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Biomedical subjects

I Farine

Publications and source records attributed to I Farine.

At least 37 records · Page 2Linked to original sources

The clinical importance of factor XI deficiency in an Ashkenazi Jewish patient.

Factor XI (PTA) deficiency, a coagulopathy, has been found to be relatively common in Ashkenazi Jews. Clinically it may manifest itself by varying forms of hemorrhage including postoperative bleeding. It is recommended that all Ashkenazi Jews have a partial thromboplastin time (PTT) coagulation test before surgery in order to rule out this coagulopathy, and if the PTT is abnormal a Factor XI assay should be done to confirm the diagnosis and ensure that proper therapy can be provided. A surgical case is presented with its ensuing complications resulting form lack of such information.

Adult↗

Osteochondral graft in the treatment of osteonecrosis of the femoral condyle.

A 65-year-old woman with spontaneous osteonecrosis of the medial femoral condyle of the left knee was treated by a fresh cadaveric osteochondral bone graft. The latest follow-up examination at 2.5 years demonstrated good functional results, as well as radiographic evidence of satisfactory consolidation with no aseptic necrosis or osteoarthritis.

Aged↗

[Experimental traumatic epiphysiolysis (author's transl)].

Two experimental series of epiphysiolysis, with and without displacement, were performed on 100 young rabbits in each group. The histological site of the epiphysiolysis was demonstrated, and the healing process studied. The basic healing process is induced by the vascular metaphyseal penetration of the separation line, as shown in the epiphysiolysis without displacement. A compensative mechanism appears in the series of epiphysiolysis with displacement, consisting of an epiphyseal vascular penetration of the epiphyseal plate, performing then the embryonal anatomical pattern. The vascular epiphyseal channels close progressively after they reach the metaphyseal vessel. If they do not join the metaphyseal vessels quickly enough, or in sufficient number, they are invaded by osteoblastic cells and fibrous or bony bridges will be created through the epiphyseal plate. These bridges are responsible for growth retardation, axial deviation and even early closure of the epiphyseal plate.

Animals↗

Choline acetyltransferase for differentiation between human motor and sensory nerve fibers.

A rapid and precise nerve fascicle identification method based on the enzymatic activity of choline acetyltransferase (choline acetylase, or ChAC) is described. Motor nerve facicles demonstrated significantly higher ChAC activity in comparison to sensory nerve facicles. Based on this difference in activity, matching of nerve fascicle cut ends is possible in cases of recent trauma.

Afferent Pathways↗

Persistent dislocation of the shoulder in elderly patients.

Four elderly patients with longstanding unrecognized dislocation of the shoulder were treated by physiotherapy only. Good functional results, associated with a greatly increased range of pain-free motion, demonstrate the usefulness of conservative treatment in cases of persistent dislocation of the shoulder in the elderly.

Aged↗

Sequential use of technetium 99m MDP and gallium 67 citrate imaging in the evaluation of painful total hip replacement.

Fourteen patients with 20 total hip joint replacements were studied for 14 painful prosthetic hips. Clinical examination, plain film radiographs and 99Tcm-MDP bone scans failed to differentiate between infection and mechanical loosening of a prosthesis. Sequential use of 99Tcm-MDP and 67Ga-citrate bone scans were performed in an attempt to discover underlying infectious process. Increased focal uptake of both radiopharmaceuticals over the same hip indicated an infectious process responsible for prosthetic loosening. There were no false positive gallium examinations. Sequential use of 99Tcm-phosphate compounds and 67Ga-citrate is recommended for differentiation between mechanical loosening of a prosthesis and loosening of a prosthesis secondary to an infectious process.

Adult↗

Distal transfer of the greater trochanter in cox vara.

Seven patients (nine hips) who suffered from coxa vara were treated by distal transfer of the greater trochanter. The operation eliminated or markedly diminished the preoperative Trendelenburg sign, thus improving gait. In three patients (four hips) operated upon at the aged of 9 and 12 years, the initial coxa vara was converted into an almost normal valgus kemoral neck. There was one poor result due to technical failure.

Adolescent↗

Fracture healing in rabbits after osteotomy using the CO2 laser.

Fracture healing was studied in 28 rabbits after their femurs had been osteomized using the carbon dioxide laser. Twenty rabbits whose femurs were osteotomized by means of a Gigli saw served as the control group. Fracture healing was initially delayed in the laser cut femurs, yet after 60 days no significant difference between the groups could be detected. The initial delay was caused by thermal damage to the laser cut bone edges. Further fragmentation of the damaged bone occurred during the immediate postoperative period.

Animals↗