Search PubMed⌕ Search

Biomedical subjects

I A Sytnik

Publications and source records attributed to I A Sytnik.

At least 19 recordsLinked to original sources
PubMed1978

[Combined action of aminoglycoside group antibiotics and bile acids on staphylococci].

The results of in vitro studies on the potentiating effect of cholic, taurocholic, glycocholic and desoxicholic acids on the bacteriostatic and bactericidal activity of aminoglycoside antibiotics are presented. Ten fresh isolates of staphylococci were used in the experiments. Sensitivity of the isolates to the antibiotics and bile acids and their combinations was determined by the method of serial dilutions. Investigation of the combined effect of gentamicin, monomycin, kanamycin and neomycin with the bile acids showed that all of them had potentiating effect on the antimicrobial activity of the antibiotics. The potentiating effect of different acids and antibiotics was not the same. The highest potentiating activity was observed with the use of gentamicin or neomycin in combination with desoxycholic and cholic bile acids. Desoxycholic acid increased the bacteriostatic activity of gentamicin and neomycin by 781.3 and 2083.3 times respectively and cholic acid increased it by 382.7 and 2083.3 times. Cholic and desoxycholic acids potentiated also the bactericidal effect of gentamicin and neomycin. Taurocholic and glycocholic acids produced potentiation of various antibiotics by 8 to 60 times.

Aminoglycosides↗
PubMed1978

[Bacteriostatic and bactericidal action of bile acids and antibiotics on staphylococci].

It was found in vitro that desoxycholic, cholic, glycocholic and choleinic acids inhibited the growth and development of staphylococci. The staphylococci isolated from bile were more resistant to the bacteriostatic and bactericidal effect of bile acids than the microorganisms isolated from other sources not containing cholates. Under the effect of these substances the activity of some antibiotics especially those from the group of aminoglycosides markedly increased.

Anti-Bacterial Agents↗
PubMed1977

[Combined action of benzylpenicillin and bile acids on staphylococci].

The antimicrobial effect of benzylpenicillin in combination with bile acids on staphylococci was studied. It was shown that bile acids increased the bacteriostatic and bactericidal effects of the antibiotic. The highest potentiating effect was found with combination of benzylpenicillin and desoxycholic and choleic acids. When resistant strains of staphylococci were exposed to the combination of the bile acids and benzylpenicillin they became highly sensitive to antibiotic.

Bile Acids and Salts↗
PubMed1975

[Joint action of nitrofuran preparations and bile acids on bacteria of the genus Proteus].

Sensitivity of 25 fresh isolates of Proteus to some nitrofuran drugs most widely used in the clinical practice, such as furacillin, furagin, furazolidone and nitrofurantoin was studied. When the drugs were used in combination with some bile acids, i.e. desoxycholic, dehydrocholic, cholic and glycocholic acids, significant in vitro potentiation of the antibacterial activity of the nitrofurans against the isolates was observed. The combinations of the drugs with desoxycholic acid proved to be most effective. In the presence of this acid the bacteriostatic dose of the drugs decreased several thousand times. Combination of the nitrofurans with the other acids resulted in an increase in the antimicrobial activity amounting to several hundred times. The combinations of the drugs with the bile acids had not only bacteriostatic but also bactericidal effect.

Bile Acids and Salts↗
PubMedDate not supplied

[Action of microbe-antagonists on bacilli and corynebacteria of the skin of the breast in nursing women].

Five microbes-antagonists are studied for their inhibitory action on 769 strains of bacilli (241) and corynebacteria (528) isolated from the mammary gland skin of 120 nursing women on the 2nd-5th day after labour. Escherichia coli M-17 and Mycococcus krassilinikovi are established to possess the highest antagonistic properties against the spore-bearing aerobic and coryneform bacteria. Bifidobacterium bifidum has exerted a moderate antagonistic action on the culture under study, Bacillus subtilis has exerted a strong inhibitory action on corynebacteria. B. licheniformis has slightly inhibited the both bacterial groups.

Antibiosis↗