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Biomedical subjects

H Zeumer

Publications and source records attributed to H Zeumer.

At least 91 records · Page 5Linked to original sources

[Early prognosis of cerebral haemorrhage in premature infants with birth weights less than 1500 g. A clinical and computed tomographic study (author's transl)].

22 premature infants with a birth weight less than 1500 g were studied by computed tomography. All of them needed intensive care therapy and had symptoms, which may have been caused by cerebral haemorrhage. In 15 cases (= 68%) we found subependymal and intraventricular bleeding. Clinical data showed that ventilated premature infants with subependymal and intraventricular haemorrhage needed respiratory support in the first hours p.p. because of hyaline membrane and aspiration syndroms. Premature infants without cerebral haemorrhage were ventilated much later (mean 96 h. p.p.). All patients with intraventricular haemorrhage and ventricular enlargement with and without parenchymal haemorrhage (grade III and IV) died. Prematures with subependymal haemorrhage (grad I) and intraventricular haemorrhage without ventricular dilation (grade II) may survive, depending on eventually present pulmonary complications. The introduction of computed tomography in the examination of the CNS on prematures can therefore help to give an early prognosis.

Birth Weight

[Cranial computerized tomography of neonatal encephalopathies. Initial and follow-up studies (author's transl)].

60 premature and newborn infants with clinical evidence of hypoxia or traumatic encephalopathy were examined by cranial computerized tomography (CCT) during the first fortnight of life and their findings compared with those of a "control group", consisting of 7 infants with malformations. 48 patients showed pathologic findings in the initial CCT. With regard to type, topography and extension, two groups with two subgroups could be outlined: 1. lesions with low density due to hypoxic-necrotizing alterations. a) Bilateral in the white matter around the frontal and occipital horns of the lateral ventricles in both, premature and fullterm newborn infants. b) Corresponding to vascular distribution, focal or global, involving both gray and white matter in both, premature and newborn infants. 2. lesions with high density due to hemorrhages. a) Subependymal and intraventricular, mainly in asphyxiated premature infants. b) Subdural and intracerebral, probably of traumatic origin, involving premature and fullterm newborn infants. The morphological findings in the initial CCT were compared with the outcome in each case. Thus, it was possible to distinguish certain morphological patterns significantly associated with prognosis. 14 patients (23.3%) died in the newborn period. The surviving 46 children (76.7%) were at least once re-examined by CCT and followed up during 6-24 months. 16 patients (26.7%) had a normal development. 12 (20%) showed developmental retardation. 18 (30%) suffered from neurological sequela. Frequently the early follow-up CCT showed characteristic patterns. We believe, that the great number of pathologic findings with essential information warrant the application of CCT in premature and fullterm newborn infants with persistent neurological signs. Perhaps our CCT observations will lead to the consequence of a more controlled high care regimen.

Brain Diseases

Predominant white matter involvement in subcortical arteriosclerotic encephalopathy (Binswanger disease).

Fifteen of 605 examinations of patients aged 60 to 85 years showed symmetrical white matter hypodensity on computed tomography (CT). Six of these showed severe white matter hypodensity, low grade atrophy, and dilated ventricles. A diagnosis of encephalopathia subcorticalis chronica progressiva, or Binswanger disease, featuring the typical clinical course of neurological and psychiatric symptoms was reached. In one case, the diagnosis was confirmed by postmortem anatomopathological findings. The etiology is considered to be vascular and to represent a special course of arteriosclerosis. In some elderly patients, both white and gray matter involvement is seen on CT, but white matter hypodensity is not a common finding in severe vascular brain atrophy.

Aged

[Herpes-simplex-encephalitis: a computertomographic and electroencephalographic study (author's transl)].

The development of one case of proved necrotising Herpes-simplex encephalitis (Herpes-virus hominis Typ I) will be demonstrated with the help of daily encephalographic and 5 computertomographic studies. After the appearance of periodic complexes in the EEG there could be noticed with a difference of 24 hours a beginning and further on a progressive blurred hypodensity in the CT. The maximum of the periodic activity in the EEG exactly correlated to the beginning and later expansion of the anatomo-pathological changes. No expansion of the periodic activity could be registered in other areas of the brain. Yet there was spontaneous periodic activity in different brain areas, where new regions of hypodensity would be found in the CT. The additional appearance of new periodic complexes with different localisation and the demonstration of new hypodensities in the CT during the therapy of a Herpes-simplex-encephalitis must be valued as a bad prognosis of the illness.

Adult

[Computertomographical details of neurological syndromes in the newborn period (author's transl)].

57 premature and full-term newborn infants suffering from a perinatal asphyxia were neurologically and computertomographically examined during their first two weeks of life. No pathognomonical morphological patterns were found comparing the neurological syndromes with the computertomographic results. However, characteristical morphologic findings were obtained related to gestational age and typical neurological syndromes of the newborn period. The cranial computerized tomography permits in many cases a localized topical diagnosis and early prognosis. These morphological findings can have therapeutical consequences.

Asphyxia Neonatorum

[Computerized tomography in neurodegenerative diseases in childhood (author's transl)].

The early diagnosis of neurodegenerative diseases in childhood is of great interest for genetic counseling. The development of cranial computerized tomography (CCT) has led to an improvement in the recognition of progressive neurological disorders. On one hand CCT is of importance in distinguishing the neurodegenerative diseases from perinatally acquired cerebral lesions. On the other hand CCT permits the differentiation from degenerations of cerebral gray and white matter. In this connection repeated controls with CCT are of great significance. 4 characteristic case studies are described.

Brain Diseases

[The significance of cranial computerized tomography for diagnosis and therapy of inflammatory diseases of the brain and meninges in children (author's transl)].

The significance of cranial computerized tomography (CCT) for the diagnosis and therapy of inflammatory diseases of the central nervous system in children is discussed in connection with five characteristic case studies. CCT is shown to be superior to classical neuroradiological approaches, and to allow important diagnostic insights: 1. the early recognition of diffuse brain edema and the resulting possibility of an early begin of therapy--2. the pathological expansions of the cerebral ventricles of various etiology before a pathological enlargement of the head can be detected, and the size of the ventricles after neurosurgical therapy can be measured--3. the early recognition of space-occupying inflammatory complications.

Brain Abscess

[Technical realization of a systematized radiation therapy, founded on the TNM system, of tumors in the regions of the head and neck (author's transl)].

Modern radiation therapy of tumors within the regions of the head and neck regards not only the concept of the target volume but also the probability of affection to the lymphatic chains. Frequency of spread to lymph nodes depends on the size of the primary tumor, and thus the extent of radiotherapeutic practical measures can be conformed to the TNM system. A radiation therapy planned in view of the TNM classification may be termed, therefore, as a systematized radiation therapy. From the standpoint of these considerations irradiation techniques using a telecobalt therapy unit and a betatron have been examined considering the application to individual toumor sites and tumor volumes in the regions of the head and neck. The techniques being most appropriate for tumors of the head and neck, with regard to the various sites or volumes, and taking into account the target volume as well as the lymphatic chains concerned are here presented.

Cobalt Radioisotopes

[Results of angiographic investigations in basilar artery insufficiency (author's transl)].

Angiographies were performed in 75 selected patients with basilar artery insufficiency. In only one case was there an indication for vascular surgery to the vertebral artery, and in two cases for an uncoforaminectomy, whereas in 13 cases prophylactic desobliteration of the internal carotid artery was performed. Thus vascular surgical consequences of angiography of the supraaortic vessels in basilar insufficiency are minimal. However, personal observations and reports in the literature indicate that the indications for surgery to the vertebral artery or the cervical spine will increase if functional investigations can be performed in various positions of the cervical spine by means of selective catheter angiography.

Basilar Artery

[Main signs of neurologic disease during pregnancy (author's transl)].

The most important neurologic diseases which may start during pregnancy are described. On the basis of clinical, easily discovered, signs the essential differential diagnosis and specific diagnostic techniques (electromyography, electroneurography, angiography, computotumography) and their indications are outlined. In some detail prognosis and indications for common diseases (epilepsy, M.S.) are discussed. Treatment of those diseases is especially considered in which emergency drug therapy may be needed.

Brain Neoplasms

[The value of xerotomography in the radiologic diagnosis of chronic cervical myelopathy (author's transl)].

Report on experience with radiologic diagnosis of 13 patients with chronic cervical myelopathy, who were examined at our clinic within 6 months. The various neuroradiologic findings are described and evaluated as to their causal importance. If plain radiograms show a spinal canal of normal diameter and where there are no multiple osteochondrotic changes, examinations with positive contrast media are most suitable. Air myelograms should be used when the advantages of xerotomography can be made use of.

Chronic Disease

[Doppler ultrasonic diagnosis of the subclavian-steal syndrome (author's transl)].

It is possible to perform percutaneous Doppler ultrasonic flow measurements in the vertebral artery below its curvature over the atlas. Criteria supporting the subclavian-steal syndrome are (I) red side, (2) slowing of blood flow in the vertebral artery after compression of the axillary artery on the same side, and (3) delayed pulse in the axillary artery of the diseased compared with the normal side.

Humans

Application of xeroradiography for pneumencephalography.

The feasibility of xerotomography with pneumencephalography is demonstrated. One of the advantages of a xerotomogram is that it reduces the lack of sharpness caused by tomography. The wide recording latitude of a xerotomogram makes a more detailed evaluation of the bone structure and the outlines of the soft tissue possible when these are contrasted be means of air. The characteristic edge effect of a xerogram also facilitates better detection of the small structures which are less well discerible on a film tomogram.

Brain Neoplasms

[Nonaneurysmal vascular pressure lesions of the cranial nerves (author's transl)].

Four cases of facial spasm and 1 case of oculomotor paresis are described. The source of the disorder in all 5 cases is mostlikely not an aneurysm of the vessels of the base of the brain. The literature is discussed and thereby it is shown that mechanical disturbances of other cranial nerves (II, V, VI, IX, XII) can be caused by similar vascular (nonaneurysmal) abnormalities.

Aged

Planigraphic measurement of angiograms and pneumencephalograms in the diagnosis of hydrocephalus.

Instead of the usual descriptive criteria commonly adopted for angiographic assessment of hydrostatic hydrocephalus, planimetric measuring methods were tried out. It was shown that the surface area under the anterior cerebral artery (pericallosal) as measured in the lateral angiogram increases proportionally to the volume of the cella media. A high degree of conformity was shown between the clinical and descriptive neurological findings and the planimetrically obtainable values.

Cerebral Angiography

[Paradoxical embolism with preferential localisation to the cerebral vessels].

Massive paradoxical embolism with cerebral symptoms developed at 30 hours after abdominal hysterectomy in a 53-year-old woman. An essential condition for the occurrence of paradoxical embolism is an increased pressure in the lesser circulation; the most frequent cause is massive pulmonary embolism which, however, may take a relatively mild course if there is adequate right to left shunting. The absence of clinical signs of pulmonary embolism does not exclude systemic venous thrombosis as the site or origin of peripheral arterial emboli.

Blood Pressure

[Fibromuscular dysplasia of the internal carotid and intracerebral arteries (author's transl)].

Fibromuscular dysplasia was found in six patients (four women over 50 years, a 20-year-old man and a five-year-old girl). Angiography (in five cases performed because of a cerebrovascular accident) gave the typical appearance of "knotted string" changes in the large and medium sized arteries. With marked localized arterial narrowing treatment is surgical. Conservative treatment remains sympotomatic because the cause of the disease is still unknown. Even surgical treatment brings only sympotomatic relief and, because of the slowly progressive nature, is indicated only when there are neurological signs.

Adult