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Biomedical subjects

I Eriksson

Publications and source records attributed to I Eriksson.

At least 127 records · Page 7Linked to original sources
PubMed1979

Arterial lesions of the radial artery in uraemic patients.

Arterial specimens from the radial artery were removed in connection with Brescia fistula operations on 15 uraemic patients and were studied by light and electron microscopy. The patients lacked clinical signs of arterial insufficiency. Radial artery specimens from 15 humans that underwent forensic post-mortem examination served as controls. The intima of the uraemic patients was significantly thicker than that of the controls. In 8 of the uraemic arteries light microscopy disclosed necrotic areas in the media and in 2 cases such areas in the intima, compared to only one case with patchy medial necrosis in the controls. Calcification was histochemically demonstrated in 6 of the uraemic arteries while none of the controls showed this change. The presence of degenerated and necrotic smooth-muscle cells was verified at the ultrastructural level. Furthermore, modified smooth-muscle cells appeared in the intima and the media and were probably of significance for the synthesis of the increased amounts of collagen and mucopolysaccharides that could be demonstrated. Ultrastructurally evidence of calcification could be demonstrated in the internal elastic membrane and in necrotic areas in the intima and the media. In the latter localization the calcification process seemed to start in relation to extracellular vesicular structures, probably representing cell debris. The possible significance of the observed changes for the development of symptom-giving arterial disease is discussed.

Adult↗
PubMed1979

Surgical classification of abdominal aortic aneurysms.

A new surgical classification of abdominal aortic aneurysms is proposed. The classification is based upon the clinical features immediately prior to surgery and the findings during operation. Group I consists of elective cases without symptoms, group II elective cases with symptoms, group III suspected rupture, group IV rupture without clinical shock and group V rupture with clinical shock. The mortality in a material of 129 cases was 0 in group I and progressed to 74% in group V. The mortality distribution was confirmed by a collective review of the literature. The proposed classification sheds light upon the natural history of the disease, prognosis and indication for operation.

Aged↗
PubMed1978

Somatic cell hybrids between human lymphoma cell lines. V. IdUrd inducibility and P3HR-1 superinfectability of Daudi/HeLa (DAD) and Daudi/P3HR-1 (DIP-1) cell lines.

We have studied two types of somatic cell hybrid with regard to expression of the Epstein-Barr virus (EBV) cycle and its regulation. The first, DIP-1, a hybrid formed between two human lymphoma EBV producers (Daudi and P3HR-1), contained EBV DNA, expressed the virus-determined nuclear antigen (EBNA), andwas a producer of the EBV-associated antigens EA (early antigen) and VCA (viral capsid antigen). The second, DAD, a hybrid series of clones formed between Daudi and a HeLa cell derivative (D98), differed with regard to the expression of EBNA, EA, VCA and the content of EBV DNA. EA was regularly induced in the EBV DNA-containing hybrids following treatment with iododeoxyuridine (IdUrd). This induction was greater in lines spontaneously expressing EA. In two hybrids, DIP-1 and DAD10, VCA and virus DNA synthesis were also induced in the presence of IdUrd, the latter being detected by in situ hybridization with P3HR-1 EBV complementary RNA. Finally, while DIP-1 was superinfectable by the P3HR-1 EBV strain, the DAD series of hybrids were refractory to P3HR-1 superinfection and lacked EBV receptors.

Antigens, Viral↗
PubMed1978

Intraoperative angiography in arterial surgery.

Intraoperative angiography was performed in 136 cases of surgical reconstruction of the aorta, iliac, femoral and carotid arteries. In 39 cases pathological angiograms were found at operation, some of them quite unsupected. The most common pathological finding was non-occluding thrombosis, but intimal lesions caused by vessel clamps and incomplete endarterectomies were not uncommon. Immediate surgical reexploration and revision resulted in a high frequency of open reconstructions at follow-up, which was performed 1--24 months postoperatively. On the other hand, nonrevised reconstructions with pathological angiograms usually failed in the early postoperative period. In cases with normal intraoperative angiograms the result at follow-up was excellent. In addition to electromagnetic flow determination, intraoperative angiography is a most valuable adjunct in the assessment of vascular surgery during operation and should be used more frequently. All pathological findings in the angiograms must be seriously considered and lead to reexploration and revision.

Angiography↗
PubMed1978

Abdominal aortic aneurysm in homocystinuria.

The first reported case of abdominal aortic aneurysm complicating homocystinuria is presented. The clinical features and microscopic findings were identical to those of an atherosclerotic aneurysm. Homocystinuria may stimulate Marfan's syndrome but can be differentiated by the cyanide-nitroprusside screening test for homocystine in urine. Although homocystinuria is accompanied by an increased risk of thrombosis, surgical treatment of complicating diseases should not be avoided. Pyridoxine treatment is recommended.

Adult↗
PubMed1977

Clinical evaluation of high-frequency positive-pressure ventilation (HFPPV) in laryngoscoy under general anaesthesia.

A technique for automatic ventilation during laryngoscopy under general anaesthesia was evaluated in a lung model and in 5 patients (3--57 y) submitted for routine laryngoscopy. this technique has been given the name laryngoscopic HFPPV and utilizes an insufflation frequency (f) of 60 per min and a relative insufflation time (t%) of 22%. Ventilation is given via a nasotracheal insufflation catheter. Laryngoscopic HFPPV permits laryngeal surgery with a virtually unobstructed surgical field under complete muscular relaxation. The alveolar ventilation of the patient may be controlled by adjustment of the pressure of the anaesthetic gas mixture and there is no air entrainment through the larynx during insufflation. This makes possible use of O2/N2O mixtures and the oxygenation of the patient may be controlled by adjustment of the oxygen concentration of the anaesthetic gas mixture. As there is a continuous upward has flow through the larynx, blood or pieces of loose tissue are not sucked down into the trachea. A simple ventilation nomogram for clinical use is proposed. Adequately used, this nomogram guarantees safe ventilation during laryngoscopic HFPPV. An Fio2 of 0.3--0.4 gives adequate arterial oxygenation.

Anesthesia, General↗
PubMed1977

Arterial disease with ischemic ulcerations in renal transplanted recipients.

Four cases of wide-spread arterial calcifications and peripheral necroses developing after successful renal transplantation are presented. In two cases parathyroidectomy was performed to prevent progress of the peripheral ischemic ulcers. In one of these cases, this was followed by healing of the necroses. In the two other cases parathyroidectomy had been performed because of hypercalcemia in the post-transplantation period. Ischemic ulcers appeared in these patients during treatment with vitamin D and healed after withdrawal of this therapy. Prevention of uremic arterial disease might be obtained by early control of serum phosphate levels and by renal transplantation at an early stage of renal disease. Parathyroidectomy should be considered in the treatment of developing peripheral gangrene in uremic patients and renal transplant recipients. Also, there are obvious hazards connected with vitamin D therapy in these patients.

Adult↗
PubMed1977

Analysis of factors affecting limb salvage and mortality after embolectomy.

A series of 108 arterial embolectomies in 91 patients performed during 1960-64 and 1970-74 is presented. The Fogarty catheter was introduced in our clinic between these periods. Early mortality was 56 and 29%, respectively. Limb salvage rate according to our definition was 38 and 53%, respectively. We found a significantly higher mortality when embolies were located proximal to the profunda femoral artery compared to more distally located embolies. Amputation frequency was 4% after embolectomies performed within 12 hours, but 27% with longer duration of symptoms. Limb salvage rate was significantly higher in patients treated with anticoagulation. In conclusion it is stressed that local surgical therapy should be combined with adequate measures against cardiac failure and other systemic complications. This therapeutic principle is particularly important in cases with proximal embolies.

Aged↗
PubMed1975

Arterial calcification and progressive peripheral gangrene after renal transplantation. Report of two cases treated with parathyroidectomy.

Two cases of progressive arterial calcification and peripheral gangrene after successful renal transplantation are presented. Parathyroidectomy was performed and was followed in one case by healing of the peripheral necroses. It is suggested that parathyroidectomy should be considered in similar cases even in the absence of hypercalcemia.

Arteriosclerosis↗
PubMed1975

High-frequency positive-pressure ventilation (hfppv) during transthoracic resection of tracheal stenosis and during peroperative bronchoscopic examination.

Operation of a patient with intrathoracic tracheal stenosis using a new ventilation technique (HFPPV) is described. The technique permits tracheoscopy during ventilation and operation, thus enabling exact location of the stenosis to be obtained. Further, peroperative tracheoscopic checking of the anastomosis can be carried out. Resection and anastomosis can be performed without interference of a bulky endotracheal tube.

Adult↗