[Rehabilitation of patients suffering from chronic diseases].
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Biomedical subjects
Publications and source records attributed to I Magyar.
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Using the artificial endocrine pancreas the insulin requirement of diabetics was determined on a standard diet during a fasting period of 12 hours or a 6-hour resting fasting period in the night. Values characteristic of the individual type of diabetes ranging from 507 mU/h to 1410 mU/h were found. The basal and the modulating insulin requirement were both determined. A considerable diurnal variation of the modulating insulin-requirement was demonstrated with the highest value in the morning and the lowest in the evening. In order to cover the basal insulin requirement the corresponding quantity of a very long acting insulin was given with supplements of short acting insulin 2--5 times during the day to obtain a continuous normoglycaemic state. This procedure proved to be optimal in the treatment of pregnant diabetics.
The plasma cholic acid, chenodesoxycholic acid and desoxycholic acid levels were studied by spectrofluoremetry in 153 cases. The values of 67 controls with no evidence of hepatobiliary or intestinal disease were compared with those of 86 patients with liver and biliary tract disease. The fasting values failed to provide more diagnostic information than did conventional laboratory assays. Plasma bile acid concentrations exceeding 2.5 mu mol/l are conclusive of liver or biliary disease. A cholic acid/chenodesoxycholic acid quotient higher than 1.0 is a sign of cholestasis. Estimation of bile acids after food intake was found more informative. The plasma cholic acid- and chenodesoxycholic acid levels underwent a considerable increase 1 to 2 hours after meals. A more marked increase of chenodesoxycholic acid than of cholic acid (the ratio of the two being in excess of 1.0) is indicative of cholestasis and is most marked in primary biliary cirrhosis.
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