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Biomedical subjects

I I Dedov

Publications and source records attributed to I I Dedov.

At least 199 records · Page 11Linked to original sources
PubMedDate not supplied

Ultrastructural changes in cells of transplanted mammary gland carcinoma at different stages of their development.

The process of development and death of cells of primary mammary gland carcinoma was studied in rats in various hormonal situations, using electron microscopy. It was shown that the death of cancer cells is not preceded by their differential and specific functioning, which is postulated by certain authors. The problem of hormonal induction of the phenomenon of differentiation of malignantly degenerated cells is discussed.

Animals↗
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[Attempt to use the genetically engineered growth hormone SAIZEN in children with somatotropic insufficiency: results of clinical trials in Russia].

The efficacy and safety of SAISEN, a recombinant human growth hormone obtained from mammalian cells, was tested in children with hypophyseal nanism. The treatment duration was 1 year. The results indicate that SAISEN (ARES-SERONO) is a highly effective and safe preparation of growth hormone, noticeably stimulating the growth rate both in previously untreated children with somatotropic insufficiency, and in those previously treated with STH preparations. Therapy with SAISEN was not associated with any side effects, as shown by both clinical and laboratory data.

Child↗
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[Computed tomographic diagnosis of substernal goiter].

The authors analyze the results of computer-aided tomographic (CAT) diagnosis in 25 patients with restrosternal goiter. They claim that CAT is a method of choice in the preoperative diagnosis of retrosternal goiter, permitting the solution of a problem on the volume of surgical intervention and of the type of anesthesia. CAT helps specify the site, size, and dissemination of goiter beyond the sternum and assess its relations with the adjacent organs and tissues.

Adult↗
PubMedDate not supplied

[Dopaminergic regulation of the hypothalamo-hypophyseal-adrenal system in Itsenko-Cushing disease].

Nineteen patients with Itsenko-Cushing's disease aged 13 to 18 were examined during an active stage of the disease and during a remission after proton exposure of the hypophysis. Nine normal subjects were controls. Adenohypophyseal tropic hormones and hydrocortisone were radioimmunoassayed before and after administration of nakom, a dopaminergic agent. ACTH, hydrocortisone, TTH, parlodel secretion were found decreased and LH increased in patients with Itsenko-Cushing's disease, and no STH increase characteristic of normal subjects was observed. During remission after proton therapy adenohypophyseal tropic hormones and hydrocortisone secretion normalized in response to nakom. Recovery of STH secretion was observed, but not in all patients, this being confirmed by the absence of a normal somatotropin response in nakom test in 26.32% of patients.

Adolescent↗
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[Age-related features of neurohumoral regulation of somatotropic hormone secretion].

Experiments with primary cultures demonstrated a stimulating effect of TRF on somatotropic hormone (STH) secretion by hypophyseocytes of neonatal but not adult rats and a reduced reactivity of neonatal somatotrophs to the inhibitory effect of somatostatin during short-term incubation. No noticeable serotonin effect on STH release from hypophyseal cells of animals of various ages was observed. During prolonged (24 h) incubation a weak inhibitory effect of bromocriptine and melatonin on STH secretion by pituitary cells of neonatal but not adult rats was observed. These results permit us propose a similarity of the functional characteristics of neonatal pituitary somatotrophs to somatomammotroph properties.

Animals↗
PubMedDate not supplied

[Parameters of cellular and humoral immunity in patients with diabetes mellitus in the early stages of disease development; experience in treatment with the immunosuppressant azathioprine].

A total of 40 patients with type I diabetes mellitus, in whom the disease was diagnosed 1 to 12 months previously, were examined. An imbalance between the T and B cellular components of the immunity was found in the patients with the early stages of the disease, as was an elevated titer of the complement C1 component as against the reference group. The degree of the immunologic shifts was in direct correlation with the HLA A9 antigen expression, this relationship being the most marked in cases with the HLA DR3 and DR4. The incidence of these antigens expression was significantly higher in the patients with marked immunity shifts, than in those with negligible immunity changes. Therapy with an immunosuppressant azathioprine was associated with a noticeable reduction of the initially elevated cellular immunity parameters (total T and B lymphocyte counts, T helpers-inductors, DR carriers) and a trend towards a reduction of all the components and total activity of the classical route of the complement activation predominantly at the expense of the C1 and C5 components. The efficacy of this drug in therapy of new cases of insulin-dependent diabetes mellitus was confirmed, and the indisputable relationship between the efficacy of immunity suppression, that helped achieve a clinical remission, and the disease duration, was demonstrated. Monitoring of the cellular and humoral immunity parameters, of the activity of the classical route of the complement activation permitted an indirect judgement on the usefulness of immunity suppression for the correction of immunity disorders as factors contributing to the development of microvascular disturbances in insulin-dependent diabetes mellitus.

Adolescent↗
PubMedDate not supplied

[Comparative assessment of conservative therapy methods in patients with the diabetic foot syndrome].

Fifty patients with types I and II diabetes complicated by the diabetic foot syndrome were examined. The patients were divided into two groups: Group I patients were administered x-ray therapy of the feet and shins, group 2 ones were treated by angioprotectors and antiaggregants. Complaints and objective data, findings of ultrasonic examination of the lower limb vessels and biothesiometry, x-ray picture before and 6 months after the treatment were assessed. 36 normal subjects made up the control group. The authors emphasize a marked effect of x-ray therapy as against drug treatment.

Adolescent↗
PubMedDate not supplied

[Determination of autoantibodies to pancreatic beta-cells, non-islet endocrine cells and fibroblasts in patients with newly detected diabetes mellitus].

The clinical onset of insulin-dependent diabetes (IDD) is characterized by the onset of circulation of autoantibodies to beta-cells. Thirty-three newly detected IDD patients and 14 newly detected patients with noninsulin-dependent diabetes mellitus were examined for autoantibodies to antigen P 64-69, to surface antigen of islet cells, to thyrocyte microsomal fraction, thyroglobulin, hypophysis, fibroblasts; the levels of circulating immune complexes were measured as well. IDD debut was found associated with the appearance of antibodies to pancreatic islet cells, thyroid, thyroglobulin, hypophysis, fibroblasts, this indicating a polyclonal activation of the immunity system. A relationship was revealed between antifibroblast antibody and anti-islet-cell antibody. Antihypophyseal antibodies were detected in 43% of patients with noninsulin dependent diabetes. Nine per cent of IDD patients and 24% of patients with noninsulin dependent condition were negative in the tests.

Adolescent↗
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[Use of glurenorm in patients with non-insulin-dependent diabetes mellitus and liver diseases].

Due to its pharmacokinetics, glurenorm (95% of the drug metabolite is withdrawn from the body with the bile) is widely used in patients with non-insulin-dependent diabetes mellitus (NIDDM) with disturbed renal function. It seemed that, bearing in mind the relationship between glurenorm elimination and liver function, this drug use in patients with NIDDM patients with liver diseases should be restricted. The aim of the present research was to study glurenorm effect on liver function. Eighteen patients with NIDDM and liver diseases, administered glurenorm, were followed up. No clinical or laboratory deterioration on the part of the liver were detected over the course of follow-up. The results evidence no negative effects of glurenorm on the kidneys or liver, therefore the drug may be used in the treatment of NIDDM patients with liver abnormalities.

Adult↗
PubMedDate not supplied

[Effectiveness of an intensive treatment and training program for patients with type I diabetes mellitus].

The authors analyze the results of comprehensive, prospective, controlled investigation of the program for intensive care and training of 121 patients with insulin-dependent diabetes mellitus (IDDM). The basic principles of the program are training on a team's basis, intensive insulin therapy, auto-monitoring of metabolism, and liberal diet. The results demonstrate that glycemia level approaching the normal may be attained and maintained in the majority of patients without increasing the risk of grave hypoglycemia, cases with severe diabetic ketoacidosis may be eliminated, and periods of temporary invalidity of patients reduced by 7-10 times. The selected training program was equally effective for patients of various age groups and levels of education, as well as for patients with "labile" diabetes. Results of treatment did not depend on the type of insulin preparations used. The authors come to a conclusion on a higher efficacy of new strategy of IDDM treatment in comparison with the traditional approaches.

Adolescent↗
PubMedDate not supplied

[Analysis of the quality of primary therapeutic-preventive care rendered to patients with type I diabetes mellitus].

A prospective follow-up of a random sample of patients with insulin-dependent diabetes mellitus revealed a marked decompensation of carbohydrate metabolism in 98% of the examinees, a high incidence of diabetic ketoacidosis, a long duration of temporary invalidity, and poor adherence of patients to medical recommendations. Assessment of primary health care rendered to patients with type I diabetes at district outpatient clinics of Moscow demonstrated its poor efficacy and a necessity to improve the level of specialized diabetologic care.

Adolescent↗