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H Yamagiwa

Publications and source records attributed to H Yamagiwa.

At least 37 records · Page 2Linked to original sources
PubMed1992

[Immunohistochemical study of the lymph-follicles and lymphocytes in the gastric mucosa].

Immunohistochemical stainings according to ABC method (UCHL-1,L-26,MT-1,MB-1,IgG,IgA,IgD,IgM, kappa, lambda, LN-1 and LN-2) for the lymphocytes in the germinal center, mantle zone and infiltrative lymphocytes in the gastric mucosa of 30 cases of chronic gastritis and 10 cases of reactive lymphoreticular hyperplasia (RLH) were performed. Lymphocytes in the germinal center and mantle zone consisted usually of B-cells positively stained by L-26 and MB-1. However, in the interstitially infiltrative cells,T-cells positively stained by UCHL-1 and MT-1 were not infrequently contained. Immunoglobulin stainings revealed marked positivity for IgG,IgA,IgD,IgM, kappa and lambda in the interstitial lymphocytes and plasma cells. As to the RLH, small number of T-cells scattered in the germinal center and surrounding area of lymph follicles, and large number of T-cells were found among the follicles, where B-cells were more infrequently found than in the interstitial area of propria mucosae. Confusion of enlarged germinal centers and monotonous proliferation of lymphocytes among the lymph follicles showing monotonous positivity for the stains of heavy and light chains in the cases of RLH were suggestive of malignant change.

Chronic Disease↗
PubMed1992

[Immunohistochemical study of EGF and EGF-R on the esophageal carcinomas--from a standpoint of depth of invasion].

We performed immunohistochemical stainings for epidermal growth factor (EGF) and epidermal growth factor receptor (EGF-R) on 63 resected esophageal carcinomas without preoperative treatment and 12 cases with preoperative radiation to clarify a relationship between positivity and depth of invasion. EGF and EGF-R showed a similar positivity (75% of early cases and 88.9% of advanced ones invaded beyond submucosa). In advanced carcinomas, the positivity in each layer was 75% in the mucosa, 86.7% in the submucosa and muscle layer, and 93.3% in the adventitia. All lesions of nodal metastases were positive for these stainings. Sixty % of cases with preoperative radiation were positive. The degenerated cells showed weak positivity. However, the viable cells showed similar positivity to those of non-treated cases.

Epidermal Growth Factor↗
PubMed1991

[Histological study of heterotopic pancreas tissue of the stomach--histogenesis and immunohistochemical findings].

Forty resected cases of heterotopic pancreas (15 of Heinrich's type I and 25 of type II) in the stomach were investigated. Acinic cells were more remarkably positive by pancreatic polypeptide and amylase in the cases of type I consisting of acinic cells, ducts and islet cells compared with those in type II consisting of acinic cells and ducts. Staining behavior by insulin, gastrin, glucagon, somatostatin and serotonin was similar to that of normal pancreas. However, the intestinal epithelium containing goblet cells and pyloric gland-like glands consisting of the cells with clear cytoplasm were not infrequently produced from the ducts in the lesions of type II. Muscle fibers with transition to muscularis mucosae were more frequently intermingled in the lesions of type II compared with type I. Acinic cell-differentiation in the mucosa apart from the main lesion was found in several cases of type II. It was suspected that there are two types of histogenesis for the heterotopic pancreas in the stomach; one arises from the fetal immigration of pancreas tissue in the stomach and the other from the immature gastric mucosal penetration into the submucosa with secondary differentiation to the pancreas tissue.

Choristoma↗
PubMed1991

[Histopathological study of resected esophageal cancers between with and without preoperative radiation therapy].

A histopathological study was performed on 53 radiated and 123 non-radiated resected esophageal cancers. The preoperatively radiated (3,000 to 4,000 rads) lesions were usually smaller than the non-treated ones due to the reduction in tumor tissue, and the incidence of infiltrative ulcerated type lesions (Borrmann 3-like) was markedly higher in the former. Histologically, the incidence of moderately-differentiated squamous cell carcinoma (SCC) was lower and that of well-differentiated SCC was higher in the radiated cases, probably due to the high sensitivity of the former type compared with the latter. The incidence of vascular involvement was lower in the radiated cases than the non-treated cases because of the reduction in vessel size due to fibrosis and scar caused by the radiation. However, lymph-nodal metastasis was more frequent in the radiated cases in which the more deeply invaded lesions were included compared with the non-treated cases.

Aged↗
PubMed1990

[Clinicopathological study of 65 cases of aberrant pancreas in the stomach].

Sixty-five cases of aberrant pancreas in the gastric wall in 9,650 resected stomach were investigated clinicopathologically. Average age was 44.5 and male to female ratio was 3.5 to 1. Eighty-eight per-cent of the lesions were found in the pylorus and antrum, and the lesions were frequently found in the posterior wall, anterior wall and greater curvature. The size of the lesions varied from 0.7 cm to 4.5 cm in diameter and 89.1% of them were within 3 cm in diameter. The protruded lesions were usually found in the space between submucosa and propria muscularis, and the flat-elevated ones were frequently found in the space between propria muscularis and subserosa. The histological incidence of Heinrich type I, II and III were 38.8%, 52.2% and 9.0%, respectively. There was no case of malignant change in the present series.

Adult↗
PubMed1990

[A clinicopathological study of signet-ring cell carcinomas of the stomach].

Surgically resected signet-ring cell carcinomas of the stomach have been clinicopathologically investigated. Although this type of carcinoma was found to be widely spread in the propria mucosa, a deeper invasion beyond the submucosa appeared more slowly than in other types of carcinomas. For example, the larger the early carcinoma in which the invasion was restricted to within the submucosa, the greater the incidence of a signet-ring cell carcinoma increase, especially in cases involving the mucosa. The incidence of a nodal metastasis was found to be lower than in cases of a moderately and poorly-differentiated adenocarcinoma in the early stage. However, when the signet-ring cell carcinomas invaded beyond the submucosa, the tumor cells spread rapidly and widely in the wall with a subsequent abdominal implantation, causing ascites and peritonitis carcinomatosa. It seemed likely that this deep invasion was accelerated by cellular change, such as the enlargement of nucleus, cellular atypy, and a decreased mucin production. As signet-ring cell carcinoma arise from the neck of glands and infiltrate the propria mucosae under the superficial epithelium, diagnosis by the barium enema and an endoscopic examination is very difficult in the case of small-size lesions. In lesions greater than 1 cm in diameter, these carcinomas usually showed an erosive and/or ulcerated appearance.

Adenocarcinoma, Mucinous↗
PubMed1990

[The relation of stone and carcinoma of the gallbladder based on the mucosal findings].

Based on the mucosal findings in gallbladder patients, intestinal metaplasia was found in 18.4% of such cases without a stone or a carcinoma, in 30% of the with a bilirubin stone, in 37.7% of those with a cholesterin stone, in 69.1% of those with a carcinoma but without a stone and in 78.9% of those with both a carcinoma and a stone. In contrast the incidence of a well differentiated adenocarcinoma was more frequent in the cases with a stone (more often a cholesterin stone than a bilirubin stone) than in cases without a stone. Similarly, the incidence of intestinal metaplasia was more frequent in those with a cholesterin stone than in those with a bilirubin stone. Further, small size lesions were found to be more frequent in the cases of a cancer with a stone. Granular early carcinomas within the superficial muscle layer are usually resected under the diagnosis of gallstone, whereas early carcinoma that protrude are resected as a carcinoma.

Adenocarcinoma↗
PubMed1990

[A resected case of mucin-secreting malignant papillomatosis (villous tumor) of ductus choledocus and left intrahepatic duct].

A resected case of remarkably mucin-secreting malignant papillomatosis (villous tumor) of the ductus choledocus and left intrahepatic duct in a 79 year-old female was reported. In this case, cholecystectomy and choledocho-duodenal anastomosis for the gallbladder stone were performed 14 years ago. Villous or papillary tumors arose in the ductus choledocus and spread into the left intrahepatic duct. Histological examination revealed villous proliferation similar to the villous tumor in the large intestine, in which cancerous and adenomatous changes intermingled showing remarkable mucin secretion. Tumor invasion was limited in the wall without extracanal dissemination, and nodal metastasis was absent. Interestingly, exceeding mucin-secretion was observed as the frog-egg like appearance in the ductus choledocus and as the regurgitation into the stomach by the endoscopic examination. This type carcinomas usually show favorable prognosis compared with the ordinary adenocarcinomas of the bile duct.

Aged↗
PubMed1990

[Clinicopathological study of endometrial-type adenocarcinoma of uterus].

Seventy-one resected cases of endometrial-type adenocarcinoma of uterus were clinicopathologically investigated. As to the gross findings, the incidence of localized type and diffuse type was 47.9% and 52.1%, while that of extroversive type and introversive type was 59.1% and 40.9%, respectively. The incidence of the lesions less than 3 cm in diameter was 36.7% and that beyond 5 cm was 28.1%. The majority (88.7%) of the endometrial-type adenocarcinoma were histologically well-differentiated. Concerning depth of invasion, the incidence of the cases of intramucosal invasion, invasion within 1/3 of muscle layer, invasion between 1/3 and 2/3 of muscle layer, and invasion beyond 2/3 of muscle layer was 19.7%, 46.5%, 16.9%, and 16.9%, respectively. Lymphatic and venous invasion were more frequently found in diffuse, introversive, moderately-differentiated, and deep invasive types than the other types. Lymph nodal metastasis was found in 9.8% of all cases (16.2% in diffuse type, 20.8% in introversive type, 33.3% in moderately-differentiated type and 41.7% in the cases beyond 2/3 of muscle layer).

Adenocarcinoma↗
PubMed1989

Mucosal dysplasia of gallbladder: isolated and adjacent lesions to carcinoma.

Isolated dysplasia was found in 46 (54 lesions) of 2,027 gallbladders, which were histologically studied by serial step sectioning. Average age of patients was 63.8 with a male-to-female ratio of 1 to 3. These lesions, excluding polypoid lesions of adenoma, were located most frequently in the fundus and body, showing flat granular or irregular appearance. As to the size, 68.6% were smaller than 1 cm in diameter (89% were smaller than 2 cm). Most mild dysplasias were found in small lesions less than 0.5 cm in diameter and moderate ones in lesions of less than 1.5 cm, though severe dysplasias were found in various sizes. Gallstones were found in 86.9% of the cases with dysplasia, and intestinal metaplasia and pseudopyloric gland metaplasis were found in 80.4% and 100%. Dysplasia adjacent to carcinoma was found in 46 of 110 cases (41.8%), and this change was frequently found in lesions at the early stage and well-differentiated carcinoma. It seems that mucosal damage caused by a stone and subsequent inflammation may be important in the histogenesis of intestinal metaplasia and dysplasia.

Aged↗
PubMed1989

[Study of early gastric carcinoma from the standpoint of size].

1,112 cases of resected early gastric carcinoma without invasion beneath the propria muscularis were investigated for the location, gross findings and histological findings mainly from a standpoint of size. The incidence of intramucosal carcinomas was 92.7% in the size within 1 cm in diameter, 68.9% in 1 to 2.9 cm, 48.8% in 3 to 4.9 cm and 37.6% beyond 5 cm. Although the incidence of poorly-differentiated adenocarcinomas was 37.9% in the cases within 5 cm, the incidence in the cases beyond 5 cm was 50.8% (most of them consisted of signet-ring cell carcinoma). The larger the tumor size, the more the intestinal metaplastic type carcinomas decreased and the signet-ring cell carcinomas increased. It was suggested that the signet-ring cell carcinoma infiltrates in the propria mucosae for a long time compared with the other type carcinomas.

Adenocarcinoma, Mucinous↗
PubMed1989

[Intestinal metaplasia of the stomach--the significance of single-layer and double-layer metaplasia].

Resected early gastric carcinomas (1,690 cases) and atypical epithelial proliferations (adenomatous lesions, 310 cases) were investigated by the 5 mm-wide step sections. There were two types of intestinal metaplasia; double-layer type, where intestinal metaplasia was in the superficial area with the remaining pyloric or pseudopyloric glands in the deep region of the propria mucosae, and single-layer type, where intestinal metaplasia was usually present in a single layer without remaining deep non-metaplastic glands. These two types of intestinal metaplasia were usually found in the same specimen, however, most of the atypical epithelial proliferations (adenomatous lesions) arose from the area of intestinal metaplasia showing a double-layer type. The mitotic activity was usually found in the transitional zone showing these double-layer intestinal metaplasia. Atypical epithelial cells arose in the transitional zone of the double-layer intestinal metaplasia and spread into the luminal side by budding or replacement of existing epithelial cells. However, the author suspected that the cells in the under area of the transitional zone reproduce non-atypical cells to supplement the cells in the existing pyloric or pseudopyloric glands. On the other hand, atypical epithelial proliferations of single-layer type were rarely found showing a concaved appearance. Some of them may arise from the intestinal metaplasia of single-layer type, where the mitotic region moved towards the lower 1/3 of the glands. It seemed likely that most of the well-differentiated adenocarcinomas arise with intimate relation to these two types of intestinal metaplasia, where the incidence of malignant change of each type has been unknown.

Adenocarcinoma↗
PubMed1989

[Dysplasia of the gallbladder].

Out of 2,027 resected gallbladders that were examined, 46 (2.2%) manifested dysplasia and, to study this further, step sections, 5 mm apart, were performed. The average age of these dysplastic cases was 63.8 years, with a male to female ratio of 1:3. The most frequent dysplastic sites in the gallbladder were in the fundus and the body. Excluding adenomas, polypoid lesions, the dysplasia appeared flat, granular, or irregular. As to diameter, 68.6% were within 1 cm, and 89% were no more than 2 cm. The majority of cases manifesting mild dysplasia had lesions of up to 5 mm in size while the lesions seen in moderate cases were within 2 cm. Stones were found in 80.4% of the cases, and incidences of intestinal metaplasia and pseudopyloric gland metaplasia were found in 80.4% and 100% of these cases, respectively. Incidences of dysplasia adjacent to the carcinoma was seen in 41.8% of the cases, and frequently found in early-stage lesions and well-differentiated carcinomas. Our findings have led us to believe that recognition of the intestinal metaplasia-dysplasia-carcinoma sequence is important.

Adult↗
PubMed1988

Protruded variants in solitary ulcer syndrome of the rectum.

A review of 21 patients with protruded lesions in solitary ulcer syndrome of the rectum confirmed by resection is presented. Symptoms were usually the passage of blood and mucus per rectum, alteration of bowel habit, anorectal pain and rectal prolapse. Solitary or multiple polypoid lesions were found within 15 cm of the anal margin and were usually sited anteriorly. Fifteen of the patients were men and 8 were women with a mean age of 37.1 years. The diagnosis was made on the basis of histopathology; 1) fibrous obliteration of muscle fibers, 2) reactive hyperplasia of the mucous membrane with villous configuration or mild pseudoinvasion. These changes have been observed in complete rectal prolapse, colonic intussusception, and localized colitis cystica profunda, suggesting a common pathogenesis. The histological findings were almost the same as in the ulcerative lesions of this syndrome except for remarkable regenerative hyperplastic changes such as a relatively high incidence of mucous cell proliferation, dilatation of glands and serrate change in the cases showing protrusion. In the pathogenesis, the occult mucosal prolapse in association with excessive straining may be of particular importance, so that the lesions might be termed mucosal prolapse syndrome of the rectum.

Adolescent↗