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Biomedical subjects

I A More

Publications and source records attributed to I A More.

At least 55 records · Page 3Linked to original sources
PubMed1981

Electron microscopy in the long-term follow-up of Whipple's disease. Effect of antibiotics.

The electron-microscopic and light-microscopic findings on jejunal biopsies from a case of Whipple's disease are described. Seven biopsies were obtained over a 3-year period. Rapid clinical recovery was accompanied by the disappearance of interstitial and intracellular bacteria from the lamina propria. The pathognomonic PAS-positive material on light microscopy corresponding to the phagocytic vacuoles in the macrophages of the lamina propria decreased markedly in amount but persisted throughout the 3-year-period. The sequential changes in the jejunal mucosa and in particular those occurring in macrophages are described and their relation to pathogenesis is discussed.

Adult↗
PubMed1980

Adult pulmonary cytomegalic inclusion disease: report of a case.

A case is presented of pulmonary cytomegalic inclusion disease in adult. The condition was only diagnosed post mortem. A detailed description of the inclusions and inclusion-bearing cells is given. Histochemical observations which reveal an outer and inner zone to the intranuclear inclusion body are confirmed. Electron microscopy shows the viral basis of the infection. The morphology of the virus particles is compatible with a herpesvirus infection.

Cytomegalovirus↗
PubMed1980

Liver disease in rheumatoid arthritis.

Patients with active rheumatoid arthritis frequently have hepatosplenomegaly and biochemical features of hepatic disease. A prospective study with liver biopsy has been carried out in a series of 31 rheumatoid arthritis patients with clinical and/or biochemical evidence of hepatic dysfunction. Four of the 31 (13%) were found to have definable chronic liver disease, normal hepatic histology or non-specific reactive changes being found in the remainder. In the large majority of patients the hepatic abnormality in rheumatoid arthritis remains functional and unexplained.

Anti-Inflammatory Agents↗
PubMed1980

Atypical cilia of the human endometrial epithelium.

We suggest that human endometrial ciliated cells represent a developmental overlap with the uterine tube epithelium and that the high incidence of ciliary abnormality is related to the relatively high turnover rate caused by menstruation. Abnormal cilia appear to be due to a defect of ciliogenesis probably occurring after the formation of the basal bodies.

Adult↗
PubMed1979

Brain damage complicating septic shock: acute haemorrhagic leucoencephalitis as a complication of the generalised Shwartzman reaction.

The neuropathological findings in six patients who developed neurological signs after the onset of "septic shock" caused by Gram-negative septicaemia are described. The changes in the brains were characteristic of acute haemorrhagic leucoencephalitis, and there was evidence, particularly in the kidneys, of disseminated intravascular coagulation with tubular necrosis and, in some, appearances indistinguishable from membrano-proliferative glomerulonephritis. It is agreed that acute haemorrhagic leucoencephalitis is another manifestation of a generalised Shwartzman reaction, and it is suggested that activation of complement is the final common pathway that produces tissue damage in the brain and kidney.

Adult↗
PubMed1978

Branching microvilli in the nasal respiratory epithelium.

In an ultrastructural study of the respiratory epithelial covering of 14 human nasal mucous polyps, some of the microvilli overlying the ciliated cells were shown to exhibit a complex form of branching with a resultant increase in surface area. This apparently original observation is of uncertain significance but is not of definite pathological significance.

Cell Membrane↗
PubMed1977

A reappraisal of the ultrastructure of the human respiratory nasal mucosa.

A study of the ultrastructure of human respiratory nasal mucosa using specimens of simple mucous polyps showed features essentially identical to those described in the lower respiratory tract. Minor forms of epithelial specialization seen in the nasal lining of the other mammalian species are not demonstrable in man. Inflammatory cells, especially lymphocytes, form an integral constituent of the epithelium, and are in close apposition to the epithelial cells. A marked increase in the epithelial surface area is achieved through ridging and clefting, irregularity of the cell's surface and the presence of microvilli. Branching microvilli are admixed with more conventional structures.

Basement Membrane↗
PubMed1976

Ultrastructure of the stroma of nasal polyps: cilia in stromal fibroblasts.

Ultrastructural examination of the stroma of simple nasal polyps was shown that there is an edematous framework of fibroblasts with abundant interdigitating cytoplasmic processes, a plexus of inflamed blood vessels, and a mixed infiltrate of active inflammatory cells. Solitary cilia were seen to arise from the stromal mesenchymal cells; no mycoplasma or viral inclusions were present. These features may have a relationship to the pathogenesis of nasal polyps. An immunologically induced liberation of vasoactive amines from mast cells results in increased capillary permeability and a consequent excess of intracellular fluid; the stromal cells attempt to check this expansion by an increase in collagen synthesis.

Basement Membrane↗
PubMed1976

Amyloid deposits in the trachea and esophagus ultrastructural confirmation.

The clinical details of two patients suffering from amyloid infiltration of the trachea and esophagus respectively are presented. The "amyloid tumor" in the trachea presented with dysphonia and a swelling in the lower subglottic region. Attempts at complete surgical excision of it were unsuccessful. The patient with esophageal amyloid presented acutely with dysphagia and features of dehydration and malnutrition. Systematized amyloidosis was discovered at autopsy, but no primary initiating cause for it was found. In both cases it was possible to confirm the diagnosis by electron microscopy. The current views on the composition, structure, causation and treatment of amyloid disease are reviewed.

Aged↗
PubMed1976

The role of oestrogen in the control of ciliated cells of the human endometrium.

The incidence of ciliated cells in the human endometrium was determined. Conditions associated with an excess of oestrogenic activity were characterized by an increased incidence of ciliated cells, whilst oestrogen deficiency was associated with decreased numbers. When endometrium was cultured, addition of oestradiol-17 beta caused an increase in the ciliated cell population.

Adolescent↗
PubMed1975

The cyclical variation in the percentage of ciliated cells in the normal human endometrium.

The percentage of ciliated cells in the luminal and glandular epithelia of endometrial samples from sixty-eight normal women has been studied. Although the concentration of ciliated cells found in the luminal epithelium tended to lag behind and below those found in the glandular epithelium, no significant difference was found between the absolute percentages of ciliated cells in each site. The number of ciliated cells increased during the proliferative phase to reach a maximum of around 20%. This was maintained during the ovulatory phase, and then declined. The hormonal basis of this variation is discussed.

Adolescent↗
PubMed1975

The fine structure of the human endometrial ciliated cell.

Sixty-eight histologically normal specimens from all stages of the menstrual cycle were examined during an ultrastructural study of the human endometrial ciliated cell. The 'clear' ciliated cells found initially were seen to become at first dense and then secretory. These changes are advanced as an explanation to account for the previously observed reduction in frequency of the ciliated cell during the luteal phase. The possibility of an hormonal control mechanism is discussed.

Adolescent↗
PubMed1975

Ultrastructural aspects of infertility.

Organ culture studies have demonstrated that 17beta oestradiol can cause the rapid deterioration and dissolution of pre-existing nuclear channel systems in the human endometrial glandular cell. The importance of the nuclear channel system in implantation is emphasized and the implications of secretory activity in the endometrium of an infertile woman are discussed.

Adult↗