Search PubMed⌕ Search

Biomedical subjects

I Katayama

Publications and source records attributed to I Katayama.

At least 289 records · Page 16Linked to original sources
PubMed1985

Autoimmune progesterone dermatitis with persistent amenorrhoea.

A case of autoimmune progesterone dermatitis is reported. The patient developed a recurrent eruption, primarily on the extremities, after receiving oral progesterone for the treatment of persistent amenorrhoea. Intradermal injection of 17 alpha-hydroxyprogesterone produced a positive skin reaction after 30 min, but no delayed onset reaction was observed. A patch test with progesterone in petrolatum was negative. The lymphocyte transformation test was normal. Histamine release from passively sensitized peripheral blood leukocytes was increased by progesterone preincubated in normal serum as a stimulating antigen. Conjugated oestrogen therapy suppressed the rash. Cyclical eruptions with elevated basal body temperature persisted for more than 20 months without menstruation.

Adult↗
PubMed1985

Tissue plasminogen activator inhibitor in the epidermis.

The presence of a tissue plasminogen activator inhibitor in the epidermis was investigated. A partially purified tissue plasminogen activator from a Bowes melanoma cell line medium was used as a tissue plasminogen activator. Extracts of epidermis dissolved in a 10 mM phosphate buffer, pH 7.0, were found to contain a tissue plasminogen activator inhibitor. The same extracts also contained a urokinase inhibitor. It is not clear whether these inhibitors are the same. This study is the first to show the existence of a tissue plasminogen activator inhibitor in the epidermis.

Adult↗
PubMed1985

Hapten-specific prophylaxis of murine contact sensitivity by DNP-amino acid derivatives.

In mice, the elicitation of DNFB contact skin reaction was suppressed by the intravenous injection of relatively small amounts of DNP-amino acid conjugates when given at the same time of challenge test. Maximal suppression achieved was around 70% when optimal doses of DNP-amino acid were administered. The suppressive activity of 4 different amino acids, i.e., DNP-L-lysine, DNP-S-cysteine, DNP-alanine, and DNP-glycine, was nearly the same, respectively. This inhibitory effect was hapten-specific, and it failed to suppress the strong skin reaction elicited in cyclophosphamide-pretreated mice. Using the lymphocyte culture system, low doses of DNP-amino acid also suppressed the antigen-specific proliferation of sensitized lymph node cells (T prlf). Preincubation of sensitized cells with DNP-amino acid eliminated the transfer activity of T-DH cells as demonstrated previously. The mixture of lymph node cells and spleen cells from DNP-L-lysine-treated mice in vivo also suppressed the elicitation of skin reaction when transferred to recipient mice sensitized 5 days previously. Transfer studies demonstrated that this suppression was mediated by Lyt 1.2 (+), Thy 1.2 positive cells in vivo.

Alanine↗
PubMed1985

Non-IgG1 nature of cutaneous basophil hypersensitivity factor in contact sensitivity. III. Cutaneous basophil hypersensitivity factor promotes histamine release from guinea pig bone marrow basophils after antigenic stimulation.

Cutaneous basophil hypersensitivity factor (CBH-F) from the sera of 1-fluoro-2,4-dinitrobenzene contact-sensitized guinea pigs promoted histamine release from bone marrow basophils in the presence of the antigen, dinitrophenylated epidermal microsomes as well as in vivo activity to induce CBH reaction in naive recipients and in vitro activity to mediate antigen-dependent basophil chemotaxis. The amount of histamine released was around 20% of the total release when compared to that of concanavalin A-induced basophil degranulation (50-60%). Divalent cations were required in this reaction because addition of EDTA completely suppressed histamine release from passively sensitized basophils with CBH-F. Though it is not known at present whether the same molecule is involved in basophil chemotaxis and histamine release, this histamine-releasing activity was recovered in the same preparations with basophil chemotactic activity after several purification steps.

Animals↗
PubMed1985

Epstein-Barr virus infections in hairy cell leukemia patients in the presence of complement-dependent neutralizing antibody.

Immune system status was characterized in patients with hairy cell leukemia (HCL) with respect to explaining their chronic or recurrent infections with Epstein-Barr virus. Measures of cellular immune responsiveness for a group of 11 HCL patients were, in general, decreased when expressed as the proportion of tested patients with values less than 2 S.D. below mean values for a group of 17 healthy adults: T-cell enumeration, seven of 13; mitogen responsiveness of phytohemagglutinin, 10 of 11; concanavalin A, 10 of 11; pokeweed mitogen, 10 of 11; B-cell responsiveness by anti-immunoglobulin immunobead stimulation, two of six; responsiveness to streptolysin O antigen, four of seven; mixed-lymphocyte reaction, six of seven; natural killer cell activity, six of eight. Specific immunity to Epstein-Barr virus was measured by complement-independent, antibody-mediated virus neutralization (mean index for HCL patients being 56% of control value) and complement-dependent virus neutralization (98% of control value). We concluded that, in spite of depressed levels of immune responses measured with general, cellular assays, functional levels of complement-dependent virus-neutralizing antibody were present in these HCL patients.

Antibodies, Viral↗
PubMed1984

Demonstration of p35 in hairy cell leukemia of Japanese patients.

Using SDS polyacrylamide gel electrophoresis (SDS-PAGE), several coworkers isolated a unique membrane protein that they named p35 from hairy cells of white patients with hairy cell leukemia. In the current study using a similar technique, p35 was identified in hairy cells from 2 of 4 Japanese patients with hairy cell leukemia. Further, p35 was immunoprecipitated from the leukemic membrane proteins of one of these two Japanese patients with an anti-hairy cell serum prepared against hairy cells of a typical white patient. Because both Japanese and white patients share the unique membrane antigen, it is proposed that the Japanese have the hairy cell leukemia as whites despite some differences in laboratory features.

Antigens, Neoplasm↗
PubMed1984

Reduced response of scleroderma fibroblasts to fibroblast growth factor.

Reactivity of scleroderma fibroblasts to lymphoid cell-derived fibroblast growth factor (FGF) was assessed in this study. The fibroblasts from the sclerotic lesion failed to respond to FGF, whereas those from scleroedematous lesions responded equally to normal fibroblast. Response of the fibroblast from sclerotic lesion was also lower than that of the fibroblast from mature scar. Fibroblasts obtained from three different layers of healthy skin, papillary dermis, reticular dermis, and reticular-subcutaneous layer, responded equally to FGF, whereas the fibroblast of reticular dermis from sclerotic lesion failed to respond to FGF. It is suggested that the fibroblast of reticular dermis in scleroderma is variously activated by some unknown factors, so that they do not have enough reserve to respond to further stimuli.

Animals↗
PubMed1984

Histochemical demonstration of endogenous estrogen in breast carcinomas: biochemical and clinical correlation.

In a study of 277 patients with breast carcinomas, the PAP immunoperoxidase method for demonstrating endogenous estrogen was correlated with the sucrose density gradient (SDG) assay and with histologic and clinical features. The results from the PAP method and SDG assay agreed in 59 of 84 patients (82.1%) on whom both methods were performed. Histologically, the PAP method was positive in 7 of 7 patients with non-invasive carcinomas, in 164 of 233 patients (70.4%) with common invasive ductal carcinoma, and in 21 of 22 of those with special histological types of of invasive carcinomas not including Paget's disease, medullary or apocrine carcinoma, where only 5 of 14 were positive. Clinically, 15 of 18 patients with positive endogenous estrogen showed a response to endocrine therapy as opposed to 1 of 9 patients with a negative endogenous estrogen. The mean survival was 31.2 and 15.6 months, respectively for patients with positive and negative endogenous estrogen. Remission for longer than 2 years was seen more often in patients with positive endogenous estrogen. These results suggest a clinical utility of the present PAP method which, therefore, deserves a further trial as an alternative to histochemical methods aiming at the estrogen receptors.

Breast Neoplasms↗
PubMed1984

Induction of hapten-specific lymphoid cell proliferation by liposome-carrying molecules from haptenated epidermal cells in contact sensitivity.

Liposomes containing the extract of trinitrophenylated (TNP) epidermal cells stimulated lymph node cells from TNCB-sensitized mice effectively. Optimal stimulation was achieved by the liposome containing 0.06 microgram of the extract of TNP epidermal cells/microgram of phospholipid at a concentration of 20 micrograms phospholipid/ml. The response was hapten-specific and macrophage-dependent. UV irradiation of the epidermal cells abolished their ability to stimulate the lymph node cells. Furthermore, the liposomes containing the extract of TNP epidermal cells treated with anti-Ia and complement failed to stimulate the lymph node cells. The liposomes recovered their reactivity when nonhaptenated Ia antigen-rich epidermal extract was added. Taken together, it is likely that haptenated molecules and Ia antigen on the liposome stimulated T-lymphocytes in the presence of macrophages.

Animals↗