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Biomedical subjects

I Mano

Publications and source records attributed to I Mano.

At least 37 records · Page 2Linked to original sources
PubMed1980

[CT scanner].

Explore the source record for details and available documents.

Humans↗
PubMed1976

Pathological studies of the animals replaced totally with the artificial heart. Part I. Concerning lungs, natural heart, and brain.

Pathological studies using routine pathological technics, microangiography and electron microscopy were performed on the 28 goats with an artificial heart (including 2 goats which survived for 30 and 37 days). In this paper, the brain, natural heart, and lungs of the goats were discussed. No special findings were seen in the brain except for rare infarcted areas. The natural heart almost always showed infarction-like lesions in the sub-endocardium and myocardium at the cut surface. The longer the animal survive, these findings became the more serious. The light microscopic findings on the lungs were classified into 6 groups. The most important findings of them are massive, diffuse exsudation with hemorrhage and its changes to chronic status. The main pathophysiological status, causing the pulmonary lesions, seemed to be peripheral circulatory insufficiency with increased permeability of peripheral vessels, especially of venulae. Thrombi were detected more frequently in the kidneys and lungs than in any other organs. The vascular walls where the thrombi were attached to, where often seen to be damaged, so that almost all thrombi were thought to be formed in the local vessels in situ, but not in the artificial heart. The main clinical causes to the pulmonary insufficiency were thought to be surgical operation including anesthesia, functional incompleteness of the artificial heart, etc.

Angiography↗
PubMed1976

Pathological studies of the animals replaced totally with the artificial heart. Part II Concerning liver, gastrointestinal tract, kidney, and general discussion.

Twenty-eight goats with an artificial heart (AH) were studied pathologically. Being continued from the previous report, the liver, gastrointestinal tract, and kidneys were taken up in this paper and finally, general discussion was done to get our ideas in shape concerning the pathophysiological status of the goat. Central necrosis of the liver was always observed in the goats which survived for over 140 hours. This finding seemed to be caused mainly by circulatory insufficiency of the portal vein at the latter half of the survival time. Microscopic findings of degeneration, necrosis, and edema were commonly observed at the walls of gastrointestinal tracts, when goats showed poor apetite, mucous feces and constipation. But these problems have been improved by application of a new control method to regulate the output of AH system within a goat's physiological range since October 1974. The lesions seen in the kidneys are classified into 5 groups. The most important findings of them are lower nephron nephrosis and cortical necrosis, both of which indicate the occurrence of long standing vasoconstriction of proximal renal arteries. By means of microangiographic method and others, thrombi were detected frequently in the kidneys. The vascular walls, where thrombi were attached to, were often damaged. Therefore, these thrombi were thought to be formed in the local vessels in situ through renal circulatory insufficiency. The renal pathological lesions have been also improved and severe renal failure from which the previous goats could not escape, has been lessened since the application of a new AH control method. As a whole, the main pathophysiological status of the animals replaced by the AH are thought conclusively to be peripheral circulatory insufficiency. This would be caused by abnormal hemodynamics, so that, the essential clinical etiology is thought to be AH function itself.

Animals↗
PubMedDate not supplied

Direct coronal CT scanning for the body.

A direct coronal CT scanning technique for the trunk, named "Quasi-Coronal" CT, is presented and its usefulness demonstrated with clinical examples. Patients are placed in the lateral position on a wide plate laid on the scanner bed and instructed to assume various special postures. An important concept of this technique is to obtain the tomograms in which target organs with predominant longitudinal orientation are directly imaged in the coronal plane. An analysis of artifacts due to "Out of Field" objects is presented. When properly performed, "Quasi-Coronal" CT can provide useful additional information, despite having some limitations.

Aged↗
PubMedDate not supplied

A system for the positioning correlation between computed tomographs and conventional radiographs.

The authors have presented a special system which enables us to understand the positioning relationship between transverse CT images and conventional radiographs. With this system the image on a X-ray film is first changed into a video image and second, the computed radiograph which has the positioning information for each CT image is superimposed on it electronically. Finally the computed radiograph is eliminated except for the positioning lines of the CT scanning. The image thus obtained is called a "Replaced Computed Radiograph (RCR image)". This image is then changed into a digital image and manipulated in the same manner as its CT images. We have utilized this system for 22 clinical cases and recognized it to be useful for current integrated-radiography.

Aorta, Abdominal↗
PubMedDate not supplied

Proton nuclear magnetic resonance imaging of acute experimental cerebral ischemia.

To determine the efficacy of proton nuclear magnetic resonance (NMR) imaging in documenting acute ischemic infarction and to characterize the changes in these images during the first 24 hours following the ischemic insult, serial NMR imaging was performed in gerbils that had undergone unilateral carotid artery ligation. No significant changes in the signal intensity, T1 or T2 relaxation times were noted for either asymptomatic animals or the control hemisphere of symptomatic gerbils. There was a significant increase in T1 and especially T2 relaxation times and in both the relative signal intensity and Hf(v) for the ischemic hemisphere of symptomatic gerbils. These parameters appeared to increase linearly over 24 hours. The ischemic lesion first could be detected by NMR as early as 3 hours after carotid artery ligation, our earliest time point. The physiologic significance of these changes is discussed. These data suggest that NMR imaging may have significant diagnostic importance for acute cerebral ischemia and infarction in man.

Acute Disease↗
PubMedDate not supplied

Fast spin echo imaging with suspended respiration: gadolinium enhanced MR imaging of liver tumors.

Magnetic resonance (MR) imaging of 43 patients with hepatic tumor was performed during suspended respiration using a fast scan spin echo (SE) technique (SE 200/40) with a single excitation. The resulting images were superior in terms of image quality to conventional ones. Due to the lack of soft tissue contrast, 38 patients received Gd-diethylenetriaminepentaacetic acid (DTPA) at 0.05 mmol/kg and serial scanning (CE-MR) was repeated. Twelve of 14 hepatomas showed isointensity or slightly reduced intensity compared with the liver in unenhanced MR. All metastases (nine patients) showed low signal intensity that was statistically significant (p less than 0.001) in differentiating between hepatomas and metastatic liver tumors. With contrast enhanced MR, both hepatomas and metastases showed changes that cannot be further classified until more cases have been examined. In all 12 cavernous hemangioma cases, Gd-DTPA pooling was observed with extremely high contrast, which was a pathognomonic sign. In fact, four cavernous hemangiomas in two patients with a diameter of 1.0 cm were successfully imaged.

Adult↗