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Biomedical subjects

I Ferrer

Publications and source records attributed to I Ferrer.

At least 361 records · Page 20Linked to original sources
PubMed1985

Study of a photo-induced lysozyme-riboflavin bond.

Irradiation of lysozyme in the presence of riboflavin results in the formation of a lysozyme-riboflavin adduct. Reduction and carboxymethylation of the four disulfide bonds as well as the chemical modification of the Tyr residues and the photochemical alteration of the His residue in lysozyme, do not affect the formation of the photo-induced lysozyme-riboflavin bond. When the lysozyme-riboflavin adduct was subjected to mild acid hydrolysis and ion exchange chromatography, the retention of a compound containing 14C-riboflavin was observed. Free 14C-riboflavin, on the contrary is not retained by the column. The photo-oxidation of free Trp in the presence of 14C-riboflavin, gave a compound which bound to the ion exchange resin like the above-mentioned derivative. The photo-oxidation of the Trp residues in lysozyme and in peptides obtained from lysozyme showed very high quantum yields, and these values were directly related to the incorporation of 14C-riboflavin in these samples.

Light↗
PubMed1984

Leigh's syndrome in an adult.

A 55-year-old man with a subacute onset of slurred speech, ataxia, nystagmus, extrapyramidal rigidity, decreased tendon reflexes, vomiting, bilateral optic atrophy, and clonic jerks died of bronchopneumonia and respiratory failure. Neuropathological examination showed lesions characteristic of subacute necrotizing encephalopathy. Clinicopathological observations of reported cases of Leigh's syndrome in the adult are reviewed.

Brain↗
PubMed1984

A Golgi analysis of unlayered polymicrogyria.

The cytoarchitectonics of the cerebral unlayered polymicrogyria located at the borders of a bilateral porencephalic defect is characterized by minute convolutions not exteriorized by sulci, in which blood vessels and increased numbers of fibrillary astrocytes are present in the fused molecular layers. The cellular organization, based on the analysis of Golgi sections, differs among gyral, intermediate, and sulcal regions and represents variable degree of cellular damage and structural organization of the cerebral mantle injured approximately in gestational month 5. Polymicrogyria may be produced by incomplete ischemia of radial territories vascularized by cortical blood vessels penetrating at right angles from the surface which is the result of the imbalance between the impaired cerebral blood flow of occluded large prerolandic arteries, responsible for the porencephalic defect, and the arterial meningeal anastomoses. Abnormal folding in polymicrogyria may be generated by lateral differences in the cortical thickness of adjoining areas, and by the imbalance in growth rates of laterally contiguous cortical regions.

Cerebral Cortex↗
PubMed1984

Fine structure based on the Golgi method of the abnormal cortex and heterotopic nodules in pachygyria.

The structure of the four-layer abnormal cerebral cortex and of the heterotopic cerebral nodules in pachygyria has been studied by means of the Golgi method. The external cellular layer is formed by neurons closely mimicking, in morphology and distribution, those observed in layers V-VI of the normal cortex, although major abnormalities in orientation of pyramidal cells are a prominent abnormal feature. The internal cortical cellular layer is composed of several neuron types in which no distinctive layered organization can be detected. Heterotopic cerebral nodules are formed by neurons of the cortical types with random orientation of their cellular processes. Some extrinsic axons have been demonstrated, thus suggesting lack of isolation of heterotopic nodules.

Cerebral Cortex↗
PubMed1984

Familial agenesis of the corpus callosum with hypothermia and apneic spells.

Two siblings, a boy and a girl, with agenesis of the corpus callosum, apneic spells, attacks of apnea, cyanosis and spontaneous hypothermia, are reported about. Both children died after a few months of life. Postmortem examination revealed a severe spongiosis of the white matter in addition to the agenesis of the corpus callosum and septum pellucidum, in both cases.

Agenesis of Corpus Callosum↗
PubMed1984

The cerebral cortex of the new-born guinea pig. A quantitative Golgi study of the layer V pyramidal cell.

Quantitative studies have been performed in pyramidal cells (layer V) of the guinea pig's cerebral cortex when the animal were still-born and then not influenced by external sensorial stimuli nor by environment experience. Results related to basal ramifications of the pyramidal cells are similar to those reported in other species. Dendritic spines showed an increased in density along the length of the apical dendrites in a logarithmic regression. A similar pattern of distribution of dendritic spines along the apical dendrite was observed in a given animal, but interindividual variability was demonstrated.

Animals↗
PubMed1984

[Adenohypophysis secretion in children: comparison between a combined test and isolated stimulation tests].

Pituitary function is assessed by a combined test (insulin, TRH, LH-RH) in twenty prepubertal children with constitutional delay of growth and/or retarded bone maturation, and is compared with another group of 31 children with the same diagnostic assessed by an isolated test. Plasma GH, TSH, PRL and cortisol levels had not interferences when the provocation stimuli were administrated in combined form or isolated one. When basal cortisol levels were near 25 mcg/100 ml, the insulin induced hypoglycemia did not lead higher values. Simultaneous evaluation of pituitary function can assessed in a short period of time (two hours) with minimum disturbs in children and exhibits a good information of the hypothalamo-pituitary axis.

Blood Glucose↗
PubMed1984

Cerebral malformation induced by prenatal X-irradiation: an autoradiographic and Golgi study.

Brain malformations are produced after X-irradiation at different post-conceptional ages in the rat. Malformed cortical patterns result from abnormal organisation and capricious orientation of the neurons, while a radical migratory pattern of neuroblasts outwards to the cerebral cortex is preserved in animals irradiated on the fourteenth, sixteenth or eighteenth days of gestation. Migratory disturbances are restricted to the large subcortical ectopic masses found in rats irradiated on the fourteenth gestational day and to pyramidal ectopic nodules in the hippocampus in rats irradiated on the sixteenth gestational day. Subcortical ectopic masses develop from ectopic germinal rosettes and are formed by several types of cortical neuron distributed in a stereotyped pattern. The presence of large numbers of intrinsic, afferent and efferent connections are indicative of integrative functions of the subcortical masses.

Abnormalities, Radiation-Induced↗
PubMed1983

Angiogenic activity in fluid samples from tumoral patients.

Tests were performed to study the angiogenic activity in samples of pleural fluid, ascites and cerebrospinal fluid, in patients with solid tumors and non-neoplastic diseases such as cerebrovascular accidents, cirrhosis, and congestive heart failure. The measurement of the angiogenic activity was carried out on chorioallantoid chick embryo membrane. The cerebrospinal fluid showed angiogenic activity in patients with primitive tumors of the central nervous system and also in cases where the tumor had extended into other organs. The cerebrospinal fluid of controls without tumor revealed angiogenic activity in 28% of the cases. There was a direct correlation between positive assays and age. Sixty-two percent of the samples of ascites from cancer patients were positive. Only 25% of the controls were positive. Only 10% of the pleural fluid from cancer patients was negative, and 75% of the control samples were negative.

Adult↗
PubMed1983

Cerebral ganglioglioma. A Golgi study.

The morphological characteristics of neurons revealed by Golgi's method are reported in a case of cerebral ganglioglioma. Spindle-shaped (leptodendritic) neurons and radiated type I neurons form the bulk of this tumour. According to Ramon-Moliner (1968) isodendritic neurons (both leptodendritic and radiate type I) are philogenetically primitive cells and differ greatly from those observed in most of the deep cerebral nuclei of the mammalian's brain.

Adolescent↗
PubMed1983

Growth of abnormal neurites in atypical Alzheimer's disease. A study with the Golgi method.

A cerebral biopsy was performed in a 39-year-old male patient with subacute paraparesis who later developed severe dementia and moderate cerebellar involvement. The histological examination showed a marked neuronal loss, severe neurofibrillary degeneration, and a great number of senile plaques. No PAS-positive plaques or amyloid angiopathy could be demonstrated. Golgi's sections showed (a) meshwork of fine dendrites located distally to the soma, (b) thick, coarse dendrites full of synaptic spines in neurons otherwise lacking these structures, and (c) thick dendrites with distal varicosities and filopodium-like processes resembling growth cones. These changes have been interpreted as acquired abnormal receptor sites and represent unique facts of a group of diseases not clearly defined, including atypical Alzheimer's disease and some cases of familiar Alzheimer's disease.

Adult↗
PubMed1983

Mixed carcinomatous neuropathy in patients with lung cancer and lymphoma.

A clinical, electrophysiological and histological study of the peripheral nerve was performed on 62 patients with lung cancer and 30 patients with lymphoma. There was a mild peripheral neuropathy (MPN) in 17.7% of patients with lung cancer and in 10% of those with lymphoma. MPN was related to the degree of weight loss. Histological studies of 5 patients with MPN demonstrated a loss of large myelinated fibers in all patients, axonal degeneration in 2 and remyelination in 3 patients. Electromyographic and histological findings indicate a primary axonal neuropathy with remyelination, probably secondary to axonal damage. 2 patients with lymphoma developed a severe neuropathy that remitted in 1 patient. The main pathological abnormality was segmental demyelination in both cases. Immunofluorescence studies were negative in all cases with mild or severe neuropathy.

Adolescent↗