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Biomedical subjects

I Moseley

Publications and source records attributed to I Moseley.

47 records · Page 3Linked to original sources

Antibody to human T-lymphotropic virus type 1 in West-Indian-born UK residents with spastic paraparesis.

Of 13 West-Indian-born UK residents with spastic paraparesis of unknown cause, 11 were tested for serum antibody to human T-cell lymphotropic virus type 1 and all were positive. Their magnetic resonance imaging scans were normal or showed only minor abnormalities in the brain, and the spinal cord was normal in the 5 investigated. Of 48 patients with multiple sclerosis, mainly caucasian, none had antibody to HTLV-1 in the blood.

Adult↗

Interpreting the skull X-ray.

With the introduction of other noninvasive imaging procedures, indications for X-rays of the skull have become fewer and more specific. Their correct interpretation remains important, however, to ensure not only that significant abnormalities are not overlooked, but--perhaps more importantly--that failure to recognize normality does not have adverse effects on management.

Bone Diseases↗

Thoracolumbar intraspinal tumours presenting features of raised intracranial pressure.

Five patients are described in whom a benign or malignant thoracolumbar tumour, producing increased level of cerebrospinal fluid protein, was associated with hydrocephalus or papilloedema or both. A review of the clinical and laboratory features in these and 40 published cases underlines the difficulty in explaining the increased intracranial pressure in such patients. Slow absorption of cerebrospinal fluid as a result of the elevated protein levels or recurrent subarachnoid bleeding may play a part. When patients are discovered to have communicating hydrocephalus or a syndrome resemlbing benign intracranial hypertension, the finding of increased cerebrospinal fluid protein or any symptoms or signs relative to the spine should suggest the possibility of an intraspinal tumour.

Adult↗

The oil myelogram after operation for lumbar disc lesions.

Post-operative myelograms in patients with renewed or persistant pain in the back or sciatica after lumbar disc surgery were reviewed in an attempt to differentiate between recurrent disc prolapse and other changes, particularly scarring and inflammation of the meninges. The most useful sign of recurrent disc prolapse was anterior indentation of the iophendylate (Myodil) column opposite a disc space. Inflammatory changes in the meninges were indicated by loculation of the subarachnoid space, matting or marked swelling of the nerve roots, irregularity of the theca, and by the absence of a posterior bulge of the subarachnoid space at the level of the operation. Waisting of the contrast medium column, non-filling of nerve root sheaths, complete myelographic block and posteriorly placed indentations were confirmatory evidence of the presence of disease, but not helpful in determining its nature.

Humans↗

Therapeutic embolisation of the external carotid arterial tree.

Intra-arterial embolisation is a valuable adjunct to the treatment of many vascular lesions, including neoplasms such as glomus tumours or juvenile angiofibromas, and arteriovenous malformations. Its place in the management of the individual patient should be established before any surgical procedure is carried out, as this may prejudice the eventual result. The indications for the procedure, the technique, and possible complications are discussed in this paper, and it is emphasised that the latter are best avoided by the use of a scrupulous technique and adequate technical facilities.

Adult↗