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Biomedical subjects

I B Ushakov

Publications and source records attributed to I B Ushakov.

At least 19 recordsLinked to original sources
PubMed2006

Effect of radioprotector indralin on carboplatinum hemotoxicity.

A decrease in carboplatinum hemotoxicity was detected in experiments on C57B1 mice treated with the drug in combination with indralin (urgent radioprotector). Carboplatinum in a dose of 125 mg/kg, injected intraperitoneally, caused 80-100% death; the median term of death was 6 days (3-17). Single oral dose of indralin (100 mg/kg) during the 1st min or 15 min after carboplatinum injection (125 mg/kg) increased animal survival by 40.0-46.7% by day 20 of the experiment primarily during the period of manifest hemotoxicity (days 7-17), indralin injected 1, 2, or 4 h after carboplatinum exhibited no chemoprotective effect.

Animals↗
PubMed2006

[Systemic hemodynamic reactions in passive orthostatic test].

The authors suggested a method to evaluate orthostatic stability in passive orthostatic test. Cardiovascular reaction to venous deposition caused by posture change is measured with computer complex "Biankor" monitoring left ventricle parameters. The article covers analysis of systemic hemodynamic reactions to orthostatic test with consideration of hemodynamic type, diagnostic criteria to evaluate individual cardiovascular reaction to orthostatic test.

Adult↗
PubMed2005

[Magnetocardiography as a new diagnostic method for cardiologic diseases in occupational medicine].

Magnetocardiography as a new diagnostic method for cardiologic diseases in occupational medicine. The article covers possibilities of magnetocardiography as a promising diagnostic method for cardiologic diseases in occupational medicine. The studies used 7-channels magnetocardiographic complex MKG-6073-M. The authors applied standard exercise tests in 6 apparently healthy examinees.

Equipment Design↗
PubMed2004

Effect of melatonin, ascorbic acid, and succinic acid on the cumulative toxic effect of repeated treatment with gammafos (amifostine).

Daily treatment of outbred albino mice with gammafos in radioprotective doses of 300 and 500 mg/kg for 4 days produced a cumulative toxic effect. This effect was not observed after decreasing the dose of gammafos to 100 mg/kg. Repeated peroral administration of melatonin and ascorbic acid in a dose of 200 mg/kg 30 min before treatment with gammafos reduced its cumulative toxic effect. Succinic acid in a dose of 100 mg/kg was ineffective under these conditions. The cumulative death time for 50% animals receiving gammafos alone or in combination with melatonin, ascorbic acid, and succinic acid was 3.08, 4.29, 4.06, and 2.97 days, respectively.

Amifostine↗
PubMed2004

[Adaptation potential of man].

Discussed in the paper are the scientific-and-practical fundamentals, examples and outlooks for using, in human ecology, the adaptation potential, i.e. a quantitative expression of a degree of the function state of the body and of its systems characterizing the body's ability to an adequate and reliable respond to a variety of unfavorable factors as well as the dynamics of their parameters by sparingly using the functional reserves and by avoiding the premorbid condition.

Adaptation, Physiological↗
PubMed2004

[Ergonomic bases of improving the quality of military medical equipment].

The definitions for the concepts of quality of military medical equipment (MME) sample and quality indices are given. The general ergonomic indices of the sample quality are presented. The heterogeneity of elements of "medical specialist--military medical equipment--the wounded--environment" system is shown the successful synthesis of which requires the co-ordination of technical, constructive factors, characteristics of the sample and human (personal) factors of medical specialist. The ergonomic defects typical of MME samples are revealed and the ways to improve the ergonomic characteristics of MME samples are charted. Some ergonomic aspects to improve the MME sample quality are described.

Equipment Design↗
PubMed2003

[Depleted uranium: radiation and ecological safety aspects].

The authors have analyzed the ecological, sanitary-and-hygienic and medicobiologic aspects of using the impoverished uranium in armaments and military equipment. The influence of impoverished uranium on human body (600 cases) was studied using medicobiologic investigation. It was shown that the particles of aerosol of mixed uranium oxide cause the radiation and chemical damage of kidneys, lungs and other internals. Uranium's alpha-radiation is very effective in induction of biologic effects during internal irradiation. Taking into account that bone tissue is the critical organ for uranium isotopes the medullar tissue is exposed to alpha-radiation. In the armed conflicts of the last decade wide use of armour-piercing means with elements consisted of impoverished uranium has led to the appearance of new technogenic risk factor for the environment and the man.

Bosnia and Herzegovina↗
PubMed2003

[Measures for psychological prophylaxis of the psychogenic adaptation disorders among flying personnel].

Adaptation disorders lie behind 70 to 80% of morbidity among and medical disqualification of flyers. Mental health is the hallmark of the psychoprophylaxis system defining its structural and methodical principles, and purpose. Counteraction to the psych dependent adaptation disorders requires consolidation of efforts of the services responsible for flyers professional health and flight safety; emphasis on motivation and social well-being of flyers is imperative.

Adaptation, Psychological↗
PubMed2002

In vitro response of mitochondrial succinate oxidase system to epinephrine in human blood lymphocytes from health individuals and patients with neurocirculatory dystonia.

Activities of succinate dehydrogenase (SDH) and alpha-glycerophosphate dehydrogenase (hyaloplasmic and mitochondrial: alpha-GPDHH and alpha-GPDHM) in peripheral blood lymphocytes, and the response of SDH activity to exogenous epinephrine in vitro (the epinephrine test) were studied in 20 healthy subjects and 46 patients with hypertensive neurocirculatory dystonia. Activities of SDH, alpha-GPDHH, and alpha-GPDHM in blood lymphocytes and SDH adrenoreactivity in epinephrine test were higher in patients than in healthy controls. Treatment with hypotensive agents (isradipin and pyrroxan) moderated adrenoreactivity. Phytotherapy normalized the baseline activities of succinate oxidase system and alpha-glycerophosphate pathway in blood lymphocytes.

Adult↗