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Biomedical subjects

I Altorjay

Publications and source records attributed to I Altorjay.

At least 37 records · Page 2Linked to original sources
PubMed1984

In vitro and in vivo demonstration of the cytoprotective effect of (+)-cyanidanol-3.

In vitro and in vivo investigations were undertaken to demonstrate cytoprotective effect of (+)-cyanidanol-3 on human erythrocytes. The time of full haemolysis induced by hydrochloride acid was measured and dynamic haemolysis curve was recorded with an aggregometer. In vitro, following a one-hour incubation of erythrocytes with (+)-cyanidanol-3 at 37 degrees C, significant increase of the haemolysis time could be demonstrated. The most expressive cytoprotective effect was observed at (+)-cyanidanol-3 concentrations of 2, 5 and 10 micrograms/ml. In vivo, two hours following the oral administration of 1.5 g Catergen, an increase of the haemolysis time for about 25% could be demonstrated. This simple method seems to be suitable for the investigation of the membrane stabilizing effect of (+)-cyanidanol-3.

Benzopyrans↗
PubMed1983

Saliva level of ethynylestradiol in presence of ethynodiol diacetate after oral administration.

In the presence of ethynodiol diacetate the ethynylestradiol concentration in serum and saliva after oral administration was measured by a rapid radioimmunoassay method developed by the authors. By means of the saliva/serum quotient, and from the concentration of ethynylestradiol in the saliva samples, it was possible to infer the ethynylestradiol content of the serum. Attention is called to the relation between the quotient and time, which should be taken into account when values are calculated. 2, 4 and 12 h after oral administration, the saliva/serum quotients for an ethynylestradiol dose of 0.05 mg were 0.27, 0.76 and 0.40, respectively.

Ethinyl Estradiol↗
PubMed1981

Congenital deficiency of cyclo-oxygenase in a woman with generalized atherosclerosis.

The case of a 52-year-old woman with congenital cyclo-oxygenase deficiency, signs of generalized atherosclerosis and a moderate bleeding tendency is reported. Secondary platelet aggregation was absent. Platelet aggregation induced by arachidonic acid failed totally while that induced by calcium ionophore was normal. No malondialdehyde formation could be detected in her platelet-rich-plasma. The life-long deficiency of cyclo-oxygenase had not protected her from progressive vascular disease. This case suggests that the chronic intake of large doses of aspirin cannot prevent arterial disorders.

Arteriosclerosis↗
PubMed1980

LDH isoenzymes in muscle diseases.

The LDH isoenzyme pattern was investigated in biopsy material of muscles of children suffering from progressive muscular dystrophy and other neurogenic muscular disorders. An absence or pronounced activity loss of LDH 5 was observable in most of the cases. The proportion of subunits was the same in the diseased and the control muscles. Comparing the measured isoenzyme patterns with those expected from a random coupling of of the subunits, a lower percentage of LDH 5 and a higher one of LDH 4 was detected. The cause of the absence of LDH 5 is not a disturbance of M subunit synthesis but the post-translational inhibition of the tetramer forming process of the synthetised M subunits.

Adolescent↗