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Biomedical subjects

I Katayama

Publications and source records attributed to I Katayama.

At least 235 records · Page 13Linked to original sources
PubMed1989

Annular erythema: a possible association with primary Sjögren's syndrome.

In four patients with primary Sjögren's syndrome a distinct annular erythema developed, which was characterized by a wide, elevated border (which can be likened to a doughnut ring) and central pallor. Histologically, there was a coat sleeve-like infiltration of lymphocytes around blood vessels and nuclear debris in the connective tissue. Vasculitis or epidermal changes suggestive of lupus erythematosus were not observed, and there was no immunoglobulin deposition along the basement membrane zone. This annular erythema may be a cutaneous manifestation of Sjögren's syndrome.

Adult↗
PubMed1989

Neonatal lupus erythematosus with a high anticardiolipin antibody titer. Unusual variant of neonatal lupus erythematosus or early-onset systemic lupus erythematosus?

A malar rash associated with severe gastrointestinal manifestations developed in a 4-month-old baby 3 months after a normal delivery. Serum complement and IgA levels were low during the active phase of the illness. An increased anticardiolipin antibody titer was demonstrated at the onset of disease and persisted for more than 6 months, at which time the skin and gastrointestinal manifestations subsided. The baby's mother, who had no symptoms, had an elevated Ro (SS-A) antibody titer and a moderately elevated anticardiolipin antibody titer.

Antibodies, Antinuclear↗
PubMed1989

Annular erythema associated with primary Sjögren syndrome: analysis of T cell subsets in cutaneous infiltrates.

Immunohistochemical analysis was performed on the annular erythema associated with Sjögren syndrome. This type of annular erythema is characterized by a doughnutlike appearance with an elevated border and central pallor; it is distinct from subacute cutaneous lupus erythematosus. Histologically this erythema is characterized by coat sleeve-like infiltration of lymphocytes around blood vessels and by nuclear debris in the connective tissue. Vasculitis or epidermal changes suggestive of lupus erythematosus were not observed in any of the cases, although immunoglobulin or complement deposition along the basement membrane zone and focal liquefaction degeneration of the basal layer in involved skin were seen in some cases. Major dermal infiltrates consisted primarily of CD4+ and 4B4+ lymphocytes.

Adult↗
PubMed1989

Tumoral calcinosis in scleroderma.

A 36-year-old female patient with scleroderma/Sjögren's syndrome developed multiple cystic tumors on the dorsal aspect of her left hand, right elbow, and left shoulder joint two years after the onset of scleroderma. Histologically, amorphous eosinophilic substances located in subcutaneous tissue showed a strong positive reaction to PTAH and rosindole stain, and focal positive reaction to Von Kossa stain. Rheumatoid rice body like substances with chalky fluid were discharged from tumoral lesions. From these results, this case was diagnosed as tumoral calcinosis secondary to connective tissue degeneration due to the pathogenetic mechanism underlying scleroderma/Sjögren's syndrome.

Adult↗
PubMed1989

Drug-induced chronic pigmented purpura.

A close correlation between purpuric reaction and drugs was observed in seven cases of chronic pigmented purpura. The patients developed purpuric lesions after taking certain drugs for more than 3 years, were thiamine propyldisulfide in 2 cases, and chlordiazepoxide in 1 case. The purpuric lesions stopped recurring after removal of the drugs in the rest of the cases. It is suggested that drugs are among the etiological factors in chronic pigmented purpura.

Aged↗
PubMed1989

[Clinical studies of skin manifestations of Sjögren's syndrome].

The skin manifestations of the patients with definitive Sjögren's syndrome were clinically studied. Chief complaints at the first consultation included annular erythema, pernio-like erythema, Raynaud's phenomenon, purpura, and malar erythema. Drug eruptions and xerotic eczema were also occasionally observed during the course. However, annular erythema, pernio-like erythema, drug eruptions, purpura, facial pigmented patches, and erythema nodosum were observed much more frequently in patients with primary Sjögren's syndrome. These skin manifestations might be useful clues for the diagnosis of Sjögren's syndrome in dermatological fields.

Adolescent↗
PubMed1989

[A case of meningoencephalitis caused by persistent Epstein-Barr (E-B) virus infection].

A 44-year-old man had several episodes of tingling sensation in his lower extremities, head and face over 1 year and presented mental disturbance 2 months prior to admission. He additionally suffered from dysuria and acute onset of gait disturbance 18 days before admission. Physical and neurological examination revealed marked splenomegaly, stupor, abnormal behavior, spastic tetraparesis and sphincter disturbances, and meningoencephalitis was suspected. There was lymphocytosis in peripheral blood, some of which showed atypical morphology. CSF examination revealed increased protein content and mononuclear pleocytosis. The titers of antibodies against E-B virus were elevated as follows; VCA IgM (X320), VCA IgG (X20,480), EA (X10,240) and EBNA (X10) in serum, and VCA IgM (X4), VCA IgG (X160), EA (X40) and EBNA (less than 1) in CSF. CT and MRI examination revealed ring enhanced lesion adjacent to left lateral ventricle with surrounding diffuse edema. Administration of intravenous glycerol and oral prednisolone induced substantial improvement in sensory, mental and sphincter disturbances and brain CT findings but not in splenomegaly and pyramidal tract signs. Antibody titer against VCA IgM also decreased. After withdrawal of prednisolone, CSF and CT findings worsened, and the antibody titer became elevated again, and CSF and CT findings improved by readministration of prednisolone. From the above signs and laboratory data, especially continuous elevation of antibody titer against E-B VCA IgM for as long as 1 year, this case was considered to be a meningoencephalitis caused by persistent E-B virus infection.

Adult↗
PubMed1989

[Clinical analysis of anti-cardiolipin antibody positive patients with systemic lupus erythematosus].

We have analyzed the relationship between anti-cardiolipin antibody titer and manifestations in 68 patients with systemic lupus erythematosus (SLE), 25 patients with progressive systemic sclerosis (PSS), 37 patients with Sjögren's syndrome and 16 patients with anaphylactoid purpura. Elevated anti-cardiolipin antibody titer was observed in SLE and Sjögren's syndrome. Clinical manifestations correlated with elevated anti-cardiolipin antibody titer included discoid lesion, thrombotic lesion, thrombocytopenia, elevated titer of ds-DNA antibodies, lower serum CPK level, and liver dysfunctions. Anti-cardiolipin antibody titer also correlated with the score of diagnostic criteria for SLE and the history of corticosteroid therapy. These results suggested that anti-cardiolipin antibody positive SLE patients are much more prone to develop thrombotic lesions and that cell bound antibody might play some role for the induction of vascular injury and thrombocytopenia in SLE.

Antibodies↗
PubMed1989

[Clinical studies of 15 cases of progressive systemic sclerosis (PSS) associated with positive proteinuria and membranous glomerulonephritis].

In this study, we demonstrated that the patients with PSS who develop proteinuria during the course are much more prone to develop lung fibrosis, telangiectasia, serositis and esophageal hypomotility. They also exhibited positive LE cell phenomenon, lupus band test, thrombocytopenia and leukopenia. The mortality rate is significantly higher in proteinuria positive patients and abnormal clinical data described above seem to be the risk factors for the development of renal involvement in PSS.

Adult↗
PubMed1989

[Anthralin therapy of psoriasis--a retrospective study of 39 cases].

Anthralin therapy was used in 39 cases with psoriasis, 31 cases with large plaque type and 8 cases with small plaque type. The therapy was performed in 2 ways with 0.05-2% anthralin ointment: short contact therapy and long contact therapy. Both therapies worked equally well on psoriasis. Improvement was observed in 26 cases (67%); 7 cases did not respond to the anthralin therapy. In 6 cases it was difficult to assess its effect. The large plaque type of psoriasis responded better than the small plaque type and showed a much longer remission period. Of the improved cases with large plaque type, 45% had remission periods longer than 6 months. Skin irritation (29 cases) and pigmentation (20 cases) were the side effects of anthralin therapy. However, those side effects were avoided by starting the therapy with a lower concentration of anthralin ointment and increasing the concentration gradually. Short contact therapy enabled us to apply the ointment in an outpatient clinic. It is suggested that anthralin therapy should be applied more frequently to psoriasis.

Adolescent↗
PubMed1989

The effect of alpha-interferon on the liver in a patient with hairy cell leukemia: light and electron microscopic studies.

A daily dose of 3 x 10(6) or 6 x 10(6) units of alpha-interferon was given during two 4- to 6-month periods to a 65-yr-old male patient with hairy cell leukemia, reducing splenomegaly and decreasing the number of hairy cells. Liver biopsy specimens taken during treatment revealed predominantly decreased hairy cell infiltration in the dilated sinusoids and enlarged or vacuolar nuclei of hepatocytes, compared with those in the liver before treatment. The ultrastructure of hepatocytes in specimens taken during treatment showed cytoplasmic vacuoles, weakly stained glycogen particles, and conspicuously decreased endoplasmic reticulum. Liver tests revealed decreased serum cholinesterase and total cholesterol levels in the early stage of treatment, low levels of total protein and albumin during treatment, and a very low value in the [13C]aminopyrine breath test. No clinical reports have been made on the decreased microsomal function during treatment with interferon. alpha-Interferon damaged the endoplasmic reticulum of hepatocytes, although it was effective for the reduction of hairy cells in the liver of hairy cell leukemia.

Aged↗
PubMed1988

Congenital neuroblastoma presenting as a paratesticular tumor.

A 1-month-old male newborn was operated upon for a scrotal tumor that was localized outside of the testis. Histological diagnosis was neuroblastoma. Although neuroblastoma often may present as metastatic disease when first seen, this case is unique in that an undetected adrenal neuroblastoma presented as a paratesticular tumor immediately after birth.

Adrenal Gland Neoplasms↗
PubMed1988

Melanotic schwannoma arising in the sympathetic ganglion.

A case of melanotic schwannoma, the 28th reported in the literature and the second to arise in the sympathetic ganglion, was reported in a 39-year-old man who remains free of recurrence or metastasis since removal of the tumor. In common with earlier benign melanotic schwannomas, its ultrastructural study revealed well-developed contiguous external lamina as opposed to absent or only minimally developed external lamina seen in malignant melanotic schwannomas. This emphasizes the use of electron microscopy in the diagnosis of this tumor. The literature yields only nine melanotic tumors (including one malignant melanotic schwannoma) arising in the sympathetic nervous system; all nine tumors had a malignant clinical course. Therefore, the present case represents the first "benign" tumor among ten melanotic tumors, and the second among 28 melanotic schwannomas to arise in the sympathetic nervous system.

Adult↗
PubMed1988

Specific skin lesions as the presenting symptom of hairy cell leukemia.

A 68-year-old Japanese man with a chief complaint of eczema-like dermatosis was diagnosed as having B-cell hairy cell leukemia (HCL) by demonstration of hairy cells in the skin lesions as well as in blood and bone marrow. He was treated with alpha-interferon, resulting in disappearance of skin lesions and reduction of his massive splenomegaly from 18 to 5 cm in about 14 months. Although specific skin lesions in HCL, shown by a review of the literature to occur in about 8% of cases, are not as uncommon as generally assumed, it is rare for HCL to present with specific skin lesions, the present case being only the second of its type mentioned in the literature.

Aged↗