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H Z Li

Publications and source records attributed to H Z Li.

48 records · Page 3Linked to original sources
PubMed1988

[Pathological findings and prognosis in 202 patients with small cell lung cancer].

This paper presents the pathological findings of small cell carcinoma of lung of 202 patients treated by surgery in our department from 1957 to 1984. Small cell lung cancer comprises 15.7% of all lung cancers. Gross type: central type was 67.3% and peripheral type was 32.7%. According to the histological classification system for lung tumor, WHO, 1981, small cell carcinoma is divided into three subtypes: (1) oat cell carcinoma (118 cases), (2) intermediate cell type (55 cases), and (3) mixed oat cell carcinoma (29 cases). Electronic microscope examination was done in 3 cases. Neurogenic secretory bodies in the cytoplasm were found in 2 oat cell carcinoma, but not in the other intermediate cell type. The 5-year survival rate of small cell carcinoma was 22.4% among whom four survived over ten years. The 5-year survival rate of oat cell carcinoma, intermediate cell type and mixed oat cell carcinoma were 19%, 34.8% and 9.1%, respectively. The intermediate cell type was the best in the 3 types. The 5-year survival rate of the peripheral type was 30.4% which was higher than that of the central type (18.9%). The 5-year survival rate was 30.8% in patients without metastasis to the lymph nodes in the hilus or mediastinum, and 18% in those with metastasis. There were no differences in the prognosis of those whether the pleura were involved or the resection stump was positive.

Adult↗
PubMed1983

Immunocytochemical localization of L-glutamate decarboxylase, gamma-aminobutyric acid transaminase, cysteine sulfinic acid decarboxylase, aspartate aminotransferase and somatostatin in rat retina.

The regional distribution and cellular location of GABA-synthesizing enzyme, L-glutamate decarboxylase (GAD), GABA degrading enzyme, GABA-transaminase (GABA-T), taurine synthesizing enzyme, cysteine sulfinic acid decarboxylase (CSAD), aspartate and glutamate converting enzyme, aspartate aminotransferase (AAT), and somatostatin have been visualized in the rat retina by immunocytochemical methods. GAD immunoreactivity was found to be concentrated in the inner plexiform layer. A moderate to weak staining of GAD was found in the inner nuclear layer. The distribution of GABA-T immunoreactivity was similar to that of GAD with the exception that a weak to moderate staining of GABA-T was also observed in the outer plexiform layer. CSAD immunoreactivity was seen in every layer with the heaviest staining in the inner plexiform layer, and moderate staining in the inner and outer nuclear layers and ganglion cell layer. AAT immunoreactivity was mostly concentrated in the outer nuclear layer; there was weak staining in the inner nuclear layer and inner and outer plexiform layer. Dense somatostatin staining was seen in the inner plexiform layer and moderate staining was present in the inner nuclear layer, outer plexiform layer and ganglion cell layer. These findings suggest that in rat retina, GABA-containing cells occur in some types of amacrine cells only, while taurine and somatostatin appear in both amacrine and horizontal cells. AAT immunoreactivity was primarily associated with the photoreceptor cells suggesting that AAT may be used as a marker for aspartergic/glutamergic cells and their endings in the central nervous system.

4-Aminobutyrate Transaminase↗
PubMedDate not supplied

Histamine excites rat cerebellar granule cells in vitro through H1 and H2 receptors.

The effects of histamine on the firing of cerebellar granule cells were investigated in vitro. Histamine predominantly produced excitatory (117/123, 95.1%) and in a few cases inhibitory (6/123, 4.9%) responses in granule cells. The histamine-induced excitation was not blocked by perfusing the slice with low Ca2+/high Mg2+ medium, supporting a direct postsynaptic action of histamine. The H1 receptor antagonists triprolidine and chlorpheniramine significantly diminished the histamine-induced excitation, but the H2 receptor antagonist ranitidine did not significantly reduce the excitation. On the other hand, the H2 receptor agonist dimaprit could elicit a weak excitation of granule cells. This dimaprit-induced excitation was blocked by ranitidine but not triprolidine. These results reveal that the excitatory effect of histamine on cerebellar granule cells is mediated by both H1 and H2 receptors with a predominant contribution of H1 receptors. The relevance of these findings to the possible function of the hypothalamocerebellar histaminergic fibers in cerebellum is discussed.

Animals↗