operation simultaneously combined with reconstruction extended the indication of radical therapy. Seventy-eight cases which would have been the candidate for palliative treatment underwent this type of surgery, and 41.0% of them survived more than 5 years. It is noteworthy that radical treatment is still reserved for many recurrent cases of head and neck carcinoma. And salvage operation, if indicated, promises the best results among various methods of treatment.

Brachytherapy↗
PubMed1983

Pull-through esophagectomy without thoracotomy.

Twenty patients with carcinoma of the hypopharynx, esophagus and thyroid underwent pull-through esophagectomy. Seventeen of them received combined resection of the larynx and trachea. Dissection of the lymph nodes at the upper mediastinum was performed in 11 patients by sternotomy. Seven patients received mediastinal tracheostomy after combined resection of the trachea and the larynx. Pull-through esophagectomy was followed by pharyngogastrostomy without thoracotomy via the posterior mediastinum. This technique is described in detail. Because there is no thoracotomy and ligation of the esophageal vessels is ensured, no pulmonary complications and no massive mediastinal hemorrhages occurred. There were no operative deaths. This operation offers excellent palliation and little morbidity. Moreover, the use of sternotomy and mediastinal tracheostomy for pull-through esophagectomy made it possible to dissect the upper mediastinal lymph nodes, and we could resect the affected trachea with certainty.

Esophageal Neoplasms↗
PubMed1982

Closure of total cheek defects with two combined myocutaneous free flaps.

Closure of a large, full-thickness defect after radical ablation of advanced cancers in the oropharyngeal region has often presented problems. We designed the one-stage, microsurgical free transfer of two musculocutaneous flaps-the latissimus dorsi flap and the serratus anterior flap-with one common nutrient pedicle formed by the thoracodorsal vessels. The serratus anterior flap was turned into the buccal mucosal defect, while the latissimus dorsi flap was placed in the cheek cutaneous defect. The flaps were then revascularized by anastomosing the nutrient thoracodorsal vessels to the selected recipient vessels. This particular procedure was successfully achieved in two clinical cases with large, full-thickness defects in the cheek. Functional disabilities after removal of two muscles were unexpectedly minimal in both cases.

Cheek↗
PubMed1982

[Moderate dose methotrexate with citrovorum factor rescue therapy in the treatment of head and neck cancer].

A clinical trial of moderate dose methotrexate (MTX)-CF rescue was conducted in 12 institutions. Thirty-seven patients with head and neck carcinoma entered this trial, of which 32 were evaluable. MTX was administered 350 mg/m2 (500 mg/body) by i.v. drip over 6 hours. Three hours after completion of MTX infusion, CF rescue was started. There was no complete response in 32 patients. Nine patients showed partial response with the response rate of 28%. The response rates were 21% for the group of patients treated previously, and 75% for the group untreated previously. MTX concentration in plasma was determined at 6, 24, 48 and 72 hours after the initiation of MTX infusion, and the assay results revealed a safe range. GI disturbances were seen at the rates of 11 to 38%. Bone marrow suppression was mild and no renal toxicity was observed. We concluded that the moderate dose MTX-CF rescue therapy was useful for head and neck carcinoma. As a next step, we are planning to conduct a clinical trial of high-dose MTX.

Adult↗