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Biomedical subjects

H Yano

Publications and source records attributed to H Yano.

At least 469 records · Page 26Linked to original sources
PubMed1985

The influence of protein and/or energy deficiency on the growth of long bone in rats.

The effects of protein and/or energy deficiency on long bone growth were studied using rats of an average weight 100g. Four groups of Wistar rats were respectively fed on a normal diet, a low-energy diet, a low protein-diet, and a low-protein and low-energy diet for 45 days. Both energy and protein deficiency restricted gains of body weight and femur length and the activity of alkaline phosphatase in the tibia to the same extent. The epiphyseal growth plates of the femur in protein-deficient rats were as thin as those in energy-deficient rats. On the other hand, femur width and activity of acid phosphatase in the tibia were lower in protein-deficient animals than those in energy-deficient ones. Serum calcium concentrations and calcium content of bone were the same among all groups.

Acid Phosphatase↗
PubMed1985

[Experience with induced hypertension chemotherapy for lung cancer].

Induced hypertension chemotherapy (IHC) using angiotensin II was applied for patients with lung cancer who had not been treated previously, and the results compared with those of preceding conventional chemotherapy as a sequential control. Twenty-nine patients with non-small cell lung cancer (non-SCLC) were treated with MTX and MMC. Response rate among evaluable cases was 23.1% (3/13) for conventional chemotherapy and 18.2% (2/11) for IHC. Twenty-eight patients with small cell lung cancer (SCLC) were treated with VCR, CPA and ACNU. Among evaluable cases, both chemotherapy groups with and without IHC showed the same response rate, 66.7% (8/12). With respect to response rate, there were no differences between conventional chemotherapy and IHC for non-SCLC or SCLC.

Adenocarcinoma↗
PubMed1985

Lung cancer in chromate workers--analysis of 11 cases.

We have experienced 11 cases of lung carcinoma in workers at a chromate factory during the past 14 years. All patients were males. The age of onset ranged from 41 to 68 years. Ten of the 11 were heavy smokers. The time of exposure to chromate was from 17 to 29 years and the average was 23.9 years. Seven patients had perforation of their nasal septa. The primary sites of the cancers were from the lobar to the subsegmental bronchi. There were nine squamous cell carcinomas and three small cell carcinomas. Four squamous cell carcinomas were hilar type early stage cancers and two of them were found in one patient at the same time. The chromium content of the lung tissue in the seven patients tested was from 13.9 to 2,368.4 micrograms/g of dry tissue and was higher than that of lung cancer or non-lung cancer cases without chromate exposure. There was no severe dysplasia of the bronchial epithelium in these 11 patients.

Adult↗
PubMed1985

[Adenosquamous carcinoma of the stomach].

The appearance of adenosquamous structures in cancer of the stomach was studied in 385 resected specimens. Such structures were observed in 9.1% of the specimens. However, they were not found in cases in which the invasion was limited to the mucosa. The frequency of the appearance increased in correlation with the extent of the cancerous invasion. The type of adenocarcinoma that coexisted with the squamous changes was the intestinal type of Lauren in 68% of the specimens. This indicates that the squamous structures, seen in gastric cancer result from secondary metaplasia of the intestinal type in this condition.

Adenocarcinoma↗
PubMed1984

The effects of progesterone on gonadotrophin release in hypogonadal women.

The effect of progesterone on pulsatile and basal release of gonadotrophins was studied in 10 hypogonadal women. The day before progesterone treatment, control blood samples were obtained at 15 min intervals between 15.00 and 20.00 h. The next day, 50 mg of progesterone was administered im at 06.00 h and blood samples again were obtained at 15 min intervals between 15.00 and 20.00 h. Serum progesterone levels were 28.4 +/- 4.4 ng/ml at 15.00 h, 24.2 +/- 3.9 ng/ml at 17.30 h and 20.7 +/- 2.5 ng/ml (mean +/- SD) at 20.00 h. Progesterone prolonged the interval between LH pulses from 85 +/- 27 to 155 +/- 55 min (mean +/- SD), augmented their amplitude 2-fold, and caused average declines in LH and FSH concentrations of 27 and 15%, respectively. The results suggest that progesterone suppresses the mean levels of LH and FSH concentrations by acting in the brain to decrease the pulse frequency of gonadotrophin-releasing hormone.

Adult↗
PubMed1984

Effect of calcitonin on salivary phosphorus and calcium excretion in sheep.

Three thyroidectomized sheep were infused intravenously with porcine calcitonin at a rate of 30 mi.u./h per kg and three sham-operated sheep were infused with vehicle for 5 h. Saliva was collected from the left parotid duct by cannulation for 10 min in every hour. Salivary secretion rates were not changed in either thyroidectomized or sham-operated sheep throughout the experiment. Before the infusion, salivary phosphorus excretion was less in thyroidectomized sheep than in sham-operated animals. Calcitonin infusion increased salivary phosphorus excretion and decreased serum phosphorus concentrations in thyroidectomized sheep. Vehicle infusion did not affect salivary phosphorus excretion in sham-operated sheep. Serum concentrations and salivary excretion of calcium were decreased by calcitonin infusion into thyroidectomized sheep but were not changed in sham-operated sheep infused with vehicle. Calcitonin infusion increased serum parathyroid hormone concentrations in thyroidectomized sheep after the decrease of serum calcium concentrations. However, vehicle infusion did not affect serum parathyroid hormone concentrations in sham-operated sheep. There was little change of cyclic AMP excretion during the experiment in either thyroidectomized or sham-operated sheep. It is concluded that calcitonin increases salivary phosphorus excretion in sheep.

Animals↗
PubMed1984

Effects of intravenous glucose or epinephrine injection on plasma concentrations of potassium, magnesium and insulin in sheep.

The experiment was conducted to study the relationships among glucose, insulin, potassium, magnesium and calcium concentrations in the blood plasma following intravenous glucose or epinephrine injection. Plasma concentrations of potassium and magnesium were lowered after the respective injection of glucose and epinephrine. When compared to epinephrine injection, an injection of glucose solution decreased potassium and magnesium concentrations in plasma more rapidly. Moreover, the recovery of the concentration levels of these minerals was faster when the animals were injected with glucose rather than epinephrine. These changes were inversely related to those of plasma insulin concentrations. The results may indicate that increased insulin secretion caused by glucose or epinephrine injection results in decreases of the plasma magnesium as well as potassium concentration in sheep.

Animals↗
PubMed1984

[Clinical evaluation of ceftizoxime in the treatment of complicated urinary tract infections].

Ceftizoxime (CZX) was given clinically to 80 patients with urogenital tract infections, in which 34 cases of complicated UTI satisfied the criteria of the UTI committee. CZX was administered for at least five days at a daily dose of 1 to 4 g in two divided doses by intravenous drip infusion. The overall clinical efficacy of CZX in 34 cases of complicated UTI was 59%, estimated by the criteria of the UTI committee. The overall clinical efficacy rate according to group of infection was: 64% for the 11 patients in the 1st group, 56% for the 9 patients in the 2nd group, 100% for the 5 patients in the 3rd group, 50% for the 4 patients in the 4th group and 20% for the 5 patients in the 5th group. No serious side effects were observed in the clinical or laboratory findings except for slight elevation in GOT & GPT values in two cases (2.5%), which returned to normal after CZX treatment. It is therefore suggested that CZX is a clinically useful and safe drug in the treatment of complicated UTI.

Adolescent↗
PubMed1984

[Chemotherapy after prostatectomy--effects of long term administration of Pivmecillinam (PMPC)].

The therapeutic efficacy of Pivmecillinam (PMPC) against urinary tract infections after prostatectomy was investigated. PMPC was orally administered at the dose of 300 mg/day for 2-14 weeks after initial intravenous postoperative chemotherapy with other antibiotics for 0-24 days (average 5.7 days). Thirty patients underwent retropubic prostatectomy and the other 59 patients received TUR-P. The chemotherapeutic efficacy for 19 patients who had over 10(3) CFU/ml of microorganisms was as follows: The effective rate was 48.4% after 2 weeks, 53.8% after 4 weeks, 66.7% after 5-6 weeks and 100% after 7-9 weeks. The prophylactic efficacy for 70 patients who had no or less than 10(3) CFU/ml of microorganisms was 64.3% after 2 weeks, 79.6% after 4 weeks, 86.7% after 5-6 weeks and 90.0% after 7-9 weeks. The overall clinical efficacy of PMPC for 89 patients was 60.7% after 2 weeks, 74.2% after 4 weeks, 83.3% after 5-6 weeks, 90.0% after 7-9 weeks and 100% after 10-14 weeks. No severe side effects were found in these 89 cases. In conclusion, PMPC is a useful drug for the long term treatment after prostatectomy.

Administration, Oral↗
PubMed1984

[Experience with psychotropic agents Pyrethia and Contomin in the terminal care of lung cancer patients].

Among patients with lung cancer, those having PS 4 ( Performance Status 4) and cancer pain received " Pyrecon ", a psychotropic agent, consisting of promethazine hydrochloride ( Pyrethia ) and chlorpromazine hydrochloride ( Contomin ). A mixture of 125 mg of Pyrethia and 50 mg of Contomin was diluted in 500 ml of regular IV solution and given through the central vein at a rate of 20 ml/hr. Pyrecon was found to be effective in patients with severe cancer pain in whom Brompton cocktail was ineffective. Pyrecon was also effective in patients whose daily life rhythm was unsteady due to insomnia caused by anxiety or unrest. We suggest that Pyrecon is effective in the treatment of cancer pain.

Adult↗
PubMed1983

Hepatobiliary scintigraphy after hepatic portoenterostomy.

Hepatobiliary scintigraphy with 99mTc-E-HIDA was carried out in 10 patients who had undergone hepatic portoenterostomy for "non-correctable" biliary atresia. In all the patients there was an active bile flow and disappearance of jaundice, post-operatively. Elimination of 99mTc-E-HIDA from the liver was slow during the first 3 post-operative months despite active bile flow and disappearance of jaundice. The elimination rate of the radioactive agent from the liver in most long-term survivors was comparable with findings in controls.

Bile Ducts↗