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Biomedical subjects

I G Jones

Publications and source records attributed to I G Jones.

At least 55 records · Page 3Linked to original sources
PubMed1986

Measles, mumps, and rubella: the need for a change in immunisation policy.

There is growing evidence that the present policy of childhood immunisation in the United Kingdom is inadequate. It is unlikely ever to achieve complete eradication of the congenital rubella syndrome and measles, and the problem of mumps has not even begun to be addressed. After a coordinated campaign to increase uptake of immunisation in Fife the uptake of rubella immunisation in teenage girls increased from 75% in 1981 to 94% in 1985 and the uptake of measles vaccination in preschool children from 55% in 1981 to 81% in 1985. There are a few girls each year who do not accept rubella immunisation, whose immune state is unknown, and who are consequently at risk of rubella during future pregnancies. Despite the increased uptake of measles vaccine over the past four years there is currently an epidemic of measles in Fife, with 544 notified cases in the first quarter of 1986. In 1984, 19 Fife residents were admitted to hospital because of complications of mumps. The time is ripe for a complete reassessment of the national immunisation policy.

Adolescent↗
PubMed1985

Measles immunisation: results of a local programme to increase vaccine uptake.

Investigations showed that the measles immunisation programme in our health board was a failure. Surveys of health care staff and parents to determine the cause of the problem identified several aspects of concern: the immunisation of children was often left to parental initiative, with only 29% of general practitioners playing an active part in recalling children by the 15th month of age; general practitioners, clinical medical officers, paediatricians, and health visitors all required education on several aspects of measles immunisation; parents also required more information about the importance of preventing this disease. A coordinated effort to remedy these problems was introduced which achieved an increase of 13% in vaccine uptake during 1984. These findings may have implications beyond our own area.

Attitude to Health↗
PubMed1983

Cardiomegaly in Northern Zambia: clinico-pathological observations.

Massive cardiomegaly (heart weight above 400 g in females and 450 g in males) was studied in 26 Zambians examined post mortem. The aetiologies found were: hypertensive heart disease alone in six cases; hypertensive and alcoholic heart disease in two cases; alcoholic heart disease alone in five; alcoholic and pulmonary heart disease in one; alcohol with possible hypertensive heart disease in one. Eleven cases were classified as being idiopathic mainly due to lack of data and in five of these hypertension was suspected as being the cause. The series qualitatively represented the spectrum of non-rheumatic heart disease seen in patients admitted to the Central Hospital, Ndola, Zambia. Hypertension had a central role in the causation of massive cardiomegaly. Follow-up of several patients enabled observations on the cardiac effects of hypertension and alcoholism operating simultaneously and on the relationship between hypertension and congestive cardiomyopathy.

Adult↗
PubMed1983

John Snow, the broad street pump and modern epidemiology.

John Snow was a genius in epidemiology. His achievement was to evolve an elegant, internally and externally consistent theory which concerned the mechanisms and processes involved in every aspect of the subject he had chosen to study. In order to do this he did not restrict himself to any method. He used all skills available to himself and his colleagues. He published his theory, and practical suggestions for the prevention of cholera arising out it, both internally in medical meetings and to the medical press, and to the public in the form of pamphlets and in reports addressed to the appropriate authority. This surely should be the objective of all epidemiological work.

Cholera↗
PubMed1980

Massive splenomegaly in Northern Zambia. I. Analysis of 344 cases.

Massive splenomegaly is common in Northern Zambia. Nearly 40% of 344 patients were diagnosed as Tropical Splenomegaly Syndrome of malarial origin. Portal hypertension, lymphoreticular and haemopoietic malignancies, and schistosomiasis accounted for another 46%. The common causes of splenomegaly show differences of frequency within Zambia and also between Zambia and other African countries.

Adolescent↗
PubMed1980

Massive splenomegaly in Northern Zambia. II. Schistosomal splenomegaly and elevated IgG.

Twenty-three patients from Northern Zambia with massive splenomegaly due to chronic schistosomiasis were studied. The mean serum IgG levels were found to be extremely high compared with local blood donors and local patients with Tropical Splenomegaly Syndrome (TSS). Mean serum IgG levels also appear to be higher in Zambians with schistosomal splenomegaly than in those reported in patients from most other areas. Mean IgM levels of patients with schistosomal splenomegaly were higher than those of local blood donors, but not as high as in the TSS. IgG and IgM estimations are sometimes of value in the differential diagnosis of splenomegaly in the tropics.

Adolescent↗
PubMed1978

Localization of the ribonucleotide sites in rat liver mitochondrial deoxyribonucleic acid.

Supercoiled rat liver mitochondrial DNA is relaxed by treatment with ribonucleases A, T1 or H. All the supercoiled mitochondrial DNA is sensitive to ribonuclease H and ribonuclease A, but only 35% of the supercoiled population is sensitive to ribonuclease T1. Removal of the ribonucleotides with calf thymus ribonuclease H, followed by denaturation of the mitochondrial DNA and analysis of the single-strand fragment lengths in the electron microscope, showed that the ribonucleotides were randomly located on both strands of the DNA. Endonuclease-S1 digestion of mitochondrial DNA after removal of the ribonucleotides reveals that no unique fragments are produced and ribonucleotides are randomly distributed with respect to one another. The average number of ribonucleotide sites per molecule was estimated to be between 8 and 13. Two possible mechanisms for the origin of ribonucleotide sites are discussed.

Animals↗
PubMed1977

Misuse of statistical methods: critical assessment of articles in BMJ from January to March 1976.

Sixty-two reports that appeared as Papers and Originals (excluding short reports) in 13 consecutive issues of the British Medical journal included statistical analysis. Thirty-two had statistical errors of one kind or another; in 18 fairly serious faults were discovered. The summaries of five reports made some claim that was unsupportable on re-examination of the data. Medical investigators should consult with people who have a real understanding of statistical methods throughout their projects.

Periodicals as Topic↗