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I I Dedov

Publications and source records attributed to I I Dedov.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

[Genetic and immunologic aspects of type 1 diabetes mellitus].

Prediction of type 1 diabetes mellitus (IDDM) and its identification in preclinical period is one of the central problems in modern medicine. They are based comprehensive genetic, immunologic and metabolic evaluations. We observed four hundred seven first-degree relatives of patients with IDDM (240 families in which one of the children or one of the parents had IDDM) have been included in the study. The study of HLA-DQA1, HLA-DQB1 polymorphic alleles and DRB1 genes and their combinations. The genetic study included searching HLA loci (HLA-DQA1, HLA-DQB1 polymorphic alleles and DRB1 genes) loci. To evaluate the genetic risk two approaches we used: first--carrying predisposing HLA-DQ alleles and DRB1-genes and it's combination (mainly associated in Russian population was DRB1*04-DQB1*0302, DRB1*04-DQA1*0301, DQA1*0301-DQB1*0302, DQA1*0301-DQB1*0302 and four susceptible alleles in A- and B- chains (Asp 57-, Arg 52+)) and second--IBD (identity by descent), in Russian population HLA-identical for 2 haplotypes sibs had risk of development of IDDM of 18%, for 1 haplotype--3%, for 0 haplotype-0.9%. The antibodies (ICA, IAA) prevalence rate has not depended on availability of predisposing HLA-DQ alleles and DRB1-genes and haploidentity of normal sibs and sibs with IDDM. However, GADA prevalence rate in groups having high predisposed alleles has been noticed as significantly higher (28.6%) comparing with 7.7% in groups that had no predisposing alleles (p < 0.05). The comparison of antibodies prevalence rate to sibs HLA-identity has shown the significant increase or GADA prevalence rate in group of siblings identical for one haplotype comparing with non-identical sibs (27.3% and 0% respectively, p < 0.001).

Alleles↗
PubMedDate not supplied

[Heterogeneity of immunoreactive prolactin in hyperprolactinemia of various origin].

Study of molecular heterogeneity of immunoreactive prolactin in patients with macro- and microprolactinomas and idiopathic hyperprolactinemia has shown heterogeneity of the total blood immunoreactive prolactin pool in all the examined patients. This pool included three basic forms with molecular masses about 23, 50, and over 100 kD (23K-, 50K-, 100K-prolactin), whose ratios essentially differed in individual patients. Physiologically the most active monomeric 23K form of prolactin predominated in the blood of patients with hyperprolactinemia due to hypophyseal micro- and macroadenomas, parallelled by manifest signs of galactorrhea and hypogonadism; the content of this form may reach 95% of the total immunoreactive hormone. Patients with hyperprolactinemia of obscure origin present with quite the contrary ratio of prolactin immunoreactive forms with the predominance of high-molecular 100K form of the hormone, whose share may reach 80-90%. Such cases of hyperprolactinemia may be associated with the absence of clear-cut clinical manifestations, including such as galactorrhea and menstrual cycle disorders, and with inefficacy of traditional therapy. Such cases were tentatively classified as 'the high-molecular prolactin syndrome' and need further research.

Adenoma↗
PubMedDate not supplied

[Lipid peroxidation and antioxidant enzymatic defense in patients with newly detected insulin-dependent diabetes mellitus].

Studies of lipid peroxidation and antioxidant enzymic defense in red cell membranes in 23 patients with newly detected insulin-dependent diabetes mellitus have revealed a statistically significant (2-fold) elevation of malonic dialdehyde lipid peroxidation products and a trend to a rise in the levels of lipid peroxides. This is parallelled by a certain overstrain of the cellular antioxidant defense system. The authors discuss the usefulness of administering antioxidant therapy at the onset of the disease in order to prevent the toxic injury of beta-cells and vascular endothelium cells by lipid peroxidation products.

Adolescent↗
PubMedDate not supplied

[Diffuse toxic goiter].

Diffuse toxic goiter is a common disease of the thyroid gland. As organospecific autoimmune condition the disease is not infrequently combined with endocrine ophthalmopathy and in this connection a more precise preparation of the patients to surgery is found to be mandatory. Elderly persons demonstrate atypical patterns of the disease course (insignificant enlargement of the gland, manifest depression, isolated cardial disorders without other symptoms of thyrotoxicosis, resistance to thyrostatic treatment). The patients need a life-long dispensary follow-up as diffuse toxic goiter is a condition of a relapsing type.

Aged↗
PubMedDate not supplied

[Osteopathy in diabetic foot syndrome].

Morphological characteristics of bone tissues were studied in the feet of patients with diabetes mellitus type 1 and 2 (DM1 and DM2). Osteoblasts and osteoclasts prevalence, the presence of collagen type III in the composition of newly formed bone were characteristic for DM1. Osteocytes prevalence and abundant granulation tissue in newly formed bone was a feature of DM2. The analysis of bone tissue resorption suggests that lacunar osteoclastic resorpsion is the main type in DM1 while periosteocytic osteolysis and smooth resorption are typical for DM2. Thus, osteolysis genesis and synthesis of bone tissue in DM1 and DM2 may be different.

Adult↗
PubMedDate not supplied

[Change of the complement level in patients with insulin-dependent diabetes mellitus in the course of intensified insulin therapy].

Intensified insulin therapy in patients with type I diabetes mellitus is accompanied by a decrease in a total daily dose of insulin and the activity of the first 5 components of the classical pathway and CH50. A decrease in function of the first 5 components of the complement against a background of intensified insulin therapy can serve as a positive prognostic criterion of stabilization of development of diabetic angiopathies.

Adolescent↗
PubMedDate not supplied

[Probability of an association between HLA- and DR-antigens in nuclear families of patients with insulin-dependent diabetes mellitus].

Insulin dependent diabetes mellitus (IDDM) is known to associate with various antigens and alleles of the HLA-system: DR3, DR4, and DQ-determinants. However penetration of the HLA-genes, predisposing to disease, is low, suggesting a possible role of additional genes outside the HLA-system in IDDM development. Among such genes there can be a group of heavy chain Ig genes (the Gm-system). The frequency of antigens of the Gm-system C1m(1) and C1m(2) and antigens of loci A, B, C and DR of the HLA-system was investigated in 92 Russians divided into 3 groups: 1 - IDDM patients from nuclear families (n = 35); 2 - their relatives of the 1st degree of kinship (n = 34); 3 - a random sampling (n = 23). The results obtained by A. A. Lopatenok and O. S. Budyakov (1973) were used as control data. No significant difference (p greater than 0.05) was found while comparing the frequency of Gm-phenotypes in IDDM patients from nuclear families with DR 4/X and in IDDM patients from nuclear families with another DR-phenotype, nor any significant difference was noted while comparing the frequency of Gm-phenotypes in IDDM patients from nuclear families and in patients from a random sampling with the HLA-phenotype DR 4/X. Thus the relationship of the Gm-system with IDDM through interrelationship with the HLA-DR-genes was undetectable. A conclusion was made that factors of the Gm-system played no significant role in predisposition to IDDM and could not be used as its genetic markers.

Adolescent↗
PubMedDate not supplied

[Dynamics of disorders of cellular and humoral immunity parameters in patients with insulin-dependent diabetes mellitus].

Analysis of immunocompetent cell subsets in peripheral blood of patients with insulin dependent diabetes mellitus (IDDM) and the determination of sICA-autoantibodies in their sera were performed by flow rate cytometry and compared to healthy donors and patients with noninsulin-dependent diabetes mellitus (NIDDM). It was shown that newly diagnosed IDDM was characterized by predominant disturbances of humoral immunity, and disease progression was mainly accompanied by cellular immunity disturbances. Exogenous insulin was one of the causes of such disturbances. A tendency to normalization of cellular rather than humoral immunity was observed after the onset of human monocompetent therapy of IDDM patients. It is likely that the appearance in the peripheral blood of activated T-lymphocytes accompanied by sICA-autoantibodies and increased mature B-lymphocytes and NK-cells counts corresponds to increased ADCC against pancreatic beta cells in IDDM development.

Animals↗
PubMedDate not supplied

[Nosological structure of thyroid nodular lesions by autopsy data].

629 autopsies were studied to elucidate nosological structure of thyroid nodular lesions. The material was epidemiologically representative in relation to older Moscow population. Colloid stroma with proliferation, atrophic and scarred alteration (total 80.3% cases) prevailed among nodular lesions more than 1 cm in diameter followed by adenomas (11.6%), carcinoma (5.8%) and autoimmune thyroiditis (2.3%). It is shown that alcoholic disease is associated with thyroid atrophy and low risk of goiter alteration.

Adult↗
PubMedDate not supplied

[Some parameters of endocrine function in patients with hemophilia].

The hormonal status of 40 patients with hemophilia A and in 5 patients with hemophilia B was investigated by radioimmunoassay during exacerbation against a background of the hemorrhagic syndrome and in remission. A decrease in the plasma levels of cortisol, T3, insulin and high levels of ACTH and estradiol were observed in patients with a severe type hemophilia during exacerbation. Remission was characterized by an increase in the STH level and a decrease in the ACTH level. The severity of hemorrhagic manifestations was determined not only by a degree of a decrease in the level of blood factor VIII but also by a degree of a decrease in the levels of cortisol, T3 and insulin. Hormonal drugs (prednisolone, thyroidin and methyl androstenediol) were also included in multimodality therapy of hemophilia.

Adolescent↗
PubMedDate not supplied

[Use of lysenyl-forte and methergoline in the therapy of hyperprolactinemic hypogonadism].

The paper is concerned with a study of the effectiveness of lysenyl-forte (Hemapol, Czechoslovakia) and methergoline (Carlo Erba, Italy) for therapy of patients with different types of hyperprolactinemic hypogonadism. Altogether 49 patients were investigated, of them 33 received lysenyl-forte at a dose of 0.6 mg/day and 16-methergoline at a dose of 12 mg/day for 3 months. A degree of galactorrhea, a menstrual cycle and the blood level of prolactin were assessed before and after therapy. A prolactin inhibiting effect of both drugs comparable with that of bromocriptine was noted. However a clinical effect and good tolerance were more frequently observed in this sampling in lysenyl therapy.

Adult↗