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Biomedical subjects

I Holme

Publications and source records attributed to I Holme.

144 records · Page 8Linked to original sources
PubMed1978

Serum triglycerides and serum uric acid in untreated and thiazide-treated patients with mild hypertension. The Oslo study.

Levels of serum lipids, uric acid and body weight are reported from a controlled trial of drug treatment of middle-aged men with uncomplicated mild hypertension. The results come from 300 men after three years of follow up; 150 men in the treatment group and 150 men in the control group. The treatment has been standardized starting with hydrochlorothiazide alone and adding alpha methyldopa when necessary. In case of side effects, alpha methyldopa was replaced with propranolol. Pretreatment results demonstrated a strong covariation among body weight, uric acid and triglycerides. In the entire treatment group, there was no significant change in triglycerides after three years (increase from 1.85 to 2.02 mM/liter, P greater than 0.05). Cholesterol was also unchanged. Further analysis showed that certain patients reacted with an increase in triglycerides during treatment: those prone to a distinct increase in uric acid and those gaining weight. Those who needed combination therapy (having the highest pretreatment blood pressure) showed most of the increase in triglyceride and uric acid. In the group treated with hydrochlorothiazide alone, the triglycerides were unchanged. However, those selected from this group with a distinct increase in uric acid also showed an increase in triglycerides. The treatment increased the pretreatment positive correlation between uric acid and triglycerides.

Adult↗
PubMed1978

The association between blood pressure and serum cholesterol in healthy men: the Oslo study.

The association between serum cholesterol and blood pressure (BP) has been studied in 16 525 men. The study reveals that these Oslo men in their forties present with a serum cholesterol value which is on average 0.71 mmol/l (27.4 mg/100 ml) higher at diastolic BP greater than 110 mmHg than at BP less than 70 mmHg. According to earlier studies in Oslo, this cholesterol difference alone imparts a 10-year myocardial infarction morbidity difference of 25--30%. These findings might be of practical importance for epidemiological studies and for preventive measures against the two factors. The influence of other variables on the association between blood pressure and cholesterol has been studied in a multivariate analysis. Of these variables, only body mass index and serum triglycerides significantly influence the relationship between blood pressure and cholesterol, whereas age, cigarette smoking, non-fasting blood sugar, season, socioeconomic status, and physical activity at work and leisure do not influence the correlation.

Adult↗
PubMed1977

Coronary risk factors in various occupational groups: the Oslo study.

Coronary risk factors (CRF) have been recorded for nearly 15 000 men aged between 40 and 49 living in Oslo in 1972. These data are matched with the 1970 census data for Norway so as to analyse CRF within various occupational groups. A fairly good agreement between mortality statistics for Norway and CRF was found in many occupations. For instance, persons in pedagogical work have low total mortality rates consistent with their low coronary risk factors. Taxi and busdrivers, on the other hand, have been reported to have mortality rates from lung cancer and coronary heart disease consistent with their high smoking prevalence, serum triglycerides, and cholesterol levels.

Adult↗
PubMed1976

Coronary risk factors and socioeconomic status. The Oslo study.

Coronary heart-disease (C.H.D.) had been reviewed as a "manager's disease". However, deaths from C.H.D. are now said to be more common in groups from the lower social classes than in those of higher socioeconomic status. We have examined wheather these differences in C.H.D. mortality can be explained by differences in the conventional risk factors for C.H.D.

Adult↗
PubMed1976

Five-year mortality in the city of Bergen, Norway, according to age, sex and blood pressure.

The City of Bergen was covered by a Mass Miniature Radiology Survey in 1963-64. On the initiative of the University of Bergen, examinations of BP were included. The initial survey has been reported previously (1). This analysis concerns the relationship between the 5 1/4-year cause-specific mortality and BP. Non-attenders have excess mortality in relation to attenders and this is mostly explained by a generally high mortality among bedridden people. The age-specific total mortality shows a clear pattern of a general increase with increasing BP. At high systolic BP levels, the 5-year mortality is independent of whether the age is 45 or 75. The systolic age-adjusted curve for males increases quite linearly, while the diastolic curve is more U-shaped. Thus, when comparing the predictive power of BP, allowance must be made for this fact. Using a second order polynomial prediction function, this conclusion is reversed. The mortality from cerebral stroke shows a dramatic increase with increasing BP. The diastolic curve shows a bend-off for high values, above 110 mmHg. This may be due to the offer of treatment which such patients received after the screening. Also the CHD mortality curve flattens for high BP values, especially for diastolic BP.

Adolescent↗
PubMed1976

The intercorrelation of serum cholesterol, cigarette smoking and body weight. The Oslo Study.

A screening for coronary risk factors in 18 000 Oslo men yielded 16 525 "healthy" men, aged 20-49. The intercorrelation of serum cholesterol, body weight and cigarette smoking was found to be more pronounced than described in other studies. Increasing daily exposure to cigarette smoke in the order: never-smoker, ex-smoker, non-inhaling smoker, inhaling smoker and present non-filter smoker, was parallelled by increasing cholesterol levels, but not by increasing body weight. Daily cigarette-smokers had lower body weight and higher serum cholesterol values than never-cigarette-smokers, with the exception of the 20+ cigarette-smokers who had higher serum cholesterol values and body weight than the never-cigarette-smokers. As regards ex-cigarette-smokers, both body weight and serum cholesterol tended to increase with the number of cigarettes smoked before quitting. Possible explanations of these findings are discussed.

Adult↗
PubMed1975

The effect of anesthesia on intraoperative and postoperative bleeding during abdominal prostatectomies: a comparison of neurolept anesthesia, halothane anesthesia and epidural anesthesia.

Intraoperative blood loss was measured during abdominal prostatectomies in 213 patients anesthetized with neurolept anesthesia, halothane anesthesia and epidural anesthesia. In 55 of these patients, postoperative bleeding was also measured. The average intraoperative blood loss with neurolept anesthesia was 8.2 +/- 5 ml/min, with halothane anesthesia 6.6 +/- 6.3 ml/min and with epidural anesthesia 3.8 +/- 2.3 ml/min. The difference of blood loss in the epidural group and in the groups receiving general anesthesia is highly significant. Average systolic and diastolic blood pressures were lower during operation in the epidural group than in the other two groups. Statistical analyses failed, however, to show a significant correlation between blood pressures and blood loss in the individual patient. Thus, the ultimate explanation for the diminished bleeding associated with epidural anesthesia is not definitely ascertained. The average postoperative bleeding was not significantly different among the three anesthetic groups.

Adult↗
PubMedDate not supplied

Risk factors and raised atherosclerotic lesions in coronary and cerebral arteries. Statistical analysis from the Oslo study.

In 1972-1973, about 16,200 men living in Oslo, aged 40 to 49 years, were examined for cardiovascular disease, and had a number of coronary risk factors measured. This report gives the results of 129 autopsied cases with regard to the association between raised atherosclerotic lesions in coronary and cerebral arteries and various coronary risk factors. For coronary raised lesions, the high density lipoprotein (HDL) cholesterol ratio was the most significant risk factor. Systolic blood pressure and total serum cholesterol were also significantly associated. Physical activity at work and at leisure, nonfasting triglycerides, and cigarette smoking did not show a significant association with coronary artery raised lesions. The association between total serum cholesterol and systolic blood indicates that total serum cholesterol may be more important than systolic pressure in the synergism affecting the development of coronary atherosclerosis. For cerebral artery raised lesions, blood pressure was the most important risk factor, even though serum cholesterol was highly associated with the lesions. The interaction analysis also suggested that blood pressure was more important than serum cholesterol in the synergism.

Adult↗
PubMedDate not supplied

Effect of alteration in triglyceride levels on factor VII-phospholipid complexes in plasma.

Clotting Factor VII activity emerges as a highly significant predictive factor for development of cardiovascular disease (CVD) in prospective trials. We have previously shown that in hypertriglyceridemic individuals a fraction of their clotting Factor VII molecules is present in an activated state in phospholipase C-sensitive complexes in plasma. These complexes may explain the increased Factor VII activity observed to be a predictive factor for CVD. We demonstrate here that the level of such complexes is amenable to dietary intervention and that the alteration in Factor VII complex levels correlates closely with the corresponding alteration in triglycerides.

Cardiovascular Diseases↗
PubMedDate not supplied

Quantitation of atherosclerosis in femoral arteriography with ECG gated exposures.

Using a densitometric method introduced in 1977 by Crawford et coll. the volumes of segments of the femoral artery were calculated from two angiographic series in each of 13 patients. ECG gated exposures were used to minimise the error of the method. The reproducibility of the method was found to be better than in a previous study in which ECG gating was not used. The method may therefore be of use in long term angiographic follow-up studies of atherosclerotic lesions, although the impact of different investigation parameters on methodologic precision is still not fully known.

Arteriosclerosis↗