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Biomedical subjects

I Nordenson

Publications and source records attributed to I Nordenson.

At least 55 records · Page 3Linked to original sources
PubMed1983

Population studies in northern Sweden. XI. The Duffy blood group polymorphism.

Frequencies of the Duffy blood groups were studied in 222 Swedish Lapps and in a series of 3,151 Swedish conscripts and blood donors from the counties of Norrbotten and V asterbotten in northern Sweden. The conscripts and blood donors were distributed according to place of birth into 23 subpopulations. The frequency of the Fya gene among the Lapps was significantly higher than that in the Norrbotten and V asterbotten populations. The inbreeding coefficient FST for northern Sweden was found to be 2.8 . 10(-3) and significant (p less than 0.05). The Fya gene frequency in V asterbotten county was significantly higher than that in Norrbotten county. The overall picture of geographical variation of the Fya gene was not explainable in terms of Lappish and Finnish influence, it was rather contrary to the expected ethnic influence. The reason for this discrepancy is discussed.

Blood Group Antigens↗
PubMed1982

Establishment and characterization of a human EBV-negative B cell line (MN 60).

A permanent cell line, MN 60, was established from the peripheral blood of a patient with an acute lymphoblastic leukemia (ALL) classified morphologically as being of the L3 type. Cell growth started rapidly in vitro and no feeder cells were needed. Cells of the MN-60 line were identical to the original leukemic cells with respect to surface immunoglobulin (Ig) expression and karyotype, including the presence of four marker chromosomes [1q+, 6q-, t(8;14)]. Continuous proliferation was maintained in stationary suspension culture with a doubling time of 25 h. The cells were tumorigenic in athymic nude mice and had the capacity to form colonies in semi-solid medium in vitro. Monoclonal surface Ig (mu lambda) was demonstrated whereas no cytoplasmic immunoglobulin could be demonstrated. The MN-60 cells were Epstein-Barr virus (EBV) negative as evidenced by EBNA tests and by nucleic acid hybridization studies. The cells expressed HLA-A-C, HLA-DR. beta 2-Microglobulin and cALL, but not Fc gamma. C3, sheep and mouse red blood cell receptors. No reactivity was found with anti-glycophorin A or the anti-BL 38.13 monoclonal antibody. Cell growth was retarded in the G0/G1 phase of the cell cycle after incubation with leukocyte interferon, hydrocortisone, phorbol myristate acetate and dimethyl sulphoxide.

Adult↗
PubMed1981

Familial X-linked mental retardation and fragile X chromosomes in two Swedish families.

X-linked mental retardation (MR) associated with a fragile X chromosome was found in two Swedish families. The fragile X chromosome was demonstrated in 5/5 boys with mental retardation. Clinical data on four of these boys are presented. In one of the families, the mental retardation was associated with macro-orchidism, large hands and large, folded ears. In the other family, macro-orchidism was not seen, possible because the boys were younger. Fragile site X chromosomes were also seen in three obligate carriers. A summary of earlier published cases of X-linked MR associated with the fragile X chromosome is given.

Abnormalities, Multiple↗
PubMed1981

Increased frequencies of chromosomal abnormalities in families with a history of fetal wastage.

In twenty couples with a history of repeated fetal wastage, chromosomal abnormalities in cultured lymphocytes were analyzed with standard, G- and C-banding techniques. The analyses revealed five individuals with a variant chromosome #1 (1 qh+) and one individual with an extra small unidentifiable fragment or ring chromosome in about 50% of the cells. In the remaining 14 couples, an increased frequency of chromosomal breakage was found, compared to the frequencies in 11 couples with two children and no reported abortions. Eighteen out of 40 individuals (45%) in the families with fetal wastage were found to have cytogenetic abnormalities. None of the 22 controls showed such abnormalities.

Abortion, Habitual↗
PubMed1981

Population studies in northern Sweden. X. The MN blood groups.

Frequencies of the MN blood groups were studied in a material of 3,312 conscripts and blood donors from the counties of Norrbotten and Västerbotten in northern Sweden. The individuals were distributed according to place of birth into 23 subpopulations. The frequency of the M gene was significantly higher in Norrbotten county than in Västerbotten county. The overall picture of geographical variation was, however, not explainable in terms of Lappish and Finnish influence. In Västerbotten county a significant departure from the Hardy-Weinberg equilibrium (excess of heterozygotes) was found. The inbreeding coefficient FST was found to be high (5.3 . 10(-3)) and significant (p less than 0.001) in Västerbotten county, but low (1.2 . 10(-3) and statistically not significance in Norrbotten county.

Consanguinity↗
PubMed1981

Microcephaly, mental retardation and chromosomal aberrations in a girl following radiation therapy during late fetal life.

A human foetus was heavily irradiated in the thirtieth to the thirty-third week due to carcinoma of the uterine cervix of the mother. Irradiation after 20 weeks of pregnancy is thought not to produce severe abnormalities. However, the child showed microcephaly, mental retardation, stunted growth, microphthalmus, retinal degeneration, cataract and defective dentition. Cytogenetically the frequencies of both chromatid and chromosome breaks were increased.

Abnormalities, Multiple↗
PubMed1981

Chromosome aberrations in cultured human lymphocytes exposed to trivalent and pentavalent arsenic.

Cultured human lymphocytes were exposed to trivalent (NaASO2) and pentavalent (Na2HAsO4) arsenic in concentrations comparable to the arsenic levels found in the urine of copper smelter workers. Significantly increased frequencies of chromosome aberrations (gaps, chromatid breaks, chromatid exchanges and chromosome breaks) were found after exposure to trivalent but not pentavalent arsenic. This effect was not found when nonstimulated (GO) lymphocytes were exposed to trivalent arsenic and then cultured. The rate of sister chromatid exchanges was also found to be increased after exposure to trivalent arsenic. Thus results suggest that trivalent arsenic is more genotoxic than pentavalent arsenic and that arsenic exerts its effect mainly during cell division.

Arsenates↗
PubMed1981

A study of chromosomal aberrations in miners exposed to diesel exhausts.

A study was made of chromosome aberrations in cultured lymphocytes from a group of 14 miners exposed to diesel exhausts and a reference group of office employees and construction workers. No increased frequency of chromosomal aberrations was observed. The frequency of chromosomal aberrations (both gaps and breaks) was, however, found to be associated with smoking.

Adult↗
PubMed1981

Incidence of Down's syndrome in Sweden during the years 1968-1977.

The incidence of Down's syndrome has been studied among children born in Sweden during the years 1968-1977. The risk for mothers of different ages of bearing such a child did not change during these years. This does not exclude that a change in incidence might have occurred in smaller areas of the country but escaped detection for statistical reasons. A higher than expected number of children with Down's syndrome were born in a few communities, which most likely is a chance event. No correlation could be detected between the incidence of Down's syndrome and a number of socioeconomic variables. The correlation with maternal age was studied in detail. There was a significant excess of males among both the newborn children with Down's syndrome and fetuses with trisomy 21 aborted after prenatal diagnosis. A similar tendency was found among the cases with a chromosome mosaicism but not among those with a translocation. Two hypotheses are put forward to explain the excess of males with trisomy 21.

Adolescent↗