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Biomedical subjects

I Nordenson

Publications and source records attributed to I Nordenson.

At least 73 records · Page 4Linked to original sources
PubMed1980

Prevention of chromosomal breakage in Fanconi's anemia by cocultivation with normal cells.

The frequency of aberrations in cultured lymphocytes from patients with Fanconi's anemia was significantly reduced when the cells were cocultivated with normal human lymphocytes. The results suggest that most of the chromosomal aberrations observed in cultured cells from Fanconi patients arise during cultivation and that the presence of normal cells prevents chromosomal damage by means of a hitherto unknown mechanism.

Anemia, Aplastic↗
PubMed1980

Alpha 1-antitrypsin phenotypes in Northern Sweden.

By means of isoelectric focusing the alpha 1-antitrypsin phenotypes were examined in 1,869 Swedes from northern Sweden, 300 Finns and 217 Swedish Lapps. The M2 frequency was low among the Lapps and in the northeastern part of Sweden. The frequencies of the S and Z genes were low in the Lapps and in the north-Swedish population. The frequencies of rare phenotypes among Finns from northern Finland were significantly higher than among Finns from southwestern Finland and Aland Islanders.

Finland↗
PubMed1979

Chromosome aberrations in psoriatic patients treated with arsenic.

A significantly increased frequency of chromosomal aberrations was found in lymphocytes from eight psoriatic patients previously treated with arsenic than in lymphocytes from eight psoriatics with no such previous treatment. In most patients the arsenic therapy was discontinued more than 15 years ago. In the arsenic-treated group a statistically significant heterogeneity was found with respect to the frequency of aberrations. The frequency of sister chromatid exchange was not increased in the arsenic-treated patients.

Adult↗
PubMed1977

Different composition of the eosinophilic bone marrow pool in reactive eosinophilia and eosinophilic leukaemia.

The composition of the eosinophilic cell series in the bone marrow has been analysed in 10 patients with a pronounced reactive eosinophilia (RE) and in 2 with eosinophilic leukaemia (EL). An imparied differentiation of the eosinophils was found in the EL patients compared with the RE group. Thus the ratio of eosinophilic promyelocytestmyelocytes: segmented eosinophils was 9.2 and 9.1, respectively, in the patients with EL and 0.1--3.1 (average 1.3) in the RE patients. It is suggested that EL is characterized by an impaired differentiation of the eosinophilic bone marrow cells and that the recognition of this abnormality is of value in the diffential diagnosis between EL and RE.

Adult↗
PubMed1977

Chromosome aberrations in workers exposed to arsenic.

The occurrence of chromosome aberrations was studied in short-term cultured lymphocytes from nine workers exposed to arsenic at the Rönnskär smeltery in northern Sweden. In the smelter workers, 87 aberrations were found in 819 mitoses. The number of aberrations varied individually from 0 to 25 aberrations per 100 cells. In a control material 13 aberrations were found in 1012 mitoses. The frequency of chromosome aberrations was significantly increased among the smelter workers, but due to the simultaneous exposure to other agents the effect of arsenic per se can not be assessed with certainty.

Arsenic Poisoning↗