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Biomedical subjects

I Mehdi

Publications and source records attributed to I Mehdi.

At least 19 recordsLinked to original sources
PubMed1999

Comparison of five different treatment regimens for H. pylori eradication.

AIM: Treatment response to five different H. Pylori eradication regimens were evaluated to see which is the best regimen in our setup. METHODS: Patients presenting with upper GI symptoms of acid peptic disease underwent upper GI endoscopy and an antral CLO test. All those with a positive CLO test were included in the study. The study was carried out over a year and one trial was followed by another. The treatment regimens comprised of (1) Omeprazole 20 mg once a day, colloidal bismuth subcitrate 120 mg three times a day, Metronidazole 200 mg three times a day (18 cases). (2) Colloidal bismuth subcitrate three times a day, furazolidone 100 mg three times a day, metronidazole 200 mg three times a day (28 cases). (3) Omeprazole 20 mg once a day, Clarithromycin 500 mg twice a day (21 cases). (4) Lansoprazole 30 mg once a day, Amoxycillin 500 mg three times a day (21 cases). (5) Lansoprazole once a day, Amoxycillin 500 mg three times a day and Roxithromycin 150 mg twice a day (14 cases). Therapy for all 5 groups comprised of 14 days. Endoscopy and CLO test were done prior to the entry in the trial and at 28 days to see the response. RESULTS: Meta analysis was done for all the 5 regimens. For the purpose of analysis patients were divided into 2 groups, i.e., those with peptic ulcer and positive CLO (peptic ulcer disease (PUD) and those without peptic ulcer but positive CLO test (Non ulcer dyspepsia (NUD). PUD was seen in 14 of 18 cases in group 1, 18 of 28 cases in group 2, 16 of 21 cases in group 3, 6 of 21 cases in group 4 and 3 of 14 cases in group 5. In PUD after 14 days of therapy, lesions healed and CLO became negative in 50% cases each in group 1 and 2, 56% in group 3, 83% in group 4 and all in group 5, while in NUD, 25%, 60%, 80%, 47% and 82% respectively showed H. Pylori eradication. CONCLUSION: Of the different therapies one proton pump inhibitor with two antibiotics gave best results in ulcer healing and H. pylori eradication in ulcer and non ulcer dyspepsia.

Anti-Bacterial Agents↗
PubMed1998

Esophageal variceal banding--the local experience.

Banding of esophageal varices was done in 29 patients suffering from acute variceal bleeding. In 13 patients this was the first bleed while in 16 it was recurrent. Five patients had large grade III (polypoid) varices while others had grade II varices. Banding was done using multi band ligator and 4-6 bands were fired per session. Repeat endoscopy at 3 weeks revealed persistence of varices requiring second session of banding in 11 cases and small varices (difficult to band) in 9 cases. Two patients expired due to persistent bleeding and 2 bled from esophageal ulcers. Both patients settled with conservative treatment. A third session of banding was required in 5 cases only. None of the cases developed any major complication. In our setting where expertise for sclerotherapy is scarce and cost of sclerosants is high; banding appears to be a cost effective modality for the management of variceal bleeding with a low complication rate.

Adolescent↗
PubMed1998

Frequency of gastrointestinal tumours at a teaching hospital in Karachi.

Malignant gastrointestinal tumours are amongst the commonest tumours exhibiting an annual increase globally. There is a change in the morphological site of involvement observed over the years. In this study biopsy proven malignant gastrointestinal tumours seen at Jinnah Postgraduate Medical Centre, Karachi from 1961-1992 were analyzed with reference to age, sex, topography and histology. The study showed an increase in malignant gastrointestinal tumours over the years, from 9% in 1961 to 17% in 1992 with respect to all malignant tumours reported. The tumours affected a much younger age in our population, 74% occurring between 35-64 years of age. Carcinoma oesophagus accounted for 10% of all malignancies (48.7% male and 62.4% female gastrointestinal tumours), while gastric carcinoma remained unchanged (14% male and 9% female GI tumours). The colorectal carcinoma (25.4% of male and 20.1% of female GI tumours) and carcinoma pancreas (1.2% male and 1.5% female GI tumours) were less frequently seen. It was observed that malignant gastrointestinal tumours have increased significantly over the years in our local population as part of international trend and are occurring at a much younger age as compared to western population. Carcinoma oesophagus was seen more frequently than gastric carcinoma and colorectal carcinoma. A substantially higher number tend to be more anaplastic being seen at an advanced stage of disease at the time of diagnosis.

Adolescent↗