Biomedical subjects

I Enge

Publications and source records attributed to I Enge.

At least 55 records · Page 3Linked to original sources

PubMed1976

Complication rates of selective percutaneous transfemoral coronary arteriography. A review of 1094 consecutive examinations.

A review is presented of 1094 selective coronary artery studies during a 3-year period in which 7001 coronary artery injections were performed using the percutaneous transfemoral artery approach as described by Judkins. A total of 24 serious complications occurred, including 11 ventricular fibrillations, 5 asystoles or severe bradycardias, 3 acute myocardial infarctions and 5 cerebral vascular accidents. There were 5 deaths, giving an overall mortality rate of 0.46%. Causes of individual complications are analyzed. The incidence of serious cardiac complications did not differ significantly from that reported in the literature with the Sones technique. The Judkins technique is a simple and reliable method for selective coronary arteriography. In our opinion, the incidence of complications can be kept at an acceptably low level by meticulous examination techniques.

Acute Disease↗

PubMed1976

Myocardial blood flow in the diving seal.

Grey seals exhibit a marked drop in heart rate, a slight decrease in ventricular contractility, and an essentially unchanged stroke volume upon diving. In the present study, we have demonstrated that the resulting drop in cardiac output is associated with a 90% reduction of coronary blood flow. Such reduction of myocardial blood flow takes place despite a significant increase in effective coronary driving pressure, and is indicative of a 800% increase in coronary vascular resistance. This means that the circulatory adjustments displayed by the diving seal (i.e. a reduction of the workload on the heart) are so effective that myocardial blood flow can be reduced to 10% of the pre-dive value without loss of cardiac function and blood pressure. It is suggested that even partial simulation of such a circulatory state might be a successful approach in the treatment of ischemic injuries in the heart of man.

Animals↗

PubMed1976

Metrizoic acid (Isopaque coronar) used in man for cardiac angiography.

Isopaque Coronar, a radiopaque agent, was given (10,000 injections) to 2,028 patients during angiocardiographic studies done over a three-year period. With two exceptions, all complications occurred during right coronary artery injection. Seven cases of ventricular fibrilation, and 5 of marked bradycardia/asystole, were associated with injection of the medium. Isopaque Coronar is well tolerated by patients during cardiac examinations. Factors which may help to explain the low complication rate are discussed.

Angiocardiography↗

PubMed1976

False positive diagnostic tests and coronary angiographic findings in 105 presumably healthy males.

Among 2014 presumably healthy males aged 40-59 years coronary heart disease (CHD) was suggested in 115 in the presence of one or more of the following criteria: 1) a WHO-questionnaire on angina pectoris positive on interview, 2) typical angina during a near maximal bicycle exercise test, 3) a positive exercise ECG during and/or post exercise, 4) a Minnesota Code 1.1 on a resting ECG. Diagnostic coronary angiography was offered to all 115 CHD-suspect cases. Six refused angiography and four others were excluded. Of the remaining 105, thirty-six had less than 50% obstruction of any major coronary artery (34.3%). Eighteen (17.1%) had single, 25 (23.8%) had double and 26 (24.8%) had triple vessel disease. In 62 of the 69 with pathologic angiograms at least one obstruction greater than or equal to 75% was found. Eighty percent of the cases with proven CHD were greater than or equal to 50 years. All CHD-suggestive criteria had approximately the same diagnostic performance regardless of age, i.e., approximately one false positive/two true positives. Except for one retroperitoneal hematoma no complications to angiography occurred.

Adult↗

PubMed1975

Angiography in vascular injuries of the extremities.

Angiographic findings in 31 cases of vascular injuries of the extremities sustained to a variety of traumas are reported. Angiography will usually demonstrate the type and site of the lesion as well as the presence and extent of collaterals. Its value in cases with obscure clinical findings as well as its importance for the therapeutic approach is stressed.

Adolescent↗

PubMed1975

Left coronary artery contrast transit time.

With our method for selective left coronary arteriography it is possible to determine the time interval between the start of the contrast injection into the artery and the appearance of the contrast in the coronary sinus. This time-interval, coronary contrast transit time (CCTT), has been determined in patients with or without obstructing coronary artery disease. The average CCTT was about four seconds with some individual variations. The CCTT tended to decrease with advancing age. There was no significant difference between the CCTT in patients with normal angiograms compared to the CCTT in patients with coronary stenoses or occlusions. In the latter patients, there was no correlation between the degree of narrowing on the angiograms and the time-measurements. Alternative explanations for these findings are discussed.

Adult↗

PubMed1975

The role of the liver lymphatics in the transport of non-erythroid bilirubin during different stages of experimental cholestasis.

The role of the liver lymphatics in the regurgitation of bilirubin during the different stages of cholestasis has been a matter of debate. Earlier studies have shown that 14C-bilirubin injected intravenously one hour after induction of cholestasis was rapidly and completely cleared from the blood and appeared in the thoracic duct lymph in high concentration. During chronic cholestasis the injected 14C-bilirubin was delivered directly back to the blood after conjugation in the liver. The aim of the present study was to investigate the role of the lymphatics in the transport of non-erythroid bilirubin (NEB), a metabolic product of certain tissue haemes, produced mainly in the liver. The study was carried out in dogs. Five dogs were studied in the first hours following bile duct obstruction, and five others after at least one week of cholestasis. 14C-delta-aminolevulinic acid was given as a NEB precursor. In contrast to the results obtained with 14C-bilirubin injection, evidence for a delivery of conjugated labelled NEB directly to the blood during acute cholestasis was found. The concentration curves for NEB and non-NEB radioactivity in the thoracic duct lymph indicated the presence of a secondary biliolymphatic regurgitation. In chronic cholestasis no evidence for such a biliolymphatic regurgitation of NEB was found.

Acute Disease↗

PubMed1974