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Biomedical subjects

H Zeidler

Publications and source records attributed to H Zeidler.

At least 181 records · Page 10Linked to original sources
PubMed1987

Undifferentiated arthritis and spondylarthropathy as a major problem of diagnosis and classification.

Epidemiologically-based studies have shown that 20-50% of all cases of early arthritis cannot be classified. More recent data came from experiences with an outpatient clinic especially for early arthritis. Of 149 patients with inflammatory rheumatic disease, 39 (26%) were diagnosed as undifferentiated arthritis and 22 (15%) had a probable diagnosis. Therefore, despite diagnostic progress in recent years, only half of all cases can be diagnosed definitely. Follow-up studies of patients with HLA-B27 positive arthritis and undifferentiated spondylarthropathy show the difficulties of early diagnosis and the heterogeneity of disease course and prognosis. Early diagnostic criteria combining the result of the HLA-B27 test with history, symptoms, erythrocyte sedimentation rate and radiological spinal signs can predict or exclude the development of ankylosing spondylitis (AS) at an early stage of the disease in three-quarters of patients, but the diagnosis of AS should not be excluded before 5 to 10 years' observation.

Arthritis↗
PubMed1986

Studies on the SV40-like papovavirus SV40-GBM. III. Propagation at low multiplicities of infection in various human cell lines.

At low multiplicity several human cell lines supported the lytic infection with SV40-GBM better than that with the wild type SV40. The efficiency of viral DNA replication differed in the cell lines used suggesting that specific host cell factors may determine the rate of viral DNA synthesis. Furthermore, the emergence of different DNA defects during propagation of the virus indicates that host cell factors in question might also influence the composition of the viral DNA population.

Cell Line↗
PubMed1986

Clinical features of inflammatory joint and spine manifestations in Crohn's disease.

167 patients with Crohn's disease were investigated for joint and spine inflammation. Arthritis was observed in 23 patients (14%), sacroiliitis in 24 (14%), and sacroiliitis in combination with arthritis in 11 patients (7%). 15 patients (9%) had ankylosing spondylitis; 9 of them were HLA-B27 positive (60%). A parallel pattern in the course of bowel disease and joint inflammation was observed in 22 out of 34 patients with arthritis (59%). An association between the localization of Crohn's disease and the type of spondylarthritis could not be demonstrated. Patients with arthritis alone developed erythema nodosum (35%) or aphthous stomatitis more often (21%) than patients without spondylarthritis+ (6% and 12%, respectively). Other extra-intestinal manifestations of Crohn's disease did not reveal any association with the development of spondyloarthritis.

Adolescent↗
PubMed1985

[Synovitis in familial Mediterranean fever].

Arthroscopy done on a 24-year-old turkish male with familial Mediterranean fever (FMF) and arthritis of the knee joint provided morphological data during the acute stage of FMF-arthritis. Main finding is a heavy granulocytic infiltration of the subsynovial stratum, similar to that seen in non-specific purulent inflammation, accompanied by marked ectasis and hyperaemia of the synovial vessels. In the microbiologically sterile synovial fluid cell counts and lactate values are found as in bacterial arthritis. The typical history and the characteristic course of the disease are indicators for the diagnosis. Serological, immunological and radiological findings are non-specific. The efficacy of prophylactic colchicine in symptomatic therapy could be verified but it is essential that the drug is taken regularly and that the patient is instructed accordingly. Investigation of other members of the family showed a high frequency of intermarriages and the presence of this autosomal-recessive inherited disease in three generations.

Adult↗
PubMed1984

[Experiences to date with oral gold therapy].

Auranofin is the first oral gold therapy known to be effective at relatively low toxicities. Extensive clinical trials in rheumatoid arthritis have recently been complemented by first experiences in juvenile chronic polyarthritis. For the time being, the drug should, therefore, be confined to these conditions. It is not indicated in ankylosing spondylitis and in other seronegative arthropathies. Indications mainly include failure of antimalarials, early erosive arthropathies and contraindication of injection therapy. The drug may also be used as an alternative to intramuscular gold, but should not be administered to responders to other chronic antirheumatics and in late or end-stage disease.

Adult↗
PubMed1983

Circulating immune complexes in ankylosing spondylitis.

Circulating immune complexes were determined in the sera of patients with ankylosing spondylitis using a polyethylene glycol precipitation laser nephelometer technique. Positive results were obtained in 52% of sera from patients with active disease, but only in 20% from those in inactive stages. The immunoglobulin/complement protein ratio differed from that seen in rheumatoid arthritis and in systemic lupus erythematosus, due to the relatively larger amounts of C3 and C4 present in the immune complexes. These findings indicate that circulating immune complexes in ankylosing spondylitis may not be of pathogenetic significance because of their degree of solubilization.

Antigen-Antibody Complex↗
PubMed1982

Characterisation of blood and synovial fluid lymphocytes from patients with rheumatoid arthritis and other joint diseases by monoclonal antibodies (OKT series) and acid alpha-naphthyl esterase staining.

Mononuclear cell preparations from peripheral blood (PBL) and synovial fluid (SFL) of 27 Patients with rheumatoid diseases (15 patients with definite rheumatoid arthritis (RA), 10 with other inflammatory joint diseases (OJD), 1 with sarcoid arthritis (SA) and 1 with traumatic arthritis (TA) were examined for lymphocyte subpopulations determined by monoclonal antibodies of the OKT series and by the dot-like, acid alpha-naphthyl esterase staining (ANAE) activity. In patients with classic, active RA, blood T cells carrying the OKT8+ (suppressor/killer) phenotype were significantly reduced leading to an elevated OKT4/OKT8 ratio of 4.1 +/- 0.4 compared with 2.1 +/- 0.1 in healthy controls. In 10 patients with OJD this diminution of OKT8+ cells in peripheral blood was less pronounced or absent. As regards SFL subpopulations, patients with RA and OJD exhibited a similar distribution pattern with an elevation of OKT8+, Ia+ and ANAE negative cells and a similar OKT4/OKT8 ratio of 1.5 +/- 0.3 and 1.6 +/- 0.4, respectively. Similar results were also obtained in the only patient with TA, whereas the patient with SA and one RA patient with relapse after surgical synovectomy exhibited high OKT4/OKT8 ratios, both in synovial fluid and peripheral blood. Neither the OKT markers nor the dot-like ANAE staining pattern were significantly correlated to parameters of systemic or local disease activity as estimated by erythrocyte sedimentation rate and a local disease activity index.

Adolescent↗
PubMed1982

HLA-B27 in possible ankylosing spondylitis with peripheral arthritis.

Among 86 patients selected as possibly having ankylosing spondylitis because of clinical symptoms and radiologically normal sacroiliac joints. HLA-B27 was positive in 41%. Four years later a representative sample of 38 individuals were re-examined and radiographed. HLA-B27 positive patients developed sacroiliitis as defined by radiological criteria twice as often (P less than 0.05). They also showed increased uptake of technetium 99 m upon quantitative scintigraphy with a region of interest method and more often probable or definite ankylosing spondylitis as defined by the New York criteria. Further differences between the HLA-B27 positive and negative follow-up groups concerned the frequency of clinical symptoms and peripheral arthritis. It is suggested that HLA-B27 typing may be helpful both in diagnosis and in judging the prognosis of possible or abortive ankylosing spondylitis.

Adult↗
PubMed1981

[Histopathology of nephroblastomas (author's transl)].

Nephrectomy specimens from 42 patients with nephroblastoma were investigated. With the exception of one specimen (the patient had been treated preoperatively), all of the tumors were suitable for grading procedures. When the tumors were classified by the grading procedure of Lawler et al. (1975), the moderately tubulus-rich type++ was the most common (22 out of 41 patients). When the classification of Beckwith and Palmer (1978) was applied, the mixed type of nephroblastoma dominated correspondingly (19 out of 41 patients). Patients with an increased risk can be identified particularly well with the classification of Beckwith and Palmer. The following histologic features are indications of an unfavourable prognosis: focal or diffuse "anaplasia" of the tumor tissue, or a sarcomatous component in a stroma-rich nephroblastoma. The children with sarcomatous nephroblastoma (5 patients) were remarkably young (the oldest was 16 months of age), whereas the children with anaplastic nephroblastoma (3 patients) were much older (62, 67, and 72 months). In five children equivalents of the nephroblastomatosis complex (nodular renal blastema in all 5 patients, sclerosing metanephric hamartoma in 2 patients, and Wilms' tumorlet in one patient) were found in the non-infiltrated tissue of the same kidney.

Age Factors↗